A Neurotensin Brake on Exploratory Drive under Persistent Threat biorxiv.org 2026-07-31 Avoidance behavior is an adaptive response that delays exploration to promote survival.
Impaired astrocyte-to-neuron cholesterol trafficking drives synaptic dysfunction in Rett syndrome biorxiv.org 2026-07-31 Rett syndrome (RTT) is a severe X-linked neurodevelopmental disorder caused by loss-of-function mutations in the MECP2 gene and characterized by profo
Distinct spatial associations of adversity with hippocampal macro- and microstructure in early adolescence biorxiv.org 2026-07-31 Youth adversity has been associated with alterations in hippocampal structure; however, it remains unclear whether different forms of adversity relate
Synaptic engram underlies memory biorxiv.org 2026-07-31 Memory encoding cells, or engram cells, are sparsely distributed across the brain.
Ephaptic coupling improves the neural population code biorxiv.org 2026-07-31 Neurons share an extracellular medium, so every spike's current sets up a local field that feeds back onto the membrane potential of nearby cells, an
Loss of neurofibromin alters adult metabolism via effects during a developmental critical period biorxiv.org 2026-07-31 Metabolic alterations commonly accompany neurodevelopmental disorders and may contribute to their pathophysiology.
Memory encoding reprograms neuronal transcriptional responses via durable chromatin remodeling biorxiv.org 2026-07-31 The mammalian brain's long-term memory circuits integrate information from prior and new experiences.
White matter conduction in the human brain is mostly slow, with rare high velocity connections biorxiv.org 2026-07-31 White matter bundles play a crucial role in cognitive functions by rapidly transmitting information between brain regions.
A Bayesian Study to Optimally Unveil LDH Kinetic Mechanisms In Vivo biorxiv.org 2026-07-30 Many life-threatening diseases present characteristic changes in metabolic profiles throughout their progression.
Transcript-Specific Site-Directed RNA Editing Reveals Principles for Splice-aware guide RNA Design biorxiv.org 2026-07-30 Site-directed RNA editing (SDRE) utilizing the adenosine deaminase acting on RNA (ADAR) enzymes is commonly facilitated by guide RNAs (gRNAs) optimize
Structural determination of human nucleosomes reconstituted by the ExACT platform biorxiv.org 2026-07-30 The structure and function of eukaryotic chromatin have been extensively studied using conventional salt dialysis-based nucleosome assembly, which has
Exploring the molecular function of metabolites identified in Elite Controllers and their role in epithelial integrity and immune regulation biorxiv.org 2026-07-30 Despite advances in treatment, HIV-1 infection continues to remain a major global health challenge, prompting ongoing efforts to understand the mechan
Gata.a, Tbx21, and Klf6/7 function cooperatively for zygotic genome activation in ascidian embryos biorxiv.org 2026-07-30 In ascidian embryos, gene expression from the zygotic genome begins between the 8- and 16-cell stages.
Complexity-multistability relationships: How does species diversity shape the number of alternative stable states? biorxiv.org 2026-07-30 Ecologists have long investigated how community complexity affects ecological stability, yet how community complexity influences multistability, defin
From introduction to eradication: reconstructing population size and removal history of an invasive species biorxiv.org 2026-07-30 1. Understanding the processes underlying successful eradication of invasive species is essential for achieving global island conservation goals.
Major microbiota transitions across liver disease progression are mediated by key taxa linking host environments and microbial communities biorxiv.org 2026-07-30 The gut microbiome plays a critical role in chronic liver disease, yet quantitative methods that integrate microbial community structure with clinical
Structural and functional insights into the role of Cysteine-Rich Receptor-Like Kinase 18 (CRK18) in Arabidopsis biorxiv.org 2026-07-30 Plants perceive and integrate diverse environmental signals through receptor kinase (RK) networks at the plasma membrane.
Culture enhanced MSCs to boost haematopoietic engraftment in a model of the post-leukaemic bone marrow niche. biorxiv.org 2026-07-30 Relapse remains a leading cause of treatment failure in acute myeloid leukaemia (AML), making haematopoietic stem cell transplantation (HSCT) the only
Demonstration of an Integrated Process for Manure-Based Nitrogen Recovery Using the Biopolymer Cyanophycin biorxiv.org 2026-07-30 The trend towards concentrated animal feeding operations (CAFOs) has served to concentrate not only livestock animals but the waste they produce to co
Rich structure alphabets enable highest accuracy protein search biorxiv.org 2026-07-30 Protein structure databases have grown from thousands of experimentally determined structures to hundreds of millions of AI-predicted models, creating
Deciphering the Effect of Melittin on Murine Cervical Cancer Cells Based on Transcriptomic Investigation biorxiv.org 2026-07-30 Abstract: Melittin, a highly active natural antimicrobial peptide derived from honeybee venom, holds immense pharmacological potential against solid t
Minimally invasive monitoring of clonal evolution through integrated single cell and ctDNA analysis biorxiv.org 2026-07-30 Abstract Circulating cell-free DNA (cfDNA) offers a minimally invasive lens into temporal tumor evolution.
RNA-directed DNA methylation controls seed development and heat stress memory in barley biorxiv.org 2026-07-30 Plant specific RNA-directed DNA methylation (RdDM) mediates the DNA methylation of specific DNA sequences directed by 24-nucleotide long (nt) small in
Photosynthetic assimilate determines branch size and biomass more than branch number in Arabidopsis biorxiv.org 2026-07-30 Shoot branching is a primary determinant of plant form and crop yield, yet whether auxin or carbon supply is the proximal regulator of branching remai
Plant regulator of flower bud differentiation in in vitro plants of Cymbidium tortisepalum var. longibracteatum with TDZ as the key initiator biorxiv.org 2026-07-30 [Background] Cymbidium tortisepalum var.
Teaching adipose tissue as an organ system: addressing weight bias and enhancing anatomical understanding through AdipoAtlas biorxiv.org 2026-07-30 Adipose tissue (body fat) is increasingly recognized as a dynamic organ system essential to human health, with distinct depots that serve specialized
Exosome-Derived Proteomic Signatures Highlight Pathogenic Mechanisms in Moyamoya Disease biorxiv.org 2026-07-30 Background: The etiology and molecular mechanisms of Moyamoya disease (MMD) remain unclear.
Low effective dimensionality of the human functional connectome does not invalidate lesion network mapping biorxiv.org 2026-07-30 Van den Heuvel et al.
Circadian clock regulates intestinal epithelial cell differentiation via NOTCH/Hes1 oscillations biorxiv.org 2026-07-30 The circadian clock regulates diverse cellular processes, including intestinal epithelial cell (IEC) proliferation.
Nicotinamide N-methyltransferase couples inflammation and epigenetic remodelling to hepatic fibrosis biorxiv.org 2026-07-30 Chronic inflammation is a key driver of progression from benign steatosis to metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosi