Direction-Specific Effects of Biphasic Transcranial Magnetic Stimulation on Cortical and Cortico-spinal Excitability biorxiv.org 2026-07-30 Aims & Methods: Transcranial magnetic stimulation (TMS) is a well-established tool for inducing cortical excitation.
Reproducible transversal mouse brain sections using low-cost 3D printable resin matrix biorxiv.org 2026-07-30 Rodent brain matrices that produce coronal or sagittal brain sections for histology confer reproducibility and enable high throughput processing of ti
A horizontally acquired and recurrently expanded glycoside hydrolase subfamily across leafhoppers biorxiv.org 2026-07-30 Horizontal gene transfer from bacteria is a known source of metabolic novelty in insects, yet how these acquisitions diversify and persist over evolut
Deep Brain Stimulation Microelectrodes as a Source of Human Subcortical RNA: Validation of a Low-Input Transcriptomic Protocol biorxiv.org 2026-07-30 Background: Understanding the molecular basis of Parkinson ' s disease (PD) phenotypic heterogeneity maybe improved by in vivo access to deep brain ti
Within-host succession from an OXA-48-like to an NDM-type carbapenemase in clonal ST361 Escherichia coli recovered from sequential urinary and bloodstream infection biorxiv.org 2026-07-30 Carbapenem-resistant Escherichia coli (CREc) recovered sequentially from one patient typically retain the same carbapenemase, with escalating resistan
Expanded unbiased population-genomic summary statistics in pixy biorxiv.org 2026-07-30 Estimates of population-genetic summary statistics are often computed from variant-only VCFs, which commonly omit invariant sites (i.e.
Interpretable spatial ecological dynamics reveal ecological retention escape and amplification in pediatric leukemia biorxiv.org 2026-07-30 Spatial transcriptomics enables tumor ecosystems to be examined within their native tissue architecture, yet many computational approaches remain prim
Modular counterplays shape condensation and signaling of chimeric antigen receptor biorxiv.org 2026-07-30 Chimeric antigen receptor-engineered T (CAR T) cell therapy has achieved remarkable clinical efficacy against hematological malignancies but exhibits
Untargeted metabolic analysis reveals intraspecific and organ-specificchemodiversity in Solanum dulcamara biorxiv.org 2026-07-30 Background and Aims. The genus Solanum including the wild species S.
Grant writing coaching groups: A randomized trial to discern the influences of coaching duration and engagement of scientific mentors on participants proposal submission and success rates biorxiv.org 2026-07-30 Introduction The acquisition of National Institutes of Health (NIH) grants is an increasingly competitive undertaking.
Beyond Generic Signal Peptides: ApexSP Enables Cargo-Specific Secretion Design biorxiv.org 2026-07-30 Recombinant proteins are widely used in biopharmaceuticals, industrial manufacturing, and molecular diagnostics; however, efficient secretion remains
Anticodon nucleotide modifications affect translational tuning by the ribosomal CAR surface biorxiv.org 2026-07-30 Nucleotide modifications of the tRNA anticodon can affect protein translation fidelity and speed.
Higher Impulsivity in the Heterogeneous Structure of Theft Recidivists with and without Kleptomania biorxiv.org 2026-07-30 Impulsivity is associated with various maladaptive behaviors, although its specific role in criminology has remained largely unexplored.
Structure-free, site-resolved contrastive learningextends small-molecule discovery beyond the reachof structure-based modeling biorxiv.org 2026-07-30 Virtual screening asks which molecules, among an enormous space of drug-like chemistry, are worth synthesizing and testing against a protein target.
The tripartite neural plate border is a common trait of vertebrates and tunicates biorxiv.org 2026-07-30 The neural crest and neurogenic placodes, which arise from the neural plate border, give rise to morphological characteristics that distinguish verteb
Single-cell lineage tracing of human neuromesoderm organoids reveals TBX6-mediated posterior mesoderm fate diversification biorxiv.org 2026-07-30 Neuromesodermal progenitors (NMPs) drive vertebrate posterior axis elongation, but the lineage hierarchy of human NMP derivatives remains poorly defin
HiBASIL: Hierarchical Bayesian Source Inference and Localization for Spatial Epidemiology biorxiv.org 2026-07-30 1. Identifying spatial origins of biological invasions, disease outbreaks, or environmental contaminants is critical for timely intervention.
Bridging physiological responses to population outcomes under variable thermal stress biorxiv.org 2026-07-30 Embedding thermal tolerance metrics into population dynamics offers a promising toolkit for understanding the impacts of stressful heat events, but th
Global patterns of helminths associated with gelatinous zooplankton: a missing link in marine parasite transmission biorxiv.org 2026-07-30 Gelatinous zooplankton are abundant predators and prey in marine food webs, yet their role in helminth (parasitic worms) transmission remains poorly r
Early and current environments exert distinct effects on immune function in the Orang Asli biorxiv.org 2026-07-30 Humans evolved in environments characterized by subsistence foraging and hunting, high levels of physical activity, and regular and diverse pathogen e
The Candida Genome Database: New Interface and New Tools biorxiv.org 2026-07-30 The Candida Genome Database (CGD; www.candidagenome.org) is both a model organism database and a fungal pathogen database.
Plug-and-Play 3D localization microscopy biorxiv.org 2026-07-30 Point-spread-function engineering by depth-encoding phase masks enables volumetric super-resolution imaging by 3D single-molecule localization microsc
Characterization of PduU Reveals a Modular Tool for Tuning Microcompartment Permeability biorxiv.org 2026-07-30 Bacterial microcompartments (MCPs) are versatile proteinaceous organelles that compartmentalize metabolic pathways, offering promising scaffolds for s
A pan-cancer single-cell atlas of pericytes biorxiv.org 2026-07-30 Pericytes display marked tissue-specific transcriptional identities, raising the question of whether tumour-associated pericytes converge towards shar
NFYA regulates spermatogenesis through multifaceted chromatin interactions biorxiv.org 2026-07-30 During spermatogenesis, germ cells undergo extensive chromatin remodeling to promote highly diverse and stage-specific transcriptional programs that d
One-step generation of mice by Transposon-Enhanced Multi-Plex Orchestration Editing(TEMPO-Editing) biorxiv.org 2026-07-30 Genome-edited mice are widely used to elucidate molecular mechanisms in vivo and are an indispensable tool, particularly for studies aimed at clarifyi
Seasonal Rebalancing of Assembly Processes and Cross-Domain Network Restructuring in Microbial Communities of a Large Eutrophic Lake biorxiv.org 2026-07-30 Harmful algal bloom (HAB) succession in eutrophic lakes arises from seasonal rebalancing of selection, dispersal, and drift across interacting microbi
Lipoprotein(a) promotes thrombosis through platelet activation and promotion of a lysis-resistant thrombus architecture biorxiv.org 2026-07-30 Elevated levels of lipoprotein(a) (Lp(a)) are an independent risk factor for the development of atherothrombotic diseases.
A PDMS-based microfluidic platform enabling dual biochemical and electric-field stimulation for modeling sensory neuron-intervertebral disc crosstalk biorxiv.org 2026-07-30 Inflammation-driven increases in nociception are prominent in pain pathologies associated with intervertebral disc (IVD) degeneration yet are difficul
Impedance-Derived Heart Rate and Heart Rate Variability from tDCS Output Voltage: Sensorless Physiological Monitoring During Electrical Neuromodulation biorxiv.org 2026-07-30 Background: Transcranial direct current stimulation (tDCS) devices adjust output voltage to maintain the target current despite varying impedance.