SARS-CoV-2 nucleocapsid protein engages with viral RNA and ERGIC lipids to drive viral core assembly biorxiv.org 2026-07-23 Severe acute respiratory syndrome coronavirus 2 assembles at the ER Golgi intermediate compartment (ERGIC), yet the molecular basis of nucleocapsid (N
Microbial odours activate protective immune response in Caenorhabditis elegans via specific olfactory neurons biorxiv.org 2026-07-23 Caenorhabditis elegans, like other animals, relies on attractive odours for foraging and on aversive odours for avoidance of pathogens.
Plasmodium blood-stage induces trained immunity in hepatocytes biorxiv.org 2026-07-23 Plasmodium parasites, the causative agents of malaria, are transmitted at high levels in endemic areas and sequential infections are common.
RBM6-mediated alternative splicing facilitates the adaptation of Eurasian avian-like H1N1 swine influenza virus biorxiv.org 2026-07-23 The Eurasian avian-like (EA) H1N1 swine influenza virus (SIV), derived from avian influenza viruses (AIV), poses a serious threat to public health due
A genetic screen unveils the polymerization cycle of the bacterial actin-like MreB biorxiv.org 2026-07-23 MreB, a bacterial actin homologue that organizes cell wall synthesis in most rod-shaped bacteria, assembles into membrane-associated filaments through
Genetic Diversity and Antifungal Susceptibility among Ecological Niche Populations of Aspergillus flavus in Yaounde, Cameroon biorxiv.org 2026-07-23 Aspergillus flavus is a ubiquitous fungus commonly found in a variety of ecological niches including soil, crops, the air, and humans.
Human rhinovirus 16 impairs macrophage cytokine secretion by disrupting NF-κB nuclear translocation and intracellular cytokine trafficking biorxiv.org 2026-07-23 Human rhinovirus (HRV) infections are a major cause of acute exacerbations in chronic obstructive pulmonary disease (COPD), often promoting secondary
Single anticodon-edited tRNA therapy targeting highly prevalent Arg>Ter premature termination codons causing inherited retinal diseases biorxiv.org 2026-07-23 Nonsense variants cause 18% of inherited retinal diseases (IRDs), yet current therapies require variant-specific development, leaving most patients un
Widely used GWAS methods can be poorly suited to SNP-level localization under diffuse polygenic architecture in livestock biorxiv.org 2026-07-23 In livestock populations, genome-wide association studies (GWAS) can produce strong, apparently localized associations even when no truly discrete nea
Integrating epigenomic features reveals principles of chromatin-state organization biorxiv.org 2026-07-23 The coordinated activities of histone modifications and chromatin-associated proteins establish chromatin states that regulate genome function and cel
Perturb-seq resolves physiologic programs and bidirectional regulation of non-canonical NF-κB signaling in epidermal organoids biorxiv.org 2026-07-23 Regulated keratinocyte differentiation is required for formation of the stratified epidermis and a functional barrier.
A germline shortcut in protein language model retrieval of adaptive immune receptors biorxiv.org 2026-07-23 Protein language models (PLMs) are increasingly used to represent adaptive immune receptors; however, their advantages over classical alignment-based
Conformational dynamics of exopolysaccharides underlie biofilm matrix mechanics in Vibrio cholerae biorxiv.org 2026-07-23 Polysaccharides remain the least understood biomacromolecules, particularly in terms of the relationship between their chemical structure and physical
Noncanonical Circular RNAs and Potential Functions biorxiv.org 2026-07-23 Circular RNAs (circRNAs) are ubiquitous in eukaryotes; dysregulated circRNA expression is linked to diseases, including lung cancer.
An improved Stentor coeruleus genome and time-resolved transcriptomics link cyclic nucleotide-dependent kinase signaling to single-cell habituation biorxiv.org 2026-07-23 The giant ciliate Stentor coeruleus is a single cell capable of modifying its behavior through experience.
Miniaturized Lysosome Enrichment through Selective Plasma Membrane Destabilization biorxiv.org 2026-07-23 Organelle enrichment presents a prerequisite for the unbiased biochemical analysis of cellular subcellular compartments.
The Holliday junction resolvase GEN1 preserves genome integrity and self-renewal in mouse embryonic stem cells biorxiv.org 2026-07-23 The maintenance of pluripotent stem cells (PSCs) under rapid proliferation requires mechanisms that both suppress replication-driven genome instabilit
A fast 2C-induction method reveals a barrier role of SP2 for totipotency biorxiv.org 2026-07-23 The acquisition of totipotency in vitro remains a major challenge, limiting our understanding of early embryogenesis and its clinical and translationa
A tight balance of anabolic mTORC1 signaling and catabolic autophagic activity regulates zebrafish heart regeneration biorxiv.org 2026-07-23 Zebrafish can regenerate the heart by proliferation of cardiomyocytes.
Collateral effects of lethal management operations: biologging reveals multiscale responses in non-target vervet monkeys biorxiv.org 2026-07-23 Lethal wildlife management operations are typically evaluated through their direct effects on target species, yet their disturbance footprint may exte
Ultrastructure of stemness and differentiated state in Hydra epithelial cells biorxiv.org 2026-07-23 Epithelial cells in Hydra perform an unusual combination of functions: they divide continuously like adult stem cells while simultaneously executing t
From prehistory to present-day: How isolation shaped the distinct genomic makeup of Italian Alpine valleys biorxiv.org 2026-07-23 Historically, the eastern Italian Alps have provided crucial geographic corridors for cultural and genetic exchange between the Mediterranean region a
Fixation Probabilities of Mutant Alleles in an Ecological Context biorxiv.org 2026-07-23 For decades, population geneticists have relied upon a formula derived by Malecot and by Kimura to estimate the fixation probability of mutant alleles
Mobility shapes plasmid GC content evolution biorxiv.org 2026-07-23 Plasmids are frequently AT-rich relative to their bacterial hosts.
Open or closed? Exploring the conformational heterogeneity of human plasminogen across multiple resolution scales biorxiv.org 2026-07-23 Plasminogen (Plg), the zymogen of the fibrinolytic protease plasmin, is a multidomain, conformationally-rich protein that plays a crucial role in targ
Integrated Bioinformatics Analysis of PALB2 Reveals Expression Patterns, Molecular Interactions, and Prognostic Significance in Breast Cancer biorxiv.org 2026-07-23 Background: Partner and Localizer of BRCA2 (PALB2) is a key tumor suppressor gene involved in homologous recombination mediated DNA repair through its
A transparent multicriteria and fuzzy classification approach for genome-based probiotic candidate prioritisation biorxiv.org 2026-07-23 The identification of novel probiotic candidates with potential health-promoting properties remains a major challenge in food biotechnology and increa
MYC/MIZ1 suppression of lysosomal protein degradation drives immune evasion in pancreatic ductal adenocarcinoma biorxiv.org 2026-07-23 The MYC oncoprotein promotes immune evasion of pancreatic ductal adenocarcinoma (PDAC), but the underlying molecular mechanisms are not fully understo
Pulsed priming with the FAK inhibitor narmafotinib enhances both gemcitabine/Abraxane and FOLFIRINOX chemotherapy response in pancreatic cancer biorxiv.org 2026-07-23 Background: Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal malignancy with few treatment options available.
Coupling Mechanical and Metabolic Behavior in Huxley-type Muscle Models biorxiv.org 2026-07-23 Accurate prediction of both mechanical and metabolic behavior of muscle remains an important challenge in biomechanics.