Phage VP882 possesses quorum-sensing-driven lytic induction and stress-mediated host growth suppression mechanisms biorxiv.org 2026-07-27 Vibriophage VP882 launches its lytic cascade upon detection of a quorum-sensing autoinducer produced by its bacterial host.
Bacterial nanotubes extend from a tubeosome organelle to establish an intercellular bridge biorxiv.org 2026-07-27 Bacterial nanotubes are widespread intercellular membranous bridges mediating molecular exchange among neighboring cells, yet their formation and dyna
Atypical myxomatosis in European rabbits is caused by the recombinant myxoma virus involved in species jumping into hares biorxiv.org 2026-07-27 Myxoma virus (MYXV), a member of the Leporipoxvirus genus (species Leporipoxvirus myxoma; family Poxviridae), causes a highly lethal disease known as
Pseudomonas aeruginosa co-opts host antibiotic metabolism by pyocyanin induction of cytochrome P450 enzymes biorxiv.org 2026-07-27 The human opportunistic pathogen Pseudomonas aeruginosa produces copious quantities of the secondary metabolite pyocyanin (PYO).
Integrative Cross-Cohort Meta-Analysis Reveals a Conserved Dysbiotic Signature of Streptococcaceae and Lachnospiraceae in Multiple Sclerosis biorxiv.org 2026-07-27 Background: Multiple Sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation and demyelination in central nervous system (CNS).
Single-cell transcriptomics resolves the developmental transitions from schizont to invasive extracellular merozoite to ring-stage Plasmodium falciparum parasites biorxiv.org 2026-07-27 The progression from mature schizonts to newly formed ring-stage parasites represents one of the largest developmental transitions in the Plasmodium f
Manganese Ion Inhibits Influenza A Virus Replication by Targeting the PA Endonuclease biorxiv.org 2026-07-27 Influenza A virus remains a major global health threat, with rapid mutation and emerging drug resistance underscoring the urgent need for novel antivi
An integrated design strategy for developing and validating microalgal formulations in common bean and rainfed rice biorxiv.org 2026-07-27 Microalgae and cyanobacteria have emerged as promising resources for sustainable agriculture; however, integrated methodologies for the rational desig
Structural homology reveals cerato-platanins as conserved antimicrobials repeatedly co-opted for fungal host colonization biorxiv.org 2026-07-27 Fungal cerato-platanins (CPs) are small (~12 kDa) secreted proteins broadly conserved across filamentous fungi and implicated in a striking diversity
Hierarchical control of bacterial growth efficiency by substrate and taxonomy biorxiv.org 2026-07-27 Heterotrophic bacteria utilize organic carbon as a source of energy and material for growth.
From sewage to shoreline: Tracing antibiotic resistance gene trends through tropical island wastewater treatment pathways biorxiv.org 2026-07-27 Wastewater is a key reservoir and transmission route for antibiotic resistance genes (ARGs), enabling their spread from influent to effluent and into
Citrobacter rodentium infection reveals preserved intestinal resilience in aged intestine biorxiv.org 2026-07-27 Ageing is generally associated with increased susceptibility to enteric infection and is widely considered to reflect progressive deterioration of int
Two Novel Rod-Like Circular RNAs from the Oroarctic Tundra Soil Display Candidate Ribozyme-Like Features: An In Silico Characterization biorxiv.org 2026-07-27 The recent discovery of obelisks, novel deltaviruses, and other viroid-like circular RNAs has greatly expanded the known diversity of autonomous RNA e
Conserved and species-specific STIM autoinhibition revealed by AlphaFold3-guided dissection biorxiv.org 2026-07-27 Store-operated Calcium (Ca2+) entry (SOCE), mediated by dynamic STIM-Orai coupling, is crucial for cellular signaling, yet the molecular architecture
GPSNorm: Gaussian Process Spatial Normalization for Spatial Transcriptomics biorxiv.org 2026-07-27 Spatial transcriptomics technologies enable measurement of gene expression while preserving spatial tissue organization, but they remain highly sensit
RIPPLE: replicate-aware detection of cell-type-anchored proximity gradients in spatial transcriptomics biorxiv.org 2026-07-27 Cell-cell signaling shapes tissue structure and function, yet systematically decoding these circuits with spatial transcriptomics remains an open chal
Single-molecule mass measurements uncover shifting RNA interactions during condensate phase transitions biorxiv.org 2026-07-27 RNA interactions are a key contributor to the formation and disassembly of intracellular protein condensates.
Neuropixels 1536 Channel Quad Base probe reveals brain-wide communication underlying flexible sensorimotor sequences biorxiv.org 2026-07-27 The brain orchestrates billions of neurons spanning hundreds of regions to drive behavior.
Structure-function dissection of huntingtin exon 1 identifies a PRD-driven modifier of neuronal toxicity in Huntington's disease biorxiv.org 2026-07-27 The Huntingtin gene (HTT) contains a conserved, yet expandable CAG repeat within exon 1.
First Evidence of Dicistroviruses Infecting Protists biorxiv.org 2026-07-27 Molecular surveys suggest that RNA viruses are abundant and diverse in the ocean, but the hosts for most of these viruses are unknown because so few h
Genome-wide screen for genes required for smooth lipopolysaccharide production in Escherichia coli K-12 biorxiv.org 2026-07-27 Lipopolysaccharide (LPS) is a major component of the outer membrane of Gram-negative bacteria, contributing to membrane integrity and environmental in
Metabolic cost as a determinant of light quality acclimation: a full-PAR characterization of the CA3 cyanobacterium Nostoc sp. CCAP 1453/38 biorxiv.org 2026-07-27 Light quality acclimation is one of the key drivers of cyanobacterial physiology, ecology, and productivity.
Cortical organoids from congenital DM1 PSCs reveal MBNL-dependent corticogenesis defects and enable preclinical testing of therapeutic compounds biorxiv.org 2026-07-27 Myotonic dystrophy type 1 (DM1) is caused by an expansion of a CTG repeat in the 3' untranslated region of the DMPK gene, leading to accumulation of t
Desialylated platelets promote hepatocyte proliferation via the ERK1/2 signaling pathway biorxiv.org 2026-07-27 Platelets are increasingly recognized as active regulators of tissue repair and liver regeneration beyond their classical roles in hemostasis and thro
Transcriptomic Illuminations: How light intensity reshapes the Chlamydomonas reinhardtii cell cycle biorxiv.org 2026-07-27 The unicellular algae cell cycle can be divided into several phases, including the commitment point (CP), a point-of-no-return where the cell decides
Achiral Odd Mechanics in Cell Monolayers biorxiv.org 2026-07-27 Cell monolayers are active, orientationally ordered materials whose mechanics can depart from near-equilibrium behavior.
SCAMP - an open-source tool for the quantification of calcification in fish larvae biorxiv.org 2026-07-27 Quantifying skeletal mineralization phenotypes in larval fish is complicated by the natural curvature of the notochord and by sample-to-sample variabi
A minimal model of stable autocatalytic RNA-replication through integration of replication, molecular regulation, and energy conversion biorxiv.org 2026-07-27 Catalysis and allostery are complementary principles of biological function: catalysis accelerates biochemical reactions, whereas allosteric regulatio
Container-less Acoustic Levitation Expands Plasma Extracellular Vesicle Proteome Coverage by Mitigating Size-Dependent Peptide Loss biorxiv.org 2026-07-27 Proteomic profiling of plasma-derived extracellular vesicles (EVs) is limited in part by adsorptive loss of peptides and proteins to container walls d
A membrane-bound aromatic O-prenyltransferase catalyzes the last reaction step in citrus auraptene biosynthesis biorxiv.org 2026-07-27 Plants produce a variety of O-prenylated aromatics that exhibit biological activities beneficial to human health, and the presence of the O-prenyl moi