The optical origin of the human skin color 'banana' in CIELAB space biorxiv.org 2026-06-18 Human skin colors occupy a characteristic banana-shaped region in CIE L*a*b* space, but why skin color coordinates are restricted to this region and h
Parametric Engineering of Atrioventricular Living Valve Transplants biorxiv.org 2026-06-18 Diseases of the (mitral and tricuspid) atrioventricular valves (AVV), which regulate inflow from the atria to the ventricles, can result in severe obs
"Fuzzy specificity" shapes diazotroph diversity and composition in nodulating plants of the Southeastern USA biorxiv.org 2026-06-18 Nitrogen-fixing symbioses, particularly those occurring in root nodules, are among the most consequential mutualisms in natural and agricultural syste
Extreme conservation of cnidarian stinging cell identity despite 600 million years of evolution biorxiv.org 2026-06-18 Understanding how cells specialize is essential for reconstructing the diversification of life on earth.
No support for cell size as a driver of tissue-level metabolic rates at the upper limits of animal cell size biorxiv.org 2026-06-18 Evolutionary diversity in metabolic rate underlies differences in physiology, morphology, and life history across the tree of life.
Systemic degradation of repressive transcription factors gates gene expression and cell fate specification biorxiv.org 2026-06-18 While proteasomes are best known for eliminating defective proteins or turning off signaling pathways, they also enable crucial cellular activities.
A Master-Key DNA System Enabling Programmable Cross-Talks in Biomimetic Networks via An Artificial Chaperone biorxiv.org 2026-06-18 Biological systems operate through complex molecular networks programmed by genetic information; however, constructing artificial systems with multila
Adaptive Charge Modulation Enables Focal, Selective Spinal Cord Stimulation biorxiv.org 2026-06-18 Clinical neuromodulation primarily employs near-field low frequency electrical stimulation to activate neurons in the immediate vicinity of the electr
PTEN Subcellular Localization Dictates Function biorxiv.org 2026-06-18 Mutations in phosphatase and tensin homolog (PTEN) drive unregulated activation of the phosphatidylinositol-3-kinase (PI3K) pathway, resulting in neur
Striatal activity maintains a short-term action-outcome memory to guide future choice biorxiv.org 2026-06-18 Adaptive behavior requires animals to use the outcomes of recent actions (action-outcomes) to guide future decisions.
OPULATION CHARACTERISATION AND PROPAGATION STRATEGYFOR WILD Coffea eugenioides IN NYUNGWE AND CYAMUDONGO FORESTS, RWANDA: A field assessment of mother trees and an evidence-based seed-source pathway. biorxiv.org 2026-06-18 This report presents a field assessment of wild Coffea eugenioides, the diploid maternal progenitor of cultivated Arabica coffee, in Nyungwe Forest Na
Muscle Loss as a Foundational Step in the Development and Evolution of the Turtle Shell biorxiv.org 2026-06-18 Modern biodiversity is built on a series of disparate body plans whose origins are obscured by deep time.
Ancient admixture catalyzes homoploid hybrid speciation and intense genomic erosion in Asian langurs biorxiv.org 2026-06-18 Ancient admixture is a powerful catalyst for evolutionary innovation, yet its long-term genomic consequences for newly formed lineages remain poorly u
Hepatocyte-, but not myeloid cell-Rictor/mTORC2 deficiency moderately attenuates steatotic liver disease induced by intake of a choline-deficient, amino acid-defined high-fat diet biorxiv.org 2026-06-18 Previous studies have demonstrated that mechanistic target of rapamycin complex 2 (mTORC2) deficiency provides complete protection against steatotic l
Palaeoproteomic deconvolution of physical and genetic collagen mixtures biorxiv.org 2026-06-18 Species identification in palaeoproteomics relies on genome-derived protein sequences which are often poor-quality, and lacks tools to cope with multi
Beyond mean trabecular separation: decomposing metaphyseal marrow space into local trabecular spacing and marrow cavity expansion biorxiv.org 2026-06-18 Micro-computed tomography (CT) is widely used to assess trabecular bone microarchitecture, with trabecular separation (Tb.Sp) among the core parameter
Bayesian-enhanced closed-loop optimization of ultrasound protocols for targeted and precise neuromodulation biorxiv.org 2026-06-18 Low-intensity focused ultrasound (LIFU) is a promising neuromodulation modality, but challenges related to high response variability and the poorly un
Deciphering shared and divergent tissue architectures from cross-species spatial transcriptomics biorxiv.org 2026-06-18 The integration of spatial transcriptomics (ST) data across species is essential for cross-species and translational studies, but remains challenging
Benchmarking gene expression reconstruction from single-cell latent representations biorxiv.org 2026-06-18 Single-cell transcriptomics is typically modeled in low-dimensional latent representations that improve the signal-to-noise ratio of the data.
Acute hypercapnic stress modulates innate and learned defensive behavior biorxiv.org 2026-06-18 Survival depends on avoiding threats, a process shaped by experience and internal states.
Parallel basal ganglia and frontal cortical outputs differentially encode context-dependent evaluation and categorical commitment during choice biorxiv.org 2026-06-18 Adaptive choice requires transforming the evaluation of available options into commitment to a specific action but understanding how this transformati
A hippocampal neuroimaging signature of neurovascular insulin signalling links metabolism to mood biorxiv.org 2026-06-18 Depression is a leading cause of global disability and is increasingly linked to systemic metabolic dysfunctions, including insulin resistance.
The lysosomal cation channel TRPML1 regulates the oligodendrocyte cytoskeleton biorxiv.org 2026-06-18 Differentiating oligodendrocytes undergo dramatic morphologic alterations to transition from progenitors to mature oligodendrocytes that synthesize my
Early life Oxytocin treatment Attenuates Seizure Susceptibility in Male, but not Female, Fmr1-KO Mice biorxiv.org 2026-06-18 Fragile X syndrome (FXS) is the leading inherited cause of intellectual disability, and is frequently accompanied by seizures.
Distinct cortical patches for syntactic and semantic composition in the human brain biorxiv.org 2026-06-18 Although the brain areas for language processing are well delimited, whether lexical-semantic and syntactic processes are spatially segregated remains
Large-scale prediction of transcription factor binding across human cell types informs regulatory genomics and reveals promiscuous occupancy associated with chromatin contacts biorxiv.org 2026-06-18 Our understanding of the mechanisms regulating gene expression has been hampered by our limited knowledge of which transcription factors (TFs) bind wh
Sample preparation for mass spectrometry-based tissue (phospho)proteomics biorxiv.org 2026-06-18 This protocol describes the workflow for the preparation of tissue samples for proteome and phosphoproteome analyses using mass spectrometry.
Human striatal population state dynamics biorxiv.org 2026-06-18 Animal models reveal that striatal projection neurons (SPNs) fluctuate between discrete electrophysiological states with distinct levels of cortical i
Retinal cell mosaics in the valproate-induced rat model of autism spectrum disorder biorxiv.org 2026-06-18 Valproic acid (VPA) is a widely used antiepileptic drug that also increases the risk of neurodevelopmental disorders in the offspring of exposed mothe
Spatiotemporal Patterns and Structural Substrates of Individual Functional Variability in Youth biorxiv.org 2026-06-18 Youth is a period of emerging individuality and extensive neural remodeling, yet how functional brain individuality is organized across development re