Slow relaxation oscillations in multi-scale adaptive next generation neural masses biorxiv.org 2026-07-28 We have studied the emergence of slow relaxation oscillations in next generation neural mass models with spike frequency adaptation.
Beyond Temporary Scaffolding: Persistent Hippocampal Engagement and Brain-Wide Network Reorganization in Remote Memory Consolidation biorxiv.org 2026-07-28 The standard model of memory consolidation posits a temporary role for the hippocampus.
A Sample to Results Workflow for Compositional Analysis of Multiplexed Amplicon Sequencing Experiments biorxiv.org 2026-07-28 Microbial communities play key roles in the transformation and cycling of elements ranging from required macronutrients to toxic metalloids.
Splicing Factor SF3B2 Regulates Cardiomyocyte Calcium Handling Through Alternative Splicing of Cardiac Ion Channel Genes biorxiv.org 2026-07-28 Background: Alternative splicing is a critical determinant of protein diversity in the heart, where it drives the postnatal functional maturation of c
KIN-29 SIK regulates stress-induced sleep through mitochondrial redox signaling biorxiv.org 2026-07-29 The C.
Environmentally Relevant Polylactic Acid Microplastics from 3D Printing Induce Germline Apoptosis and Reproductive Decline in Caenorhabditis elegans biorxiv.org 2026-07-28 Bio-based plastics, such as polylactic acid, offer an alternative to petroleum-based plastics and a prospect to address the plastic pollution problem.
Network Pharmacology-Guided Discovery of Fungal Autophagy Modulators for Tauopathies: Structural and Proteomic Evidence biorxiv.org 2026-07-28 Autophagic clearance of hyperphosphorylated tau is impaired in tauopathies, leading to the progressive accumulation of toxic tau species.
Assessment of Hyptis suaveolens Extract-Infused Candle Wax as a Mosquito Biorepellent biorxiv.org 2026-07-28 Neurotoxic chemicals, including pyrethroids, neonicotinoids, and chlorinated hydrocarbons, have been effective for mosquito control; however, their co
The Polyploid History of Cultivated Dahlia biorxiv.org 2026-07-28 The cultivated dahlia has a complex evolutionary history that is likely the driver for its diverse floral forms.
STRIDE: Signal Transfer and Aligned Ion-Peak Discrimination for Peptidoform Evidence for Consistent Quantification of Site-Localized Post-Translational Modifications in Large-Scale DIA-MS biorxiv.org 2026-07-28 Data-independent acquisition (DIA) mass spectrometry has emerged as a powerful method for comprehensive post-translational modification profiling in p
Sex-Specific Modulation of Gene Expression by 17beta-Estradiol in Human Meniscal Cells: Pathways to Targeted Osteoarthritis Therapies biorxiv.org 2026-07-28 Osteoarthritis (OA) disproportionately affects women, and estrogen has been implicated in cartilage and joint homeostasis, yet its effects on meniscal
Adaptive immune responses are not causal to SGN death after kanamycin-induced hair cell loss biorxiv.org 2026-07-28 Aminoglycoside antibiotics such as kanamycin induce sensorineural hearing loss by killing hair cells, resulting in secondary degeneration of spiral ga
Colon-to-hind paw cross-organ sensitization is partially mediated by TrkB.T1-facilitated spinal neuroinflammation to activate lumbar DRG neurons biorxiv.org 2026-07-28 Patients with bowel disease can develop referred somatic pain at a later time with unknown molecular mechanisms.
Sex-specific associations of childhood adversity with frontostriatal network organization and anhedonia in young adulthood biorxiv.org 2026-07-28 Introduction: Anhedonia is a transdiagnostic psychiatric symptom linked to increased functional connectivity between the prefrontal cortex and striatu
A geometric-to-neural cascade for cerebral microbleed detection in susceptibility-weighted MRI biorxiv.org 2026-07-28 Cerebral microbleeds (CMBs) are established imaging biomarkers of cerebral small vessel disease and are a defining feature of cerebral amyloid angiopa
Prioritizing Non-coding Variants in Rice GWAS Loci with a Chromatin-Informed DNA Language Model biorxiv.org 2026-07-28 Numerous genome-wide association studies in rice have identified loci associated with diverse agronomic traits.
Flow alters fibrin molecular and network structure and decreases binding of fibrinolytic enzymes biorxiv.org 2026-07-28 Thrombolysis with tissue Plasminogen Activator (tPA), approved for treating acute ischemic stroke (AIS) within 3-4.5 h of symptom onset, converts Plas
H3K27me3 maintains baseline network excitability after status epilepticus biorxiv.org 2026-07-28 The processes by which epileptic insults precipitate the molecular, cellular, and network alterations in the brain that lead to epilepsy are poorly un
PRIME: A Neurophysiology-Informed Bayesian Optimization Framework for Adaptive TMS Motor Hotspot Mapping, Algorithm Design and Monte Carlo Evaluation biorxiv.org 2026-07-28 Background: Accurate primary motor cortex (M1) hotspot identification is a prerequisite for reliable transcranial magnetic stimulation (TMS) protocols
Evaluation of harmonization methods to mitigate assay and cohort effects in plasma p-tau217 biorxiv.org 2026-07-28 INTRODUCTION: The growing number of assay platforms measuring blood-based biomarkers (BBMs) for Alzheimer's disease (AD) has introduced challenges in
Fishery Cooperatives as Institutional Intermediaries in Fragile Contexts: Assessing Social-Ecological Resilience in South-Central Somalia biorxiv.org 2026-07-28 Small-scale fisheries provide essential coastal livelihoods in developing regions, yet they often confront severe institutional voids within fragile-s
A multi-omics characterization reveals distinct molecular signatures in the human motor cortex and lumbar spinal cord in ALS biorxiv.org 2026-07-28 Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disease characterized by the loss of upper motor neurons in the motor cortex (
How do Cockroach Groups Integrate Multiple Attributes in a Best-of-N Task? biorxiv.org 2026-07-28 Collective decision-making experiments have largely focused on simple scenarios in which groups choose between two options that differ along a single
Leveraging Segmentation Variability to Improve Brain Age Prediction biorxiv.org 2026-07-28 Analytical variability in neuroimaging pipelines contributes to concerns about reproducibility in the field.
Mucus cell and ionocyte precursors migrate between epithelial cells to disperse through the zebrafish epidermis biorxiv.org 2026-07-28 Mucus-secreting cells and ionocytes play critical roles in many organs.
Analog intrinsic recoding measures RNA dynamics without chemical conversion biorxiv.org 2026-07-28 Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression.
Bayesian Network Analysis Identifies PREX1 as a Master Regulator of Cytoskeletal Disruption in Inflammatory Bowel Disease biorxiv.org 2026-07-28 Background: Inflammatory bowel diseases are complex multifactorial and polygenic conditions with incompletely understood etiology.
A Curvature Guided Composite Kernel Framework for Differential Gene Selection in Cancer Transcriptomics biorxiv.org 2026-07-28 Identification of differentially expressed genes is a crucial step for downstream tasks on gene data such as biomarker discovery, drug target identifi
Image-based Disease-wide Association Study via Self-supervised Learning links Abdominal MRI Features to 158 Diseases biorxiv.org 2026-07-28 Medical images contain rich phenotypic information that is often not fully captured by manual clinical assessment.
Medulloblastoma Forms Symbiotic Metabolic Partnerships with Macrophages to Establish Leptomeningeal Metastases biorxiv.org 2026-07-28 Leptomeningeal metastases are the primary source of morbidity and mortality for pediatric medulloblastoma patients.