Contrasting effects of forest fragmentation on the genetics and microbiomes of an endangered arboreal primate biorxiv.org 2026-06-16 Landscape fragmentation, one of the leading drivers of biodiversity loss, can reshape both the genetics and microbiomes of wild populations.
Development of binding and activity inhibition assays for the antibiotic resistance-associated protein PhoQ biorxiv.org 2026-06-16 Antimicrobial resistant infections present a growing threat to public health and were associated with or directly caused 6 million deaths globally in
De novo Design of Polymorph-Specific Binders Targeting α-Synuclein Fibrils biorxiv.org 2026-06-16 Alpha-synuclein (aSyn) aggregation into amyloid fibrils is a hallmark of synucleinopathies, a group of neurodegenerative disorders that includes Parki
Coordination of turn-related activity in the superior colliculus with locomotor dynamics and hippocampal representations of possible futures biorxiv.org 2026-06-16 Turning left or right is a core element of animal navigation.
When to learn from elders or peers: accessibility-knowledge trade-offs explain diversity in age-biased social learning biorxiv.org 2026-06-17 In many animal species, individuals acquire knowledge from others that enhances their survival and reproduction.
A Curated Genome-Scale Nucleotide Diversity Panel of Non-Human Primates biorxiv.org 2026-06-17 Background: Primates constitute one of the most phylogenetically and ecologically diverse Eutherian mammalian orders, with a central role in advancing
The role of long-range transcriptional regulation in interpretation of non-coding variants associated with human disease biorxiv.org 2026-06-17 Genome-wide association studies (GWAS) are the key tools for the discovery of associations between single nucleotide polymorphisms (SNPs) and phenotyp
Socially learned call sequences reveal gradual development of higher-order structure biorxiv.org 2026-06-17 Syntax was long considered to distinguish human language from other vocal systems, with parallels in non-human animals historically limited to song.
Sleep enhances spatial schema memory formation in humans biorxiv.org 2026-06-17 Schema memory, a generalized representation formed across episodes sharing regularities, is thought to arise through sleep-dependent systems consolida
Single-cell chromatin tracing reveals multimodal molecular programs during memory formation biorxiv.org 2026-06-17 Experience-dependent activity is converted to coordinated molecular programs in neuronal ensembles during memory formation.
Directed Human Structural Connectome Reveals Hierarchical Organization and Shapes Large-Scale Brain Dynamics biorxiv.org 2026-06-17 The human structural connectome, most commonly derived from diffusionweighted imaging (DWI) and tractography, provides a macroscopic description of wh
Functional projection of cognitive functions through the human corpus callosum biorxiv.org 2026-06-17 Reconciling the anatomical observation that the human brain comprises two asymmetrical halves with the phenomenal unity of the mind is a puzzle that h
Early sensory deprivation drives local reorganization of sensory integration within a conserved global hierarchy biorxiv.org 2026-06-17 The human brain processes sensory information through a hierarchical system, from primary to higher-level regions, integrating inputs across modalitie
MacaSurfer: unified surface-volume mapping of the macaque brain across the lifespan biorxiv.org 2026-06-17 Macaque brain MRI is central to translational and comparative neuroscience, yet multi-site, longitudinal, and cross-species analyses are hindered by a
Disruption of prefrontal cortex accelerates sensory anchoring but dissociates online recognition from implicit consolidation of sound sequences biorxiv.org 2026-06-16 The auditory brain excels at extracting predictive regularities from sound, but the neural and temporal mechanisms mediating long-term learning of the
Using the Collaborative Cross to Dissect Immunological Mechanisms Governing Latent Infection, Granuloma Formation, and Neuroinvasive Disease Following Repeated Very Low-Dose Inhalation Exposure to Cryptococcus biorxiv.org 2026-06-16 Background.
Biologic therapy is associated with selective changes in airway eosinophil subpopulations in severe asthma biorxiv.org 2026-06-16 Rationale: Eosinophilic airway inflammation is common in severe asthma and strongly associated with symptoms, exacerbations, and impaired lung functio
Ecological networks balance connectivity with flexibility to perturbations biorxiv.org 2026-06-16 The complexity--stability debate in ecology remains unresolved in part because its empirical basis is limited.
Integrated behavioural, morphological, and reproductive responses reveal a trade-off during diapause in Culex pipiens biorxiv.org 2026-06-16 Diapause is a critical adaptive strategy that enables temperate mosquito species to survive adverse environmental conditions and maintain population p
Distinct thermal responses of a host plant and an invertebrate herbivore affect ecosystem productivity and disease dynamics in a coastal marine ecosystem biorxiv.org 2026-06-16 Biological rates, like growth, tend to have unimodal (hump-shaped) responses to temperature, and these relationships can vary among species and biolog
Can digital epidemiology indicate the emergence and current distribution of canine dirofilariosis? biorxiv.org 2026-06-16 The emergence and spread of vector-borne pathogens, such as the mosquito-borne parasite Dirofilaria immitis, the causative agent of canine heartworm d
A Whole-Genome and Ancient DNA Perspective on the Drivers of Genetic Diversity and Structure in Palearctic True Lemmings biorxiv.org 2026-06-16 True lemmings (genus Lemmus) underwent substantial range shifts during the Late Pleistocene and the Pleistocene-Holocene transition, but the impact of
High Quality Complete Genomes of Two Virulent Field Isolates of Pyricularia oryzae from Portugal biorxiv.org 2026-06-16 The fungal pathogen Pyricularia oryzae is notorious for causing blast disease in various important cereal crops, including wheat, rice, millet, and oa
A protocol for lab-scale production of 13C yeast extract as internal standard for metabolomics and quantification of intracellular metabolites biorxiv.org 2026-06-16 Metabolomics enables the profiling of small-molecule metabolites and thereby captures the biochemical state of a living organism at a given moment and
Molecular basis of SPRTN activation by DNA and ubiquitin biorxiv.org 2026-06-16 The promiscuous metalloprotease SPRTN is the key enzyme for proteolytic repair of DNA-protein crosslinks (DPCs).
Human metabolites modulate antifungal efficacy and reveal creatinine-mediated antagonism of flucytosine biorxiv.org 2026-06-16 Clearing fungal infections can fail, even when the causative pathogen is susceptible to antifungal drugs in vitro.
A Systematic Review and Independent Benchmarking of Automated Nerve Morphometry Methods biorxiv.org 2026-06-16 Objective: To systematically review automated nerve morphometry tools and independently benchmark their performance on independent optic nerve dataset
Physics-Informed Operator Learning for Pulsatile Milk Flow in Distal Generations of a Bifurcated Mammary Duct Network biorxiv.org 2026-06-16 Pulsatile milk transport through the lactating mammary ductal tree involves complex interactions between pressure gradients, wall compliance, and non-
Integrative Transfer Network: Deep Transfer Learning Across Populations and Prediction Targets biorxiv.org 2026-06-16 Large-scale clinical and biomedical datasets increasingly contain both diverse subgroup attributes (e.g., demographic or clinical subgroups) and multi
Transcriptional regulation of the rainbow trout spleen corticotropin-releasing factor system in response to inflammatory challenges: roles of NF-kB and cortisol biorxiv.org 2026-06-16 The corticotropin-releasing factor (CRF) system bidirectionally interacts with cytokines and other immune-related components in mammals.