Targeted quantification assays for DNA repair and handling proteins and interactions in Huntington's disease models biorxiv.org 2026-07-29 Huntington's disease (HD) is a life-altering genetic neurodegenerative disorder, with cognitive, motor, and psycho-social effects that have consequent
Unscheduled DNA synthesis reveals a DNA repair hotspot and biomarker of somatic instability at the expanded-CAG repeat tract in the huntingtin gene biorxiv.org 2026-07-29 Somatic instability (SI) of expanded DNA repeats is a hallmark of repeat expansion disorder (REDs) and drives onset and progression in Huntington's di
A tribal-scale phylogenomic perspective on ancestry and major lineages of the allotetraploid Hawaiian silversword alliance (Madieae, Compositae) biorxiv.org 2026-07-29 Premise of the study: Disentangling ancestry of insular plant lineages is important for resolving their evolutionary histories but often complicated b
Vocal biomarkers of aging and Parkinson's disease in a songbird biorxiv.org 2026-07-29 Purpose: Similar vocal impairments occur in normative aging and Parkinson's disease (PD), making differential diagnosis challenging in early stages.
Uncovering key genes related to potato tuber starch concentration from the tuber bulking, maturation stage to storage biorxiv.org 2026-07-29 Potato is the world's fourth major staple crop, and tuber starch is a critical dietary energy source and a food processing raw material.
Hepatic huntingtin loss drives an acute phase response and liver injury in multiple mouse models biorxiv.org 2026-07-29 Multiple therapeutic strategies are being developed to slow Huntington's disease (HD) progression through targeted reduction of huntingtin (HTT) prote
A Bioactive Phospholipid Promotes Rapid Progenitor Lung Progenitor Activation via AP-1 biorxiv.org 2026-07-29 Upon injury to the distal lung, alveolar type 2 cells (AT2s) must make a discrete switch from surfactant factories to stem cells capable of regenerati
The linker histone H1.4 condenses chromatin in maturing postmitotic neurons biorxiv.org 2026-07-29 H1 histones are abundant nuclear proteins that bind to linker DNA at the entry and exit points of nucleosomes.
Midbody inheritance predicts re-entry into quiescence, but not lineage potential, in mouse hematopoietic stem cells biorxiv.org 2026-07-29 Hematopoietic stem cells (HSCs) give rise to all blood cell lineages and possess self-renewal potential.
Targeted DUX4 base editing improves muscle function in an iPSC-derived model of childhood-onset FSHD biorxiv.org 2026-07-29 Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common dominant muscular dystrophies and remains without an approved disease modifyin
Molecular organization of the eukaryotic secretory pathway biorxiv.org 2026-07-29 The eukaryotic secretory pathway is an essential subcellular network comprised of the endoplasmic reticulum (ER) and Golgi organelles.
Evolving stem cell fate capacities and transcriptional priming in the developing olfactory epithelium biorxiv.org 2026-07-29 The olfactory epithelium of adult mammals contains two populations of stem cells that support its remarkable ability to regenerate neuronal and non-ne
Loss of PRDM16 Drives Nasal Septal Deviation through Dysregulated TGFβ2 Signaling biorxiv.org 2026-07-29 Nasal septal deviation affects approximately 20% of newborns globally and 80% individuals in the United States.
A new player in the biochemistry of Anammox bacteria: a multidomain HAO-like protein biorxiv.org 2026-07-29 Anaerobic ammonium-oxidizing (anammox) bacteria are essential players in the global nitrogen cycle, responsible for converting ammonium and nitrite di
ESCAPE: assigning site-specific activity to covalent ligands in cells by prime editing biorxiv.org 2026-07-29 Chemical proteomics has identified covalent ligands targeting cysteine residues across many hundreds of human proteins.
Distinct spatiotemporal immunometabolic remodeling following acute traumatic brain injury biorxiv.org 2026-07-29 Traumatic brain injury induces profound metabolic reprogramming across neurons, astrocytes, and microglia, yet the spatiotemporal organization of thes
Prebiotic cationic amino acids support formation of an ancient protein fold biorxiv.org 2026-07-29 The evolutionary basis for the selection of the standard proteinogenic amino acids remains elusive, particularly for the long cationic amino acids, ly
Cross-species Study of Canine and Human Peripheral Nerve Sheath Tumors: Clinical and Molecular Perspectives biorxiv.org 2026-07-29 Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas. An obstacle to treating MPNSTs is a lack of effective systemic therapies.
Integrated ex vivo screening and transcriptomic profiling to prioritize drug combinations for rare cancers biorxiv.org 2026-07-29 Discovering effective drug combinations requires testing many dose combinations across a diverse panel of tumor models.
Revealing taxonomic signals in plant volatiles with phytochemistry, machine learning and trait mapping biorxiv.org 2026-07-29 Plant volatiles have long been used as taxonomic characters, especially in chemotaxonomy.
Maternal age at reproduction drives multigenerational variation in life-history traits biorxiv.org 2026-07-29 Offspring phenotypes are often influenced by maternal age at reproduction.
Cap-specific second nucleotide ribose methylase CMTR2 is required for transcriptome transition during mammalian germline development biorxiv.org 2026-07-29 Eukaryotic RNA polymerase II transcripts carry a signature m7G cap (Cap0) structure that is co-transcriptionally added to the 5' end, and is essential
Cloudberry-derived nanovesicles: in vitro functional effects in skin cell models and characterization of molecular cargo biorxiv.org 2026-07-29 Cloudberry (Rubus chamaemorus L.)-derived nanovesicles (NVs) represent a promising but still poorly characterized class of plant-derived vesicles with
Structural Mechanisms of DNAJC13 Dimeric Assembly and InsP6 binding in Recycling Endosome Regulation biorxiv.org 2026-07-29 The balance of plasma membrane protein degradation and recycling during endocytosis is regulated, in part, by the large J-domain-containing protein DN
Demographic turnover undermines herd immunity in sympatric free-roaming dogs and cats: implications for zoonotic disease control in urban sentinel sites biorxiv.org 2026-07-29 Vaccination of free-roaming dogs (Canis lupus familiaris) and cats (Felis catus) remains a major public health challenge.
Integrating animal experience into state-switching habitat selection models biorxiv.org 2026-07-29 Movement models often assume that animal decisions depend on perceived environmental conditions.
Mineral dust stimulates microbial exoenzyme activity and enhances carbon mineralization capabilities in nutrient-poor peat soil biorxiv.org 2026-07-29 Nutrient limitation is an important control on heterotrophic microbial activity that helps to stabilize the massive stocks of organic carbon held in o
Identification of conserved age-associated aggregation-prone proteins for natural molecule targeting during aging in Caenorhabditis elegans biorxiv.org 2026-07-29 Aging is associated with proteome remodelling and progressive accumulation of insoluble proteins.
Molecular principles for graded activation of dopamine D1 receptor biorxiv.org 2026-07-29 G protein-coupled receptors (GPCRs) signal across a continuum of activation states, yet how ligands encode distinct signaling efficacies remains poorl
4D Biomimetic Morphing Hydrogel Scaffold via Biaxial Gradient Programming biorxiv.org 2026-07-29 Four-dimensional (4D) materials incorporating functional gradient designs offer a powerful platform for engineering dynamic structures capable of prog