Low-self-reactive, circulation-biased blood regulatory T cells sense danger-associated nucleotides to restrain atherosclerosis biorxiv.org 2026-05-11 Peripheral blood (PB) is the predominant source of regulatory T cells (Tregs) for clinical applications, yet PB Tregs have not been systematically com
Cardiac Mitochondrial Dysfunction Following Bleomycin-Induced Acute Lung Injury in Rats biorxiv.org 2026-05-11 Background Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are frequently associated with cardiac complications, including myoc
Talin controls the spatial distribution of vinculin tension in focal adhesions biorxiv.org 2026-05-11 Cells transmit force between the extracellular matrix and the actin cytoskeleton through integrin adhesion complexes centred on talin and vinculin.
Energetic benefits of differential migration strategies shift under climate change for a migratory bird biorxiv.org 2026-05-11 Understanding how migratory birds balance energetic costs of movement with wintering benefits requires quantifying their energy expenditure across the
Hydrological balance of a subalpine forest and the effects of fog presence and forest age biorxiv.org 2026-05-11 Subalpine forests in the Alps are fragile ecosystems that play a crucial role in regional water resources and the local climate.
Cp36 serine recombinase as a new tool for zebrafish transgenesis biorxiv.org 2026-05-11 One feature key to the versatility of zebrafish as an animal model for biomedical research is the breadth of genetic tools available, including for tr
Dimensionally traceable 3D microstructures for multimodal microscope calibration biorxiv.org 2026-05-11 High-resolution microscopy techniques are used across research and industry to analyse biological systems, from biomolecules to subcellular organelles
A mechanistic framework for photon-to-carbon efficiency: coupling photosynthetic energy supply and light respiration in microalgae biorxiv.org 2026-05-11 Photon-to-biomass conversion efficiency in oxygenic phototrophs can vary widely under controlled cultivation, yet its mechanistic origin remains diffi
G-SPRI: A Structure-Centric Graph Model for Comprehensive Prediction of Cancer Driver Events from Missense Mutations biorxiv.org 2026-05-11 In silico approaches for predicting the functional impact of missense mutations are critical for interpreting personal genomes and identifying disease
sxRaep: A Rapid and Accurate Enzyme Predictor for high-throughput mining of enzymatic sequences biorxiv.org 2026-05-11 Metagenomic sequencing generates petabyte-scale sequence datasets that strain both deep learning and alignment based enzyme annotation tools.
A fine-tuned genomic language model adds complementary nucleotide-context information to missense variant interpretation biorxiv.org 2026-05-11 Missense variant interpretation remains a central challenge in clinical genomics.
Predicting Discrete Structural Transformations in Small Molecules from Tandem Mass Spectrometry biorxiv.org 2026-05-11 Tandem mass spectrometry (MS/MS) fragments molecules into smaller pieces, generating spectra composed of m/z values and intensities that encode struct
The astrocyte-enriched gene Tmem44 regulates circadian protein translation in mouse astrocytes biorxiv.org 2026-05-11 Astrocytes contain cell-autonomous circadian clocks, but how astrocyte-enriched clock-controlled genes feed back onto the circadian clock remains poor
Decorrelation by gain control in the mouse olfactory bulb biorxiv.org 2026-05-11 Classifying sensory stimuli requires neural circuits to transform overlapping inputs into representations that are more distinct and decodable.
Facility-Scale Workflows for Data Acquisition, Standardization, Machine Learning Analysis, and Reproducible Science biorxiv.org 2026-05-11 Scientific user facilities routinely generate large-scale microscopy datasets across diverse instruments and vendors, differing substantially in file
Angiotensin II and cAMP signaling pathways regulate mitochondrial biogenesis and activity in human adrenocortical cells. biorxiv.org 2026-05-11 Mitochondrial homeostasis, governed by the balance between biogenesis and mitophagy, is essential for steroidogenesis in adrenocortical cells.
Principles of Local and Global Grouping that Underlie Segmentation of Natural Texture Images biorxiv.org 2026-05-11 The human visual system segments images using both high-level recognition mechanisms and low-level mechanisms that are largely independent of specific
ParSeek: Accurate cryo-EM particle picking with a deep learning model trained on synthetic data biorxiv.org 2026-05-11 Accurate particle picking from noisy cryo-EM micrographs is essential for high-resolution reconstruction.
Microphysiological Flow Batteries For Dynamic EDC Screening Of mESC-derived Thyroid Organoids biorxiv.org 2026-05-11 Endocrine disrupting chemicals (EDCs) are ubiquitous environmental contaminants capable of dysregulating the production of thyroid hormones.
Cosine Similarity Conflates Clinically Distinct Cancer Variants: A Case for Typed-Graph Retrieval in Precision Oncology Decision Support biorxiv.org 2026-05-11 Cancer variant interpretation increasingly relies on retrieval from biomedical knowledge bases, with cosine similarity over neural text embeddings now
Frequency-domain identification of photosynthetic regulation under fluctuating light biorxiv.org 2026-05-11 Plant photosynthesis operates under naturally fluctuating light, yet its dynamic responses across timescales remain incompletely understood.
Susagi: A Microbiome World Model biorxiv.org 2026-05-11 Motivation: Accurately modelling how microbial communities assemble and change across hosts and environments is essential for analysis and interventio
Lense: Optimizing data preprocessing in single-cell omics using LLMs biorxiv.org 2026-05-11 Data preprocessing is critical for single-cell omics analyses, but default pipelines often underperform on diverse datasets, especially from emerging