Microtubule architecture and detyrosination bidirectionally modulate sarcomere shortening in skeletal muscle fibers biorxiv.org 2026-07-23 Although microtubules (MT) are established regulators of striated muscle mechanics, how MT lattice organization and post-translational modifications (
Leveraging Supramolecular Polymers to Induce the Targeted Protein Degradation of α-Synuclein biorxiv.org 2026-07-23 Halting the progression of neurodegenerative diseases remains one of the foremost challenges in medicinal chemistry due to the complex biology that dr
Programmed chromosome elimination correlates with the overexpression of cohesin and additional B chromosome-encoded genes in Aegilops speltoides biorxiv.org 2026-07-23 Programmed chromosome elimination is a highly controlled developmental process in which specific chromosomes are selectively lost from defined cell ty
A highly penetrant LMNA R541C variant associated with dilated cardiomyopathy leads to dysregulation in metabolism and proliferation pathways in stem cell-derived cardiomyocytes biorxiv.org 2026-07-23 Background LMNA codes a widely expressed nuclear cytoskeletal protein (lamin A/C) with multiple important functions.
PhytoFam: A Nextflow Pipeline for Genome-Wide Analysis of Plant Gene Families biorxiv.org 2026-07-23 Genome-wide identification of plant gene families is essential for functional and evolutionary studies but often requires the use of multiple independ
Nanopore Electrometry Resolves Peptide Charge Patterns beyond Ionic-Current Blockade biorxiv.org 2026-07-23 Localized measurements of electric fields offer a promising route to expand the information content of nanopore-based single-molecule sensing beyond c
Symmetry-breaking flow bifurcation as an under-recognised haemodynamic factor in valve-associated thrombosis biorxiv.org 2026-07-23 Venous thrombosis commonly develops in the vicinity of venous valve pockets, where disturbed haemodynamics, xreduced washout, and endothelial dysfunct
Endometrial transcriptomic and ciliation analysis after scratch shows no signature linked to live birth following IVF biorxiv.org 2026-07-23 Objective: To determine whether endometrial scratch induces differences in transcriptomic profiles or epithelial cell ciliation in the endometrium at
Movement Directions Aligned in Joint Space Are Not Aligned in Muscle Space biorxiv.org 2026-07-23 Learned movements are thought to be represented in both extrinsic and intrinsic coordinate systems.
Non-invasive tracking of ripple-like activity during human sleep using MEG biorxiv.org 2026-07-23 Hippocampal ripples are considered a key mechanism of sleep-dependent memory consolidation.
Sex-biased transcriptional rewiring of neuronal circuits associated with eprinomectin resistance in Haemonchus contortus biorxiv.org 2026-07-23 Anthelmintic resistance poses a critical threat to livestock health, with clinical failures of eprinomectin and other macrocyclic lactones documented
Mediterranean dispersal imposed bottlenecks in Neolithic sheep and goats biorxiv.org 2026-07-23 The Neolithic period in western Eurasia involved major dispersal events, including the translocation of livestock into Europe.
Antibody evasion and receptor binding of SARS-CoV-2 variants PQ.16.1.1 and RK.1 biorxiv.org 2026-07-23 The recent global expansion of the SARS-CoV-2 variant NB.1.8.1 has driven the emergence of sublineages PQ.16.1.1 and RK.1, which independently acquire
PINK1 stabilizes RMDN3-VAPB interaction without altering the landscape of mito-ER contact sites biorxiv.org 2026-07-23 Mitochondria-ER contact sites (MERCS) have emerged as central hubs of organellar biology, participating in the exchange of lipids, Ca2+ and even prote
PROPEL: a high-throughput shear-stress platform reveals organotypic thresholds in endothelial mechano-adaptation biorxiv.org 2026-07-23 Endothelial cells exhibit organotypic specialization, yet the tools to decode whether hemodynamic shear shapes this diversity across vascular beds hav
Proprotein convertase activity regulates cumulus-oocyte-complex matrix integrity and cumulus cell migration during ovulation via a GDF9-dependent mechanism biorxiv.org 2026-07-23 Cumulus cells have well-established roles early in ovulation but the key molecules that drive their behavior in later stages, leading to follicle rupt
A gene-agnostic FACS technique to isolate stem cells in Hydractinia symbiolongicarpus validated with cytology biorxiv.org 2026-07-23 Hydractinia symbiolongicarpus is a powerful model for stem cell research and maintains a population of pluripotent adult stem cells throughout its lif
Cyclin B3-CDK1 couples translational de-repression to embryonic mitoses via OMA protein degradation in C. elegans. biorxiv.org 2026-07-23 During early embryogenesis, gene expression relies on maternally loaded mRNAs whose translation is controlled by RNA binding proteins.
