Stability and Compressibility of Tear Film Lipid Layer: Impact of Benzalkonium Chloride Presence biorxiv.org 2026-06-17 PURPOSE.: Benzalkonium chloride (BAK), a common preservative in eye drops, has a major side effect of dry eye.
Stratigraphic Paleobiology of Carbonate Systems biorxiv.org 2026-06-17 Stratigraphic paleobiology is a newly established interdisciplinary approach, which has demonstrated that the fossil record is a joint expression of b
Protein expression level of P2RY12 correlates with survival in Non-Small Cell Lung Cancer and exhibits diagnostic potential for Squamous Cell Carcinomas of the Lung biorxiv.org 2026-06-17 Context: P2Y12 receptor (P2RY12), mainly expressed on platelets, is known for its central role in hemostasis.
Reactivating a schizophrenia risk gene-enriched prefrontal ensemble suppresses decision noise biorxiv.org 2026-06-17 Schizophrenia genetics and single-cell transcriptomics implicate prefrontal excitatory neurons and synaptic programs, but how these vulnerabilities al
Ventricular Expansion Couples Hyperosmotic Stress to Thirst biorxiv.org 2026-06-17 Thirst is thought to arise from osmotic signals detected by circumventricular organs, yet how hyperosmotic stress activates mechanosensitive channels
Colorful connections: pigment-based plumage and breeding condition are associated with gut microbiome variation in the Common Yellowthroat biorxiv.org 2026-06-17 Carotenoid- and melanin-based plumage coloration traits are key signals in avian communication and sexual selection as they are often thought to provi
Global variations of Light Use Efficiency in Forests Jointly Driven by Plant Traits and Climatic Conditions biorxiv.org 2026-06-17 Forests are essential to the global carbon cycle with light use efficiency (LUE) as a key parameter for assessing carbon sequestration capacity.
Chemoselective Halogenation of Premarineosin A for Next-Generation Antimalarial Development biorxiv.org 2026-06-17 Premarineosin A undergoes rapid, chemoselective C12 halogenation under mild conditions, providing brominated, chlorinated, fluorinated, and iodinated
A DIA-based quantitative crosslinking mass spectrometryframework for dynamic structural proteomics biorxiv.org 2026-06-17 Proteins undergo dynamic conformational rearrangements and interactions that are central to their biological functions.
Q-DOAS: A Proximity Quenching Assay for Real-Time Detection of Early Protein Aggregation Events biorxiv.org 2026-06-17 Accurate measurement of protein aggregation is essential for studying neurodegenerative diseases.
Ubiquitin Chloromethylketone Probe Enables Activity-based, Selective Protein Profiling of E2 Ubiquitin Conjugating Enzymes biorxiv.org 2026-06-17 Ubiquitin (Ub) conjugating enzymes (E2s) are central to Ub signaling, yet their systematic activity-based profiling remains challenging due to the wea
Universal oligo adapters for high-efficiency DNA-barcoded antibody panel generation biorxiv.org 2026-06-17 DNA-barcoded antibodies are central to a broad range of spatial and dissociative assays and applications, including multiplexed imaging, single-cell p
Selectivity of Lateral Epidural Spinal Cord Stimulation with Varying Electrode Diameters and Stimulation Configurations biorxiv.org 2026-06-17 Objective.
MetaHarmonizer: robust biomedical metadata harmonization and a contamination control for inflated LLM performance on public benchmarks biorxiv.org 2026-06-17 Public biomedical repositories hold substantial reuse potential, but inconsistent metadata routinely blocks integration across studies.
Mechanosensitive Piezo Channels Contribute to Airway Changes in Chronic Obstructive Pulmonary Disease biorxiv.org 2026-06-17 As an intrinsically mechanosensitive organ, the lung experiences a range of mechanical forces.
Passive acoustic monitoring of Ensiferan calling diversity in a sub-tropical forest of Northeast India. biorxiv.org 2026-06-17 Ensiferans are nocturnal insects (Order Orthoptera) that produce mating advertisement calls using stridulatory organs on modified forewings.
A Structural Principle for Macroscopic Neural Dynamics Correlations biorxiv.org 2026-06-17 A central question in neuroscience is how the brain's structural connectivity gives rise to its emergent, correlated dynamics.
Uncovering Sex Differences in the Drosophila Ventral Nerve Cord Through Connectome Alignment biorxiv.org 2026-06-17 There are now multiple Drosophila connectomes available, comprising both its brain and spinal cord - comparing these connectomes requires first classi
Mass mortality of southern elephant seals during multi-species outbreak of HPAI H5N1 on sub-Antarctic Heard Island biorxiv.org 2026-06-17 High pathogenicity avian influenza (HPAI) has spread across the sub-Antarctic, causing significant wildlife impacts.
FALCON: Closed-Loop Multi-Objective Optimization of Lipid Nanoparticles for Cell-Selective mRNA Delivery biorxiv.org 2026-06-17 Efficient, cell type-selective delivery of genetic payloads remains a central challenge in the development of gene and cell therapies.
Advanced microfluidic strategy for In-Bead MSC spheroid formation and co-encapsulation of necrosis inhibitor-loaded nanoparticles biorxiv.org 2026-06-17 Mesenchymal stem/stromal cells (MSCs) are key players in regenerative medicine due to their immunomodulatory properties and ability to promote tissue
Parallel processing of orthogonal manifolds enables zero-shot composition in recurrent networks biorxiv.org 2026-06-17 Animals flexibly combine learned behaviors into novel actions without practicing their combinations, yet the computational mechanisms that enable inde
Azacytidine restores T cell function in AML by modulating DNA methylation biorxiv.org 2026-06-17 AML is an aggressive blood cancer associated with poor clinical outcomes.
SPACA9 Acts as a Molecular Staple Modulating Microtubule Dynamic Instability biorxiv.org 2026-06-17 Motile cilia rely on highly stable axonemal microtubules reinforced by microtubule inner proteins (MIPs) that form a network within their lumen, yet t
Annotation-Based Gene-Peak Links Improve Regulatory Network Prediction of Gene Expression in Human Kidney Multi-Omics biorxiv.org 2026-06-17 Abstract Background Linking distal regulatory elements to their target genes is a central problem for interpreting chromatin accessibility and other n
Effects of long-term fasting: longitudinal epigenetic responses in humans biorxiv.org 2026-06-17 Prolonged fasting induces marked metabolic adaptations, but whether such time-limited yet intensive interventions engage molecular processes related t
Towards Passive Dietary Monitoring: Dilated CNN-Based Meal Detection Using Ambulatory High-Resolution Electrogastrography biorxiv.org 2026-06-17 Background: Objective tools for longitudinal dietary monitoring, despite its importance in the health triad of diet, sleep, and exercise, remain limit
Experiment-free learning of exoskeleton assistance is not an unsolved problem biorxiv.org 2026-06-17 We present three quantitative methods: 1) estimation of exoskeleton mechanical power and energy ratio from published data, 2) a systematic review of t
Nanomechanics of Mandible Wear in Insects biorxiv.org 2026-06-17 Many animals rely on specialised mouthparts to process food.
Machine learning-guided olivetolic acid cyclase engineering enables tailored cannabinoid biosynthesis in yeast biorxiv.org 2026-06-17 Cannabinoids comprise a diverse class of bioactive natural products with important therapeutic potential, but efficient microbial production remains l