Robust Regularization Enables Automated, Real-Time Square-Wave Voltammetry Signal Quantification biorxiv.org 2026-07-27 Square-wave voltammetry (SWV) is widely used for electrochemical biosensing because it enables sensitive, temporally resolved measurement of redox rep
Targeted measurement of blood flow in the Anterior Cerebral Artery using Diffuse Correlation Spectroscopy biorxiv.org 2026-07-27 Significance : Diffuse Correlation Spectroscopy (DCS) is an established technique for non-invasive monitoring of Cerebral Blood Flow (CBF), but existi
The Mechanical and Biological Evolution of Pressure Ulcer Formation and Healing in Mice biorxiv.org 2026-07-27 Pressure ulcers arise from sustained mechanical loading that impairs perfusion and damages skin tissues, yet the coupled mechanical and biological mec
Detecting the Information Flow in Proteins by Hodge Decomposition biorxiv.org 2026-07-27 Allosteric communication in proteins is commonly quantified as a directed or undirected coupling between residues, but such descriptors mix distinct m
B-SMART-Former: An Explainable Transformer-Based Deep Learning Model for Predicting Drug-Drug Interactions Between Biotech and Small-Molecule Drugs biorxiv.org 2026-07-27 Drug-drug interactions between biotech and small-molecule drugs play a critical role in medication safety and therapeutic efficacy.
Spatial modulation of RAF by RAF/MEK glue enables full-dose combination with pan-RAF inhibitor and potent RAS-mutant tumor-selective MAPK and growth inhibition biorxiv.org 2026-07-27 The clinical benefit of MAPK-targeted therapies depends on greater pathway inhibition in tumors than normal tissues.
Differential modulation of crassulacean acid metabolism according to macronutrient deficiencies in C4 Portulaca oleracea biorxiv.org 2026-07-27 C4 photosynthesis and the crassulacean acid metabolism (CAM) rarely co-evolved in a single lineage, but Portulaca can switch from C4 to CAM under drou
The Sulfated PSY Peptide Negatively Regulates Receptor Kinase Activity to Promote Growth biorxiv.org 2026-07-27 Complex signaling pathways organize cell expansion and proliferation across cells to pattern tissues and organs in plants.
APICE-Py: An Open-Source MNE-Python Pipeline for Scalable EEG Preprocessing biorxiv.org 2026-07-27 Electroencephalography (EEG) is fundamental to cognitive neuroscience as it provides a direct measure of human neural activities with millisecond prec
Nutrient flux governs osteogenic fate commitment through the SLC3A1-cystine Axis biorxiv.org 2026-07-27 Skeletal and mesenchymal cells have limited bone-forming potential due to their rarity, tendency for senescence and/or unstable osteogenic lineage com
Senescent tenocytes drive an age-associated loss of cell-extracellular matrix homeostasis, which can be partially restored using dihydroresveratrol biorxiv.org 2026-07-27 Tendons are commonly injured, not only in athletes, but also during normal everyday activities, particularly in older age.
ZHP-2/HEI10 generates CO precursors and triggers procrossover factor coarsening and CO formation through Polo kinase recruitment biorxiv.org 2026-07-27 During meiosis, programmed DNA double-strand breaks (DSBs) are repaired with the homolog to form crossovers (COs) essential for chromosome segregation
The SoxC transcription factors regulate multiple early retinal lineages and function in parallel with Atoh7 to promote retinal ganglion cell genesis biorxiv.org 2026-07-27 Retinal development is orchestrated by a network of transcription factors that guide multipotent retinal progenitor cells (RPCs) to fate-committed lin
Functional Characterization of Transcriptome-Wide Isoform Switching in Hürthle Cell Carcinoma (HCC) biorxiv.org 2026-07-27 Hurthle cell carcinoma (HCC) is an aggressive form of thyroid cancer.
