A computational framework with voltage-dependent synaptic function explains LTP-dominant plasticity during functional electrical stimulation therapy biorxiv.org 2026-06-19 Functional Electrical Stimulation (FES) therapy is a widely used neurorehabilitation technique that restores motor function by delivering electrical s
Focal astrocyte Kir4.1 loss drives seizures, spreading depolarizations and postictal impairments biorxiv.org 2026-06-19 Astrocytic dysfunction is increasingly recognised as an important contributor to epileptogenesis and seizure dynamics.
OmniPath Metabo: chemical structures, interactions and mechanisms to study the metabolome biorxiv.org 2026-06-19 Mechanistic and functional analysis of omics data largely relies on the incorporation of prior knowledge; however, connecting metabolomics data and kn
SteerAF: Distogram-based Steering of AlphaFold2 toward Alternative Conformations biorxiv.org 2026-06-19 End-to-end structure predictors, such as AlphaFold2, typically output only the dominant conformational state of a given protein, which is biased by th
Terminal Schwann Cells Regulate Presynaptic Vesicle Homeostasis but Not Neuromuscular Junction Integrity in Mice biorxiv.org 2026-06-19 Terminal Schwann cells (tSCs) are specialized glial cells persistently residing at the neuromuscular junction (NMJ), where they are widely postulated
Sequential and coordinated control of human plasma cell differentiation by IRF4 and BLIMP1 utilizing a discriminating ISRE/EICE motif lexicon biorxiv.org 2026-06-19 The transcription factors IRF4 and BLIMP1 (PRDM1) promote plasma cell (PC) differentiation by repressing B cell identity genes while inducing the unfo
Detecting DNA methylation patterns suggestive of variable escape from X-chromosome inactivation biorxiv.org 2026-06-19 The X chromosome is often excluded from studies analyzing associations between traits and DNA methylation.
Antagonists Perturb the MC2R MRAP Complex and Reshape Receptor Conformations biorxiv.org 2026-06-19 Melanocortin 2 receptor (MC2R) is a G protein-coupled receptor (GPCR) for adrenocorticotropic hormone (ACTH), and its trafficking and signalling are a
Stochasticity and heterogeneity restrict tipping points and alternative stable states biorxiv.org 2026-06-19 Gradual environmental stress may trigger abrupt tipping points, trapping ecosystems in degraded states that are difficult to reverse.
Endosymbiont Wolbachia infection prevalence in biting midges of the family Ceratopogonidae in Southwest Asia: A Systematic Review and Meta-Analysis biorxiv.org 2026-06-19 Objectives To estimate the pooled prevalence of Wolbachia infection in biting midges (Ceratopogonidae) across Southwest Asia and to evaluate ecologica
Multiple introductions, trade-associated connectivity, and mito-nuclear discordance reveal complex invasion dynamics of Aedes albopictus in Colombi biorxiv.org 2026-06-19 Background Aedes albopictus is among the worlds most invasive mosquito species and an important vector of dengue, Zika, and chikungunya viruses.
Comparative pangenomics of Trypanosoma brucei reveal host specialization is driven by targeted or segmental genome streamlining in human and equine-restricted lineages biorxiv.org 2026-06-19 How the eukaryotic parasite Trypanosoma brucei remodels its genome during host specialization remains a fundamental question in evolutionary biology.
StickForStats: automated statistical assumption validation for reproducible computational biology biorxiv.org 2026-06-19 Reproducible computational biology depends on statistical decisions that routine workflows often skip: verifying that a differential-expression test's
Behavioral and neuronal dynamics in a rat model of obsessive-compulsive disorder biorxiv.org 2026-06-19 While cognitive and behavioral manifestations of obsessive-compulsive disorder (OCD) are well known, the neuronal dynamics underlying these symptoms r
Gravitational expectations simultaneously attract and repel perception biorxiv.org 2026-06-19 Perception is typically biased towards prior expectations.
Long-term isolation and introgression shape the genomic distinctiveness of Rice's Whale biorxiv.org 2026-06-19 Species' complex demographic history, including population size changes, isolation and gene flow, shapes patterns of genetic variation and deleterious
Fine-mapping candidate neuropsychiatric regulatory variants using cell type-aware comparative genomics biorxiv.org 2026-06-19 Measures of nucleotide sequence conservation across species are useful for identifying functional genomic loci, but can fail when regulatory function
Discovery of cell-active small molecule inhibitors of UDP-galactose 4'-epimerase biorxiv.org 2026-06-19 Glycosylation depends on tightly regulated pools of nucleotide-sugars (NS), yet the mechanisms controlling mammalian NS homeostasis and their downstre
Deep Learning-Based Reconstruction: Model Comparison for Variable-Density GRAPPA 1H MRSI biorxiv.org 2026-06-19 Proton magnetic resonance spectroscopic imaging (1H MRSI) enables quantitative mapping of brain metabolites, but its clinical use remains limited by l
Biodegradable Nanoparticle-in-Implant Platform for Sustained and Light-Boosted Pirfenidone Delivery biorxiv.org 2026-06-19 Vocal fold (VF) fibrosis is a major cause of persistent dysphonia due to excessive extracellular matrix deposition and tissue stiffening that disrupt
Microfluidic Platform for Drug Response Profiling in NSCLC Patient-Derived Organoids biorxiv.org 2026-06-19 Tumor models that recapitulate 3D architecture are essential for understanding how cellular organization and microenvironmental interactions govern th
MAE-UNETR++: Masked Autoencoder Pretraining for 3-D Lung Nodule Segmentation biorxiv.org 2026-06-19 Voxel-level annotation for volumetric medical imaging is expensive and difficult to scale, which makes training highcapacity 3-D segmentation models c
APOE4 Drives Uniquely Dysfunctional Human Microglial States in Alzheimer's Disease biorxiv.org 2026-06-19 Variation in APOE, notably the {epsilon}4 allele, profoundly shapes risk and severity of late-onset Alzheimer's disease (AD), yet how it remodels huma
Joint dog and wolf genealogies reveal the evolution of the canine genome biorxiv.org 2026-06-19 Dogs and their closest extant relative, the grey wolf, diverged around 30k years ago, but have since experienced complex histories of gene flow involv
Quantifying evolutionary novelty and design efficiency in generative genome design biorxiv.org 2026-06-19 Generative genome design models can now produce previously unobserved genome-length sequences, but assessing their capabilities is complicated by limi
Functional importance of a structurally encoded succinimide modification in a high-affinity solute-binding protein biorxiv.org 2026-06-19 Post-translational modifications usually occur under enzymatic control as a mechanism for regulation of protein activity or localization, but can also
Design and discovery of "tug-of-war" riboswitches biorxiv.org 2026-06-19 Riboswitches are compact regulatory RNAs that modulate gene expression by switching between mutually exclusive structures in response to binding diver
Microfluidic System for On-Demand Imaging of Organotypic Slices biorxiv.org 2026-06-19 Organotypic brain slice cultures (OSCs) provide a physiologically relevant model for recapitulating complex tissues in vitro.
Bioinstructive Orthogonally-crosslinked Ovoprotein Microgels for Modular Bioprinting biorxiv.org 2026-06-19 Bioprinting increasingly requires biomaterials that are not only printable, but structurally adaptive and biologically instructive.
Soil Resistomes in a Tropical Watershed are Indirectly Structured by Bacterial Community Interactions with Soil Properties biorxiv.org 2026-06-19 Soils are recognized as reservoirs of antibiotic resistance genes (ARGs) with the potential to transfer to clinical pathogens, creating antimicrobial