Self-organizing physical and biochemical interactions explain diverse behaviours in Physarum polycephalum biorxiv.org
Engineering a pacemaker-driven human mini-heart guided by spatial multi-omics of sinoatrial node development biorxiv.org
Dogcatcher2: Improved statistical detection of transcriptional readthrough and repetitive element analysis across sequencing platforms biorxiv.org
Carbohydrate active enzymes in Pectobacteriaceae: coevolving enzyme sets and host adaptation biorxiv.org
Discovery and Characterization of Interleukin-4-Specific Affibodies for Affinity-Controlled Protein Release and Macrophage Polarization biorxiv.org
Sequentially Self-Assembled Supramolecular Nanocomplexes Enable Systemic Cas9 RNP Delivery and In Vivo Tumor Genome Editing biorxiv.org
Molecular Star Gazing: Development and Validation of an Environmental DNA Assay for the Imperiled Sunflower Sea Star (Pycnopodia helianthoides) biorxiv.org
Serum proteomic atlas reveals distinct molecular signatures of lupus nephritis activity, chronicity, and treatment response biorxiv.org
Virtual screening and zebrafish phenotype-based evaluation argues against repurposing 4-phenylbutyrate for STXBP1-relateddisorders biorxiv.org
Systematic toxicological study of PFOS/PFOA co-exposure driving prostate cancer: Core target identification, TME immune remodeling, and combination drug prediction biorxiv.org
CausalKnowledgeTrace: A Novel Computational Framework for Automated Literature-Based Causal Graph Construction and Evidence-Based Variable Selection in Biomedical Research biorxiv.org
BatchVaria: a variance-aware framework for evaluating batch correction in high-dimensional omics data biorxiv.org
A novel vaccine and drug targets for global eradication of bovine tuberculosis: Holistic frameworks for construction of a potent vaccine and identification of drug targets biorxiv.org
TMEM119+ microglia MHC class I restricted antigen presentation impacts CD8 T cell memory, effector status, and blood-brain barrier disruption during neurotropic virus infection biorxiv.org
Spatially resolved transcriptomic and proteomic profiling reveals cell interaction programs that predict Barrett's esophagus progression biorxiv.org
Interlayer Communication Integrates Genetic and Mechanical Signals for Robust Leaf Morphogenesis biorxiv.org
Additive manufacturing of PEDOT:PSS electrodes on collagen substrates for soft and bioactive electronics biorxiv.org
Transcriptomic profiling of embryo-derived cell lines from the Chagas disease insect vector Rhodnius prolixus biorxiv.org
Pericentromeric repeat copy number tunes heterochromatin dosage to control chromosome segregation and gene expression in fission yeast biorxiv.org
Targeting cancer-associated cell surface RNAs with oligonucleotide-drug conjugates enables broad antitumor activity biorxiv.org
Size-dependent nucleus-vacuole interactions in budding yeast demonstrate a role for steric packing in organelle shape and positioning biorxiv.org