Molecular Mechanism of Lipid Recognition and Membrane-Guided Gating in Plant Minimal START Proteins biorxiv.org 2026-07-23 The hydrophobic nature of lipids requires specialized transport mechanisms, and one such non-vesicular transport mechanism involves START (StAR-relate
Programming protein shape as an explicit design layer via CAD blueprint-guided diffusion biorxiv.org 2026-07-23 In engineering, industrial design principles link geometric form with function.
Towards interoperable modeling of toehold-mediated strand exchange circuits across DNA nanotechnology and engineering biology biorxiv.org 2026-07-23 Originally developed for DNA nanotechnology, toehold-mediated strand exchange (TMSE) circuits are gaining traction in synthetic biology due to their h
GLP-1 and GIP receptor agonism does not directly drive skeletal muscle atrophy or impair myogenesis in primary human myotubes biorxiv.org 2026-07-23 GLP1 and GIP/GLP1 receptor agonists produce substantial weight loss in clinical trials but significant loss of lean body mass is reported.
Mesohabenular glutamatergic regulation of the consequences of uncontrollable stress biorxiv.org 2026-07-23 Perceived or volitional control over a stressor is a critical determinant of resilient versus susceptible behavioral phenotypes.
DROSOPHILA PRICKLE MUTANTS DISPLAY COMORBID NEUROLOGICAL PHENOTYPES AND PROVIDE A GENETIC LINK BETWEEN EPILEPSY AND AUTISM SPECTRUM DISORDER biorxiv.org 2026-07-23 Epilepsy affects approximately 30% of individuals with autism spectrum disorder (ASD).
Phylogenomics resolves a 200-year-old puzzle: a revised tribal classification of Afro-Eurasian dung beetles (Coleoptera: Scarabaeinae) biorxiv.org 2026-07-23 Background.
Non-Canonical Activation of HSF1 Stimulates mTORC1-Mediated Translation in HCMV-Infected Monocytes biorxiv.org 2026-07-23 Human cytomegalovirus (HCMV) is a major cause of organ disease among immunonaive and immunocompromised individuals.
Single-cell analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated murine skin demonstrates that sebaceous gland differentiation precedes Ahr-dependent seboatrophy with elevated expression of infundibular Blimp1 biorxiv.org 2026-07-23 In humans, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces chloracne, a skin condition that presents with acanthosis, hyperkeratosis, comedones, an
Circulating APOH promotes aortic dissection by activating the vascular smooth muscle cell NR5A1-PPARγ pathway. biorxiv.org 2026-07-23 Introductions: Aortic dissection (AD) is a life-threatening vascular disease with limited therapeutic targets.
An openly licensed benchmark and per-gene calibration map for missense pathogenicity predictors on activating cancer drivers biorxiv.org 2026-07-23 Missense pathogenicity predictors such as AlphaMissense are increasingly used in clinical variant interpretation, yet they are trained on germline lab
pHaseMD4AI: Phase-Space Dynamics Dataset with Chemical and pH Perturbations for Physically and Kinetically Consistent Biomolecular AI biorxiv.org 2026-07-23 Protein function emerges from dynamic conformational ensembles and transitions that are challenging to characterize experimentally and computationally