Prior experience dynamically determines differential cue weighting in the medial entorhinal cortex biorxiv.org 2026-07-22 Spatial navigation depends on integrating multiple cue sets whose influence is determined primarily by their inferred reliability.
Genotype-by-environment-by-environment (GxExE) interactions have the potential to shape adaptation in response to multiple stressors biorxiv.org 2026-07-22 Rapid adaptation in complex environments depends not only on the amount of genetic variation, but also on patterns of covariation among traits targete
Evolution of regulatory chromatin contacts: insights from duplicated genes biorxiv.org 2026-07-22 In multicellular organisms, gene expression is controlled by numerous cis-regulatory elements that can be located far away from their target genes on
Cerebral Encoding of Word Classes is Distributed and Context-Dependent biorxiv.org 2026-07-23 Word classes such as nouns, verbs, and adjectives are fundamental units of language, but their neural encoding remains unclear.
Embodied reinforcement learning in the primate cortico-basal ganglia system biorxiv.org 2026-07-23 Learning the value of environmental stimuli from reward experience allows animals to make advantageous choices.
Unsupervised nonmotor learning in the human cerebellum biorxiv.org 2026-07-23 A core motor function of the cerebellum is error-based learning: it uses prediction errors--mismatches between predicted and actual sensory feedback--
Lexical and Semantic Coding in the Occipital Cortex of Sighted and Blind biorxiv.org 2026-07-23 How early visual cortex (EVC) supports language and semantic processing in sighted and congenitally blind individuals remains debated.
Area-level context and functional brain organization across the lifespan biorxiv.org 2026-07-23 The neighborhoods children grow up in are associated with cognitive and mental health outcomes across the lifespan.
Sulfur amino acid restriction prevents S-adenosylmethionine-driven liver steatosis, hepatocellular carcinoma, and metabolic remodeling in high-fat-fed GNMT-null mice biorxiv.org 2026-07-22 The expression of glycine N-methyltransferase (GNMT), a critical regulator of S-adenosylmethionine (SAM) levels, is down-regulated in humans with meta
Multidimensional control of ingestive behavior by lateral hypothalamic neurotensin neurons biorxiv.org 2026-07-22 Consumption of food and water is regulated by interactions between neural circuits that govern motivational drive states, arousal, motor activity, and
Non-canonical ribosome organization enables translation stalling in neuronal RNA granules. biorxiv.org 2026-07-22 Neuronal outgrowth to support cognitive functions relies on a timely supply of proteins to distal sites in the neuron.
Accumulation of Lipid Droplets in Microglia following Neonatal Brain Hypoxia-Ischemia biorxiv.org 2026-07-22 Background Hypoxic-ischemic encephalopathy (HIE) is a major cause of neonatal mortality and neurodevelopmental impairments.
Spatially unitized associations occupy an intermediate position along the item-to-association continuum in older adults biorxiv.org 2026-07-22 Older adults show disproportionate impairments in associative memory relative to memory for individual items.
Human antibody heavy chain variable region exon interacts with 3' regulatory region to form a stable somatic hypermutation center biorxiv.org 2026-07-22 Activation-induced cytidine deaminase (AID) initiates somatic hypermutation (SHM) of immunoglobulin heavy chain (HC) variable region exons in germinal
Beyond eplet counts: machine learning integration of evolutionary distance and electrostatic divergence improves prediction of HLA-DQ donor-specific antibody formation after kidney transplantation biorxiv.org 2026-07-22 Background. The emergence of donor-specific antibodies (DSA) against HLA-DQ reduces graft survival and limits future transplant options.
Intravital Cholesterol Depletion Reduces Membrane Dynamics and Increases Mechanosensitivity in Osteocytes In Vivo biorxiv.org 2026-07-22 Osteocytes detect mechanical forces within bone through signaling processes organized at the plasma membrane.
Seasonal variation mediates the importance of species attributes in plant-pollinator interactions biorxiv.org 2026-07-22 Predicting species interactions remains a major challenge, as multiple species attributes operate simultaneously and their relative importance may var
Using Deep Learning to predict replication timing reveals baseline control of genomic DNA sequence biorxiv.org 2026-07-22 Human DNA replicates according to a precise schedule: certain regions are replicated early, while others replicate later in the cell cycle.
Hobrac: a reference-guided workflow for genome comparison and synteny visualization biorxiv.org 2026-07-22 Whole-genome comparison is fundamental for validating genome assemblies and investigating genome evolution, yet identifying suitable reference genomes
scLEMBAS: Context-Aware Modeling of Signaling Pathway Activity at Single-Cell Resolution biorxiv.org 2026-07-22 Cells sense and integrate extracellular cues through intracellular signaling networks that reshape transcription factor activity to dictate cellular r
Learning Minimal Gene Programs for Disease-Aligned Representations biorxiv.org 2026-07-22 Identifying small, interpretable gene sets that robustly capture disease-associated variation in single-cell transcriptomic data remains a central cha
Individual Differences in Color-Induced Visual Discomfort Reveal a Pupillary Dissociation Across Stimulus Dimensions biorxiv.org 2026-07-22 Visual discomfort (VD) is influenced by both spatial structure and chromatic context.
Deep Learning Based Cross-Modality Histological Brain Section Registration in Multiple Species Using Synthetic Images biorxiv.org 2026-07-22 Large-scale brain mapping increasingly relies on integrating histological imaging datasets within standardized anatomical reference frameworks.
A Brain Circuit for Status Epilepticus biorxiv.org 2026-07-22 Status epilepticus (SE) is a life-threatening persistent epileptic seizure that can arise from various brain structures, leaving its brain circuit unk
Does transection severity determine the way of spinal cord repair in the spiny mouse? biorxiv.org 2026-07-22 The mechanisms of the spinal cord regeneration after complete spinal cord transection were investigated in spiny mice.
Engineered Amphiregulin Promotes Tissue Healing via Dual Regenerative and Immunomodulatory Functions in Tissue-Resident Non-Immune Cells biorxiv.org 2026-07-22 Amphiregulin (AREG), a growth factor prominently expressed by immune cells, has emerged as an important mediator of tissue healing.
The "dark magic mushroom" co-produces amatoxins and psilocybin biorxiv.org 2026-07-22 The most famous chemicals produced by mushrooms are the psychedelic compound psilocybin from "magic mushrooms" and amatoxins from deadly poisonous mus
Muon Reduces the Training Cost of Regulatory DNA Transformers biorxiv.org 2026-07-22 Gene-therapy design depends on identifying regulatory sequences that drive the right level, timing, and cell-type specificity of expression.
Integrating single-cell and bulk transcriptomic perturbation resources reveals complementary therapeutic spaces for drug repurposing biorxiv.org 2026-07-22 Transcriptome-based drug repurposing can accelerate therapeutic discovery, but is limited by fragmented resources, inconsistent quality control, and r
Kinetic proofreading decouples signal strength and range in paracrine gradient formation biorxiv.org 2026-07-22 Spatial gradients of signaling molecules pattern multicellular tissues with high precision.