Transposable elements underlie chromosomal fusions and fissions in a highly species-rich group of butterflies biorxiv.org 2026-06-17 Chromosomal fusions and fissions reshape karyotypes, recombination landscapes and patterns of speciation, yet the molecular mechanisms underlying thei
Holocentromere diversity in Cyperaceae: contrasting repeat organisation in Mapanioideae and Cyperoideae biorxiv.org 2026-06-17 Centromeres ensure accurate chromosome segregation and are typically confined to a single, localised region in monocentric chromosomes.
Autopolyploidization presents a transient and potential-rich window of increased transcriptional plasticity in Arabidopsis arenosa. biorxiv.org 2026-06-17 Whole-genome duplication (WGD, polyploidization) is a pervasive feature of Eukaryote evolution and often viewed as a source of evolutionary success an
Wolbachia facilitates the reproduction of a parthenogenetic ladybug biorxiv.org 2026-06-17 Wolbachia is a bacterial endosymbiont that is primarily transmitted from mother to offspring.
Evolutionary Coupling of Flagellar Motility and Type VI Secretion Systems Across Bacteria biorxiv.org 2026-06-17 Bacteria use both motility and antagonism to compete in spatially structured environments, but whether these traits evolve together across broad bacte
Predicted Effector Gene Aggregation, Standards and Unified Schema (PEGASUS): A Community Framework for Effector Gene Reporting biorxiv.org 2026-06-17 Genome-wide association studies (GWAS) increasingly report predicted effector genes (PEGs) - genes hypothesised to mediate the biological effects of a
Beyond phylogeny: Genome-wide DNA sequence patterns suggest DNA physical properties associated with thermal adaptation in extremophile microbes biorxiv.org 2026-06-17 Temperature is a fundamental constraint on biological systems, yet how it is reflected in genome sequence organization remains unclear.
Genetic manipulation of a giant virus-associated virophage biorxiv.org 2026-06-17 Virophages are double-stranded DNA viruses that hyperparasitize giant viruses infecting unicellular eukaryotes.
Does the evolution of predatory behaviour alter intermale aggression? Insights from a selection experiment on bank voles biorxiv.org 2026-06-17 Aggression occurs in many forms and can be an important adaptive behaviour. Two distinct forms are predatory and intermale aggression.
Cellular timing heterogeneity regulates phase transitions in living matter biorxiv.org 2026-06-17 Rigidity transitions govern tissue organization in ways reminiscent of inert materials.
A histidine switch controls the pH-responsive self-assembly of a helical protein filament biorxiv.org 2026-06-17 Self-assembling helical protein filaments underlie diverse biological processes, from signaling pathways to cell motility.
Warming limits energetic investment in feeding and post-feeding metabolism in bumblebees biorxiv.org 2026-06-17 Environmental warming is generally expected to increase metabolic demand in ectotherms.
Cocaine-Enriched Oral Streptococcus parasanguinis Promotes Neuroimmune Dysfunction and Memory Impairment biorxiv.org 2026-06-17 Chronic cocaine use is associated with neuroinflammation and cognitive dysfunction, but the underlying mechanisms remain unclear.
Discovery of Tcf7 regulators with clonally-resolved CRISPR screens identifies Trim28 as a mediator of CD8 T cell differentiation in tumors biorxiv.org 2026-06-17 Stem-like TCF7+ CD8 T cells sustain anti-tumor responses and support immune checkpoint blockade.
Hidden diversity and expanded host range of sarthroviruses, including terrestrial vertebrates biorxiv.org 2026-06-16 The Sarthroviridae are a family of highly compact satellite RNA viruses comprising one recognised species, extra small virus (XSV).
Implementing considered elements of standardisation for Time Kill Curve experiments across multiple sites: A European collaboration perspective biorxiv.org 2026-06-16 Background: The main advantages of Time Kill Curves (TKCs) in antimicrobial drug development are the ability to track bacterial kill and regrowth over
Magnetic field enables spin matching in spin-selective pathways to enhance current in bacteria biorxiv.org 2026-06-16 Electroactive bacteria export metabolic electrons through cytochrome-based extracellular electron-transfer (EET) conduits. Although purified S.
Migratory connectivity of pelagic predators between tropical Atlantic islands and seamounts revealed through passive acoustic telemetry biorxiv.org 2026-06-16 Oceanic islands and seamounts are recognised as hotspots of abundance and diversity for marine top predators, such as sharks and large teleosts, and a
Productivity drives demography and sex structure in a declining waterfowl species biorxiv.org 2026-06-16 Demographic models are crucial for uncovering the mechanisms underlying changing populations trajectories and structure and to identify the drivers of
Constant and variable warming differentially shape bacterial coexistence through phage-mediated interactions biorxiv.org 2026-06-16 Frequency-dependent predation helps maintain bacterial diversity, but its stabilizing role may be compromised under climate warming.
Automated Parameter Estimation for Camera Trap Density Models Using Computer Vision-Enhanced Distance Sampling biorxiv.org 2026-06-16 Models for estimating animal density from camera traps require four parameters informing detection: movement speed, daily activity level, staying time
Chromatin Assembly Factor 1 is required for normal structure and function of facultative heterochromatin in Neurospora crassa biorxiv.org 2026-06-16 Polycomb Repressive Complex 2 (PRC2) is a conserved epigenetic regulator that represses gene expression through methylation of histone H3 lysine 27 (H
LsBADH1 is responsible for sweet fragrance in lettuce (Lactuca sativa L.) through 2-acetyl-1-pyrroline biosynthesis biorxiv.org 2026-06-16 Fragrance is among the most valuable traits of high-quality crops and influences consumer preferences.
High-resolution cryoEM of nucleosomes in nuclear extracts of mammalian cells biorxiv.org 2026-06-16 Frontier Structural Biology methods are transitioning from analysis of reconstituted macromolecular complexes in vitro to imaging of macromolecular as
Efficient heterologous mRNA production in E. coli via protein-facilitated protection biorxiv.org 2026-06-16 Messenger RNA (mRNA)-based therapeutics have emerged as a new class of biological medicines, clearly exemplified by the global deployment of mRNA vacc
AutoZyme: An Autonomous Agentic Framework to Optimize Bioinformatics Software biorxiv.org 2026-06-16 Performance bottlenecks in widely used genomics and bioinformatics software present a substantial and growing burden as biological datasets continue t
Phylogenetic tree inference using generative models biorxiv.org 2026-06-16 Accurate inference of phylogenetic trees is fundamental to evolutionary biology, yet existing methods rely on complex pipelines involving multiple seq
DMcloud: Macromolecular Structure Modeling Using Local Structure Fitting for Medium to Low Resolution cryo-EM maps biorxiv.org 2026-06-16 Cryogenic electron microscopy (cryo-EM) has become an essential experimental approach in structural biology for determining macromolecular structures.
Structural basis of substrate recognition and allosteric inhibition in human B0AT2 biorxiv.org 2026-06-16 The SLC6 family is a major target for neuropsychiatric therapeutics.
The ultrasmall ocean microbiome: a reservoir of microbial diversity and nitrogen fixation. biorxiv.org 2026-06-16 Marine microbiology has long considered ultrasmall (<0.2 m) size fractions as virus-dominated, yet emerging evidence suggests potential prokaryotic