A Neuroendocrine Circuit That Suppresses Excretion and Pelvic Pain During Activity biorxiv.org 2026-07-27 Mate-seeking during peak sexual receptivity is tightly coupled with exploratory movement, a process made more efficient by transient suppression of ex
Phenylalanine Treatment Suppresses Necrotrophic and Biotrophic Pathogens in Mono- and Dicotyledonous Plants biorxiv.org 2026-07-27 L-phenylalanine (Phe) is converted via the phenylpropanoid pathway into phenolic compounds, and elevated phenolic/flavonoid levels are generally assoc
The micro-plant remains preserved on lithics and in the associated sediment of the Hoabinhian Laang Spean cave site, Battambang province, Cambodia. biorxiv.org 2026-07-27 This study seeks to advance understanding of how ancient Hoabinhian communities engaged with the diversity of their environments, focusing on plant re
TAS2R10 Suppresses ABCG2 Transporter-Associated Chemoresistance and Enhances Cisplatin Sensitivity in Head and Neck Squamous Cell Carcinoma biorxiv.org 2026-07-27 Cisplatin resistance remains a major barrier in head and neck squamous cell carcinoma (HNSCC) treatment.
Matrix Stiffness-driven FAK Splicing Tunes Cell Mechanosensing biorxiv.org 2026-07-27 The extracellular matrix (ECM) stiffness influences many physiological and pathological processes.
Actively cycling cells in uninjured connective tissue are not a prerequisite for appendage regeneration biorxiv.org 2026-07-27 Multiple hypotheses have been formulated to explain differences in tissue repair ability across vertebrates.
Microbiome plasticity, not gut morphology, is linked to amphibian larval performance under elevated temperatures and low food quality biorxiv.org 2026-07-27 In many ecosystems, anthropogenic warming is reshaping thermal regimes, leading to resource quality declines and imposing a dual constraint for ectoth
Temperature variation as a driver of Wolbachia release efficacy: implications for dengue control in warming climates biorxiv.org 2026-07-27 Background Wolbachia-based control methods reduce dengue transmission by suppressing Aedes aegypti populations or blocking viral replication, yet thei
Rubber mapping reveals opportunities and current limitations of deforestation due-diligence biorxiv.org 2026-07-27 Commodity maps and the ability to monitor commodity-driven deforestation are essential for sustainability risk assessment and due diligence.
Genome-wide multi-layered epigenomic profiling across human aging biorxiv.org 2026-07-27 Aging is characterized by highly reproducible alterations across multiple layers of the epigenetic landscape, including DNA methylation, chromatin acc
Conformation of the Catalytic Lysine is a Key Determinant of 2-Deoxyribose-5-phosphate Aldolase (DERA) Stereoselectivity biorxiv.org 2026-07-27 2-Deoxyribose-5-Phosphate Aldolase (DERA) is a key enzyme in the pentose phosphate pathway.
Compact red-shifted near-infrared fluorescent proteins enable deep-tissue SWIR imaging with in vivo optical clearing. biorxiv.org 2026-07-27 Compact near-infrared (NIR) fluorescent proteins (FPs) with red-shifted emission are needed for deep-tissue short-wavelength infrared (SWIR) imaging.
Aptaswitch/aptakiss adenosine sensor design based on the selection of new DNA/DNA kissing complexes biorxiv.org 2026-07-27 Kissing complexes involve interactions between complementary loops of two RNA hairpins.
A generalizable speech neuroprosthesis biorxiv.org 2026-07-27 Intracortical brain-computer interfaces (BCIs) can restore communication to people with vocal tract paralysis by decoding cortical activity during att
Computationally guided design of a metastasis-on-a-chip platform for quantitative evaluation of chemotactic cues in developmental cancers biorxiv.org 2026-07-27 Metastatic dissemination is initiated by tumor cells interpreting spatially organized biochemical and biophysical cues that remain difficult to reprod
An integrated single-cell atlas of human lung across the lifespan biorxiv.org 2026-07-27 The healthy adult lung is largely quiescent but can respond to injury and replace damaged or lost cells.