Aberrant neuron-OPC synaptic transmission and deficient myelination define sex bias in major depressive disorder biorxiv.org 2026-06-16 Sex bias is a notable feature of major depressive disorder (MDD), yet its cellular and molecular origins remain unclear.
Maternal immune activation and peripubertal stress differentially disrupt glutamatergic, endocannabinoid, and neuromodulatory signalling in the adult rat dorsal hippocampus: implications for excitatory-inhibitory balance biorxiv.org 2026-06-16 Disruptions in excitatory-inhibitory (E/I) balance during neurodevelopment have been implicated in a range of psychiatric conditions, yet the neuroche
Uncovering genomic regions controlling root quality traits in Cassava (Manihot esculenta Crantz) using different GWAS models biorxiv.org 2026-06-15 Cassava is a major staple crop in tropical regions, and improving its root nutritional quality, particularly carotenoid and dry matter content (DMC),
A pleiotropic EPAS1 enhancer mediating Tibetan adaptation to hypoxia is active in adipocytes biorxiv.org 2026-06-15 In response to hypoxic stress at high altitudes, variation at the EPAS1 locus has experienced strong selection in Tibetans.
Chromosome-level genome assembly of the Northeast China Brown Frog (Rana dybowskii) biorxiv.org 2026-06-15 Rana dybowskii is distributed across Northeast Asian and represents a valuable medical resource.
In situ polymerized monolith tips for reproducible, format-flexible proteomic sample preparation applied to biofluids biorxiv.org 2026-06-15 Sample preparation increasingly sets the throughput and reproducibility of mass spectrometry (MS)-based proteomics.
A low-cost method for collecting and measuring sinking speed of particles in coastal zones biorxiv.org 2026-06-15 Sinking marine particles is a key process regulating carbon export through the biological carbon pump, yet direct measurements of sinking dynamics rem
Effects of Ankle Stiffness on Total Leg Kinematics, Mechanics, and Muscle Activation during Walking biorxiv.org 2026-06-15 Purpose: Ankle stiffness can be altered by normal aging, bone and joint pathology, and treatments such as orthoses or surgical joint fusion.
Multiple Fault Analysis and Drug Therapy on Signaling Pathways Using Dynamic Bayesian Network-based Model biorxiv.org 2026-06-15 Cell growth is an intricate biological phenomenon that is closely regulated by the interplay between various growth factors and transcription factors.
Founder advantages in cell colony geometric organisation biorxiv.org 2026-06-15 Since the earliest microscopic observations, the geometric organisation of cells has captured biologists' interest. Recent work by Gorgi et al.
Xist expression in male Peromyscus leucopus is associated with restricted chromatin repression and incomplete X-to-autosome dosage compensation biorxiv.org 2026-06-15 X-chromosome inactivation (XCI) equalizes X-linked gene dosage between XX females and XY males in eutherian mammals and is canonically initiated by th
Dehydration/1,6-addition-based Site-specific Bioconjugation Unveils Norepinephrinylation as a Widespread Post-translational Modification in the Cellular Proteome biorxiv.org 2026-06-15 Norepinephrine (NE) is a key neurotransmitter and hormone involved in diverse physiological and pathological processes.
An EpCAM-Targeted Mirror-Image DNA Nanostructure for Precise Drug Delivery in Triple-Negative Breast Cancer biorxiv.org 2026-06-15 Triple-negative breast cancer (TNBC) remains a major therapeutic challenge due to the lack of effective molecular targets and the dose-limiting off-ta
Local and non-local impacts of intra-hexamer interactions on temperature compensation of KaiC biorxiv.org 2026-06-15 A hexameric clock protein KaiC exhibits a 24-hour phosphorylation cycle with a unique property termed temperature compensation.
An Unprecedented Cluster in a Methanotroph Acetol Dehydrogenase biorxiv.org 2026-06-15 Biocatalytic metal-containing clusters are nanometer-sized chemical reactors that enable enzymes to perform chemistry far beyond what would be possibl
Weak evidence for change in wind-induced bending moments on raised and thinned Colorado spruce (Picea pungens) biorxiv.org 2026-06-15 Trees are routinely pruned to mitigate the risk of wind damage, but there are few studies examining changes in wind loads after pruning, especially fo
Efficient Transmission in the Blowfly Early Visual Synapses Through the Regularization of Vesicle Release biorxiv.org 2026-06-15 Early studies of synaptic transmission by Bernard Katz and colleagues suggested that neurotransmitter release at graded-potential synapses occurs thro
Mechanical analysis of spatiotemporal traction stress dynamics in a bleb-driven migrating cell, Amoeba proteus biorxiv.org 2026-06-15 Many adherent eukaryotic cells exhibit amoeboid locomotion, where traction stress exerted on the substrate is essential for movement.
A latent 5-dimensional space for action representation: Geometric validity and dissociation from kinematics biorxiv.org 2026-06-15 A fundamental question in visual perception is how the human visual system transforms the rich kinematic information present in observed actions into
SMS: Symmetric Mediation Statistics for Powerful High-Dimensional Mediation Analysis biorxiv.org 2026-06-15 Background: Mediation analysis of high-dimensional features, particularly molecular-level omics features, provides important opportunities to uncover
Albumin integrates liver functional status to initiate regeneration biorxiv.org 2026-06-15 How an organism detects organ injury to initiate regeneration remains one of the central unresolved questions in regenerative biology.
Scaling up polarization-sensitive optical coherence tomography to image the whole macaque brain biorxiv.org 2026-06-15 Polarization-sensitive optical coherence tomography (PS-OCT) is a label-free imaging technique that exploits birefringence to visualize myelinated axo
Scout-based Multi-Echo NAvigator (SMENA) for high temporal resolution motion and B0 estimation and correction: applications to multi-echo GRE and EPTI biorxiv.org 2026-06-15 Purpose: To develop a data-driven technique, Scout-based Multi-Echo NAvigator (SMENA), for joint estimation of motion and B0 inhomogeneity ({delta}B0)
How to Catch a Blank Mind? Brain Similarities and Differences between Self- and Probe-Caught Mind Blanking biorxiv.org 2026-06-15 Mind Blanking (MB) is a mental state characterized by the experience of a seemingly empty mind.
Resolution of MALDI-TOF MS Compared to Whole Genome Sequencing for the Identification of Vibrio parahaemolyticus Strains Isolated from Oysters biorxiv.org 2026-06-15 Climate change and eutrophication are driving the expansion of the range of Vibrio species, including V. parahaemolyticus.
Anthropogenic disturbance inverts microclimate stratification in tropical forests biorxiv.org 2026-06-15 Tropical rainforests generate and maintain their own microclimate regimes and the resultant cooler, more humid and stable environments foster the hype
An ancient receptor family illuminates the evolution of animal sensation biorxiv.org 2026-06-15 Animals use nervous systems to sense and respond to their environment.
Diversity and Spatial Segregation of TRP Channels in Choanoflagellates Provide Insight into the Evolutionary Origin of Animal Sensory Systems biorxiv.org 2026-06-15 Sensory systems, built around specialized cell types, are central to how animals perceive and respond to their environments.
Deep evolutionary origins of the connexin gene family biorxiv.org 2026-06-15 The vertebrate connexin family encodes a diverse repertoire of transmembrane channels that mediate both intercellular communication and cytosol to ext
The old pipe gives the sweetest smoke: A phylogenetic turn for eDNA metabarcoding biorxiv.org 2026-06-15 Environmental DNA (eDNA) metabarcoding has transformed biodiversity monitoring, yet most analyses rely on taxonomic metrics that are sensitive to meth