Caenorhabditis becei recombinant inbred lines (beRILs) reveal the scope of heritable variation within a gonochoristic nematode population. biorxiv.org 2026-06-21 Caenorhabditis nematodes are a powerful model clade for evolutionary genetics.
Using somatic data to aid germline clinical variant interpretation in developmental disorders biorxiv.org 2026-06-21 Accurate interpretation of rare germline variants remains a major challenge in developmental disorders (DD).
Consistent MYORG and STRADB Downregulation in DMD and LGMD: Rationale for Deoxygalactonojirimycing Repurposing in Dystrophic and Aging Muscle biorxiv.org 2026-06-21 Background: MYORG (myogenesis-regulating glycosidase) and STRADB (STE20-related kinase adapter protein beta) were previously identified as activity-me
Killiverse: an interactive multi-omics web resource for killifish biorxiv.org 2026-06-21 Background: Killifish have emerged as valuable vertebrate model systems for investigating several disciplines including aging, regeneration, and devel
ReSeT: a taxonomy-aware reference genome selection tool biorxiv.org 2026-06-21 Motivation: Reference genome composition determines which taxa a profiling pipeline can detect and distinguish, and becomes of critical importance for
Mechanical Checkpoint for Cell Division in Three-Dimensional Microenvironments biorxiv.org 2026-06-21 Cell division within mechanically confining extracellular matrices (ECMs) is a key regulator of tissue morphogenesis and cancer progression.
Changes in cuticle composition co-regulate drought and herbicide resistance in horseweed (Erigeron canadensis) biorxiv.org 2026-06-21 Horseweed (Erigeron canadensis) is a widely distributed annual weed that can cause significant yield losses if not properly controlled.
Live-cell imaging of enhancer-promoter dynamics reveals transient contact-driven gene activation biorxiv.org 2026-06-21 Enhancers are key regulators of mammalian gene expression, yet how they interact with promoters in space (contact vs.
Combination epigenetic-targeted therapy increases the immunogenicity of poorly immunogenic sarcomas biorxiv.org 2026-06-21 Immunotherapy approaches have shown limited efficacy in pediatric sarcomas, partly because these tumors have low mutation burden and few neoantigens.
Cytokines driven by caspase-1 and RIPK3 are antagonistic biorxiv.org 2026-06-21 Pyroptosis, apoptosis, and necroptosis are thought to provide redundant protection against intracellular pathogens.
Targeting the Mannitol Biosynthesis Pathway in Aspergillus fumigatus: Characterisation and Inhibition of Mannitol-2-Dehydrogenase biorxiv.org 2026-06-21 Infections caused by the opportunistic fungal pathogen Aspergillus fumigatus pose a serious public health system burden.
Evidence of maternal resilience in two mouse strains in the context of permanent mouse breeding strategies biorxiv.org 2026-06-21 Breeding female mice represent an essential but often overlooked workforce sustaining biomedical research.
First characterization of metabolomic and lipidomic exchange over the healthy human brain biorxiv.org 2026-06-21 The energy turnover and metabolic flexibility of the human brain extend beyond a primary reliance on carbohydrates and oxygen.
Integrative Multi-Omics Analysis of Gut Microbiota Dysbiosis and Host-Microbiome Interaction Mechanisms in Hypertension biorxiv.org 2026-06-21 Objective:To characterize gut microbiota dysbiosis in hypertension and investigate its multilevel interactions with the host immune system.
Identification of heterotic group-specific haplotypes and impact of residual inbreeding on grain yield of maize elite hybrids biorxiv.org 2026-06-21 Modern hybrid maize (Zea mays L.) breeding programs are based on the management of distinct complementary heterotic groups to maximize heterosis in hi
Antibody-Antigen Affinity Prediction with Chain-Aware Protein Language Modeling biorxiv.org 2026-06-21 Motivation: Antibody-antigen affinity determines which antibodies advance in therapeutic discovery, repertoire analysis and affinity maturation, but e
A novel preclinical mouse model recapitulates progressive phenotypes of Bryant-Li-Bhoj Syndrome biorxiv.org 2026-06-20 Bryant-Li-Bhoj Syndrome (BLBS; OMIM: 619720, 619721) is a Mendelian neurogenetic condition, first described in 2020, with a mixed neurodevelopmental/n
Long-term population decline and recombination heterogeneity shape genomic diversity in the American alligator biorxiv.org 2026-06-20 The loss of genetic diversity caused by population bottlenecks can significantly impact the ability of a species to adapt to disease, natural disaster
Genetic Modulation of Oxycodone Self-Administration Trajectories: From Initiation to Escalating Burst Patterns biorxiv.org 2026-06-20 Opioid Use Disorder (OUD) remains a prominent threat to global health.
SAbDab2: The structural antibody database in the age of machine learning biorxiv.org 2026-06-20 The Structural Antibody Database (SAbDab) is a publicly available repository of experimentally determined antibody structures, first released in 2013.
MIRATS framework: Normative multiscale characterization of brain regulatory systems across sex and age using multimodal MRI biorxiv.org 2026-06-20 Deep brain systems involved in arousal, autonomic regulation, sensory integration, and homeostatic control remain underrepresented in conventional who
Evaluation of Trypanosoma brucei Phosphofructokinase Allosteric Inhibition: An In-Silico Study biorxiv.org 2026-06-20 Human African trypanosomiasis, caused by a protozoan parasite Trypanosoma brucei, is a neglected tropical disease for which well-tolerated, convenient
RNAStabFormer: Region-Aware Multi-Task Hybrid Learning for RNA Stability Prediction from Pulse-Chase Transcriptomics biorxiv.org 2026-06-20 RNA stability is a central layer of post-transcriptional gene regulation, yet large-scale stability labels derived from pulse-chase transcriptomics de
Non-contact direct sensing of material properties of biomolecular condensate using Scanning Ionic Conductance Microscopy biorxiv.org 2026-06-20 Biomolecular condensates are important regulators of cellular compartmentalization and biochemical processes.
Viral RNAs as Dual Graphs: Extending the Motif Universe of RNAs biorxiv.org 2026-06-20 In the evolving landscape of RNA research, the classification and analysis of RNA motifs is necessary to uncover the intricate mechanisms governing ce
Multiple routes to red-shifted chlorophyll d-based photosynthesis biorxiv.org 2026-06-20 Strains of the cyanobacterium Acaryochloris marina exhibit diverse far-red light-harvesting properties during chlorophyll d-based photosynthesis.
Defining reversible binding rates in 1D systems dependent on diffusion, density, and excluded volume biorxiv.org 2026-06-20 Binding reactions in effectively one-dimensional systems, such as proteins diffusing along DNA or other filaments, pose a fundamental coarse-graining
Dose-Dependent Softening of Bacterial Model Membranes by Structurally Distinct Antimicrobial Peptides: A Coarse-Grained Molecular Dynamics Study biorxiv.org 2026-06-20 Antimicrobial peptides (AMPs) act at the membrane interface, where they remodel lipid packing defects and redistribute lateral stresses, yet a quantit
Reach-and-hold at a musculoskeletal arm posture is an unstable-equilibrium stabilization problem: the limits of fixed equilibrium-point and impedance controllers biorxiv.org 2026-06-20 Holding a redundant limb at a commanded posture against gravity is a basic problem in musculoskeletal motor control.
Characterisation of Peripheral Blood B Cell Receptor Repertoire in Severe Eosinophilic Asthma and EGPA biorxiv.org 2026-06-20 Background: Severe eosinophilic asthma (SEA), eosinophilic granulomatosis with polyangiitis (EGPA) and nasal polyposis (NP) are immune-mediated diseas