A Circulating TLR2pos CD14neg CD16neg '' Unclassified Subset '' is Decreased in Multiple Myeloma Patients and May Comprise CD163pos Dendritic Cells. biorxiv.org 2026-07-25 Background: Strategies to define human monocytes by flow cytometry vary considerably across studies.
Intracellular pathogen targeting by IL32 elicits cell-autonomous immunity biorxiv.org 2026-07-25 Interferon gamma safeguards humans against intracellular pathogens, yet how most interferon-stimulated genes protect host cells, and how human-adapted
Cryo-electron microscopy structure of Jabs, a bacteriophage infecting the multidrug-resistant pathogen Mycobacterium abscessus biorxiv.org 2026-07-25 Exploring bacteriophage structural diversity is essential for understanding phage biology and for advancing phage-based therapies.
Prevalent phenotypic mutation impairs binding of broadly neutralizing antibodies to influenza hemagglutinin biorxiv.org 2026-07-25 Mistakes during protein synthesis, such as transcription errors, occur often and lead to non-inheritable amino acid replacements generally known as ph
Structural and Stereochemical Elucidation of Cyanochelin C, a Siderophore Associated with Novel Class of Cyanobacterial Acyl Hydrolases biorxiv.org 2026-07-25 Iron is a key micronutrient that constrains microbial growth and productivity in many aquatic and terrestrial environments due to its limited bioavail
Intrafilament nucleotide exchange in a prokaryotic actin homolog biorxiv.org 2026-07-25 Polymerisation and disassembly govern the cellular functions of cytoskeletal proteins.
Outbreak of Dermatophilus congolensis skin infection among contact sport practitioners, Norway, summer 2025 biorxiv.org 2026-07-25 Dermatophilus congolensis is a zoonotic gram-positive bacterium causing dermatophilosis, a skin infection primarily affecting animals and uncommonly r
Characterization of NPR-14 in the Regulation of Sleep-Like Behaviour in Caenorhabditis elegans biorxiv.org 2026-07-25 Sleep-like quiescence is an evolutionarily conserved state essential for physiological homeostasis; however, its dysregulation can lead to sleep disor
Optimized cryo-FIB milling strategy to generate thin, minimally damaged biological lamellae biorxiv.org 2026-07-25 Focused ion beam (FIB)-milling has been adapted to thin frozen cells for visualization of macromolecular structures in situ with cryogenic electron mi
Bidirectional Electron Transfer in Far-Red-Light Adapted Photosystem I. Implications for the Photosystem's Functionality biorxiv.org 2026-07-25 Far-Red (FR) Light Photoacclimation (FaRLiP) enables cyanobacteria to extend photosynthetic activity into the far-red region by extensively remodellin
Genetic architecture of soluble arabinoxylan fibre in elite genotypes of bread wheat revealed by genome-wide association analysis biorxiv.org 2026-07-24 Dietary fibre intake remains below recommended levels, and increasing fibre content of widely consumed white wheat flour (derived from the starchy end
Olfactory Search Behavior Across Flow Regimes Supports a Unifying Framework biorxiv.org 2026-07-24 How animals perform odor-guided search across the broad range of dynamic flow conditions they encounter in nature is not well understood.
The Barcode Inference Pipeline (BIP): From Sequencer Output to DNA Barcodes biorxiv.org 2026-07-24 DNA barcoding involves the recovery of a DNA sequence for a target gene region from its source specimen.
