Diversity at the HYP1 locus in potato cyst nematodes does not result from developmentally-programmed somatic mutations biorxiv.org 2026-07-24 Most genetic diversity stems from spontaneous mutations, that is, errors in DNA repair or replication.
The Tsallis index of the human cortical transcriptome is invariant between bipolar II disorder and control: a pre-registered, cross-platform null with the disease question relocated to correlation structure biorxiv.org 2026-07-24 Gene-expression fluctuations are heavy-tailed and resist description by additive (Boltzmann-Gibbs) statistics, motivating a non-extensive (Tsallis) ac
Stress limits the beneficial effects of glutamine in male ob/ob mice biorxiv.org 2026-07-24 Introduction: Obesity is a major health issue associated with metabolic and psychological comorbidities, as well as an increased prevalence of disorde
Global structure of new relational knowledge networks is represented in retrosplenial complex, and node-distance in hippocampus biorxiv.org 2026-07-25 Much of our knowledge is structured in networks, but how the brain represents such networks remains unclear.
Deep Phenotyping with Global Brain Activity and Plasticity Mapping Identify the Dorsal Raphe-Basolateral Amygdala Circuit as a Mediator of Adaptive Stress Responses biorxiv.org 2026-07-25 Exposure to chronic environmental challenges triggers divergent behavioral trajectories across individuals.
A significant enrichment that is not: spatial nulls, co-expression, and the imaging transcriptomics of EEG alpha-power genetics biorxiv.org 2026-07-25 Background.
Distinct forms of dopamine transmission control locomotion and learning biorxiv.org 2026-07-25 The neuromodulator dopamine is essential for voluntary movement and learning from experience.
Live-imaging of endogenous neurofascins reveals glial adhesion shapes developing nodes of Ranvier biorxiv.org 2026-07-25 The organisation of myelinated axons into specialised domains is essential for saltatory conduction and depends on the polarised distribution of neuro
Developmental tuning of functional manifold dimensionality across the human brain biorxiv.org 2026-07-25 Neural representations vary in their complexity across brain regions and tasks.
AI segmentation requires accounting for brain size to maintain performance on developmental MRI cohorts biorxiv.org 2026-07-25 The human brain undergoes rapid developmental changes through early life, underpinning the emergence of function but also marking a period of vulnerab
Wrong but useful: Bombyx silkworm W chromosome assemblies are flawed but still capture strongly reduced diversity of repetitive DNA biorxiv.org 2026-07-24 Degenerate sex chromosomes (e.g., the Y or W) remain among the most difficult regions of eukaryotic genomes to assemble because they are highly repeti
Comparison of multiple video tracking-based behavioral summary approaches for compound discrimination biorxiv.org 2026-07-24 The rapidly increasing number of video tracking-based behavioral summary tools and methods raises the question as to the most suitable approaches for
Integrated Bioinformatics Analysis Reveals Candidate Hub Genes and Regulatory Networks Associated with Preeclampsia biorxiv.org 2026-07-24 Preeclampsia (PE) is a severe pregnancy-associated hypertensive disorder and a major contributor to maternal and perinatal morbidity and mortality.
CNVeil resolves haplotype-specific copy number and uncovers subclonal architecture hidden from total copy number profiling in single-cell cancergenomes biorxiv.org 2026-07-24 Single-cell DNA sequencing (scDNA-seq) resolves copy number variation (CNV) at single-cell resolution, revealing tumor heterogeneity and subclonal str
Deconvolution-derived cell-type expression targets for personal genome sequence-to-expression prediction biorxiv.org 2026-07-24 Sequence-to-function models learn regulatory features from genomic sequence, but they remain limited in their ability to predict gene-expression diffe
VizR: An Interactive Web Platform for End-to-End RNA-Seq Analysis and Visualization in Plant Biology biorxiv.org 2026-07-24 RNA sequencing (RNA-seq) is widely used to investigate transcriptional programs in plant biology, yet the need to combine multiple specialized tools a
Revisiting Logistic Regression for High-Dimensional Gene Expression Data biorxiv.org 2026-07-24 Logistic regression remains a widely used classification method due to its interpretability and computational efficiency, but its direct application t
Recurring daytime and nighttime modes of VOC emissions in a cool-temperate oak forest biorxiv.org 2026-07-24 Plants emit substantial amounts of biogenic volatile organic compounds (VOCs) that link plant physiological activity to ecological interactions and at
Age-Related Changes in the Neural Dynamics of Speech Production Following Noninvasive Brain Stimulation biorxiv.org 2026-07-24 Non-nvasive brain stimulation is a promising technique to restore neural function in older adults by enhancing cortical excitability.
Recurrent inhibition, not presynaptic inhibition, contributes to the velocity-dependent control of motoneuron output during eccentric contractions biorxiv.org 2026-07-24 It is well documented that both motoneuron output and the effectiveness of activated Ia afferents to discharge soleus -motoneurons decrease during ecc
Multi-area single-cell calcium imaging dataset of the mouse cortex across wakefulness, sleep, and anesthesia biorxiv.org 2026-07-24 We present a reusable dataset of neuronal population activity from multiple cortical areas, recorded from layers 2/3 of the mouse cortex at single-cel
Human cornea harbors tissue-resident memory T cells shaped by systemic immune activation, age and biological sex biorxiv.org 2026-07-24 The cornea is classically regarded as an immune-privileged tissue.
Whole mitochondrial genome sequencing identifies unique haplotype diversity and a lack of fine-scale genetic structure: a case study in the vulnerable estuarine turtle Malaclemys terrapin biorxiv.org 2026-07-24 A central goal when assessing patterns of population structure for conservation is to identify populations with unique genetic compositions.
On the characterization and interpretation of phenotypic ellipse geometry, with examples from Canis and sigmodontine rodents. biorxiv.org 2026-07-24 Data on the shape of a group of organisms can be conceptualized as forming a point cloud in the multivariate space of measurement.
Plasticity of the mutation rate and spectrum in eukaryotic marine phytoplankton biorxiv.org 2026-07-24 The ability to adapt shapes the future of any species or population.
BioGeoSyn: a graphical software for reproducible biogeographic analyses and cross-clade synthesis of biogeographic events biorxiv.org 2026-07-24 1.
Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models biorxiv.org 2026-07-24 Accurate predictions of transcriptomic responses to genetic perturbations could unlock our understanding of gene functions and regulatory networks.
Intergenerational epigenetic signatures of prenatal adversity and their role in emerging child psychopathology biorxiv.org 2026-07-24 Background: Adversity during pregnancy is associated with alterations in offspring brain development.
MetaClaw: an auditable AI agent for end-to-end, multi-directional metagenomic and multi-omics analysis biorxiv.org 2026-07-24 Omics studies increasingly depend on long, multi-directional workflows, making auditability as important as individual analytical tools.
Phenotype-driven de novo molecular design from gene expression signatures biorxiv.org 2026-07-24 Target-based and structure-guided drug design remain central to modern drug discovery, but complementary strategies are needed when predefined targets