GatorPrism: Prototype-Conditioned Routing across Coalition Graph Experts for Spatial Multi-Omics Integration biorxiv.org 2026-07-24 Spatial multi-omics integration requires balancing cross-omics consensus with modality-specific signals whose importance varies across tissue location
EXCAVATE-HT: A Bioinformatic Pipeline to Identify Targetable Genomic Variants for Allele-Specific Editing biorxiv.org 2026-07-24 Allele-specific CRISPR/Cas editing is a powerful tool with great potential for treating genetic diseases and for uncovering the effects of allelic div
A new automated pipeline for whole genome shotgun sequencing analysis and hazard characterization of microbial pesticides biorxiv.org 2026-07-24 Microbial pesticides are increasingly important for sustainable crop protection, yet hazard analysis and risk assessment remain challenging and requir
Ovarian cancer-on-chip for patient-specific profiling of treatment responses to sequential chemotherapy and PD-L1 blockade biorxiv.org 2026-07-24 Ovarian cancer (OvCa) ranks as the most lethal gynecological malignancy in women worldwide.
Survivorship Bias Explains Age-Dependent Extinction in Fossil Genera biorxiv.org 2026-07-24 Fossil genera exhibit pronounced age-dependent extinction: older genera are more likely to survive extinction events than younger ones.
Imaging-Based Age- and Sex-specific Cardiovascular and Skeletal Phenotypes in Fbn1C1041G/+ Mice biorxiv.org 2026-07-24 Marfan syndrome is a multisystem connective tissue disorder with age-dependent and sex-dependent phenotypic variability.
Hyaluronan and CD44 targeting reverses early matrix changes, proinflammatory signals and fibrosis in primary sclerosing cholangitis biorxiv.org 2026-07-24 Primary sclerosing cholangitis (PSC) is a rare, progressive liver disease characterized by biliary inflammation and bile duct strictures and no approv
Simulating neural network criticality and resource dynamics with Rydberg gases biorxiv.org 2026-07-24 Efficient operation of neural networks has been linked to criticality in their underlying non-equilibrium excitation dynamics.
The Critical Role of Pdyn-Lineage Enteric Neurons in Colonic Motility and Visceral Interoception biorxiv.org 2026-07-24 Sensory neurons play well defined roles in the regulation of intestinal motility, digestion, and interoception, but transcriptional dissection of intr
Gastric-brain coupling dynamics in response to a cognitive challenge reveal distinct autonomic and psychological correlates in healthy individuals and patients with irritable bowel syndrome biorxiv.org 2026-07-24 The gastric's intrinsic slow-wave rhythm couples to ongoing cortical activity in humans, but the functional significance of this gastric-brain couplin
A chicken interferon stimulated gene screen reveals limited genes restricting influenza replication biorxiv.org 2026-07-24 Avian influenza A virus (IAV) is a major global health threat.
Host-like Temperature Unlocks Glucose Uptake and Metabolism in Pathogenic Leptospira biorxiv.org 2026-07-24 Pathogenic Leptospira transitions between environmental reservoirs and mammalian hosts, expose the bacterium to distinct temperature conditions.
Efficient CRISPR/Cas9-mediated homology independent sequence replacement in vivo and non-dividing primary cells biorxiv.org 2026-07-24 Precise sequence replacement in non-dividing cells remains a major challenge for genome editing.
An open-source application for applying rapid transient perturbations using a split-belt treadmill biorxiv.org 2026-07-24 Background: The use of specialized perturbation systems has become an increasingly popular approach for investigating walking stability.
AINN-Express: A Leakage-Aware, Sequence-Only Predictor of VHH Antibody Expression Built on the AINN-P1 Protein Foundation Model biorxiv.org 2026-07-24 Expression -- whether an antibody can be produced at usable yield -- is one of the earliest and most expensive filters in therapeutic discovery.
MeioBIOME: A snakemake workflow for the parallel analysis of meiofaunal genomes and host-associated bacteria/archaea biorxiv.org 2026-07-24 Microbes closely interact with every living organism, including meiofauna (i.e., microbial eukaryotes 38 m - 1 mm in length), and influence the develo
Ultrastructural remodelling of tau fibrils during ghost tangle formation in Alzheimer's disease brain biorxiv.org 2026-07-24 Tau aggregation into intracellular neurofibrillary tangles (NFTs) is one of the major hallmarks of Alzheimer's disease (AD).