An aorta to insulin producing cell sensor for internal state in Drosophila biorxiv.org 2026-06-22 The cellular circuits through which the internal state of an organism is sensed and relayed to the brain, and through which they bring about appropria
Parental transport induces a dormant state while maintaining oxytocin recruitment in poison frog tadpoles biorxiv.org 2026-06-22 Parental care can have pervasive effects on offspring neurodevelopment.
Human dental pulp stem cells grafted into C57BL/6J hippocampus differentiate towards immature neuronal like cells displaying action potential firing activity biorxiv.org 2026-06-22 Stem cell therapy represents a promising strategy for the replacement and functional restoration of damaged neural tissue in neurodegenerative conditi
Decoding Chronic Pain States from Distributed Intracranial Recordings biorxiv.org 2026-06-22 Chronic pain engages distributed cortical and subcortical circuits, and large-scale intracranial recordings in humans offer a valuable opportunity to
Visual uncertainty and task demands shape active sensing strategies in mice biorxiv.org 2026-06-22 In natural environments, animals actively sample visual information to guide behavior.
Seeing the world in a grain of sand: Fine global and local representations in foveal and parafoveal vision biorxiv.org 2026-06-22 Foveal vision enables primates to perceive small objects with remarkable precision by resolving both global form and fine local detail.
Early Vision Shapes Recurrent Processing in the Human Visual Cortex biorxiv.org 2026-06-22 Recurrent processing involves feedforward, feedback and lateral connections and is thought to allow efficient visual processing.
Ballistic food approaches in Parhyale hawaiensis require the antennae biorxiv.org 2026-06-22 Many arthropods (insects and crustaceans) rely on their antennular chemosensory system to detect key environmental resources like food.
Rapid and divergent changes in the continental-scale organisation of a short-lived songbird's migratory strategy biorxiv.org 2026-06-22 It is hard to predict how rapidly songbird migration will change in the Anthropocene.
Healing cascades and infections in wounds monitored using a wearable sensor of gaseous flux biorxiv.org 2026-06-22 Capabilities for quantitative monitoring of chronic wounds remain an unmet clinical need, as existing diagnostic approaches rely on semiquantitative e
The Burger Battle: The Future is Blended biorxiv.org 2026-06-22 Texture is one of the major barriers to acceptance of sustainable protein products, yet the relationship between instrumental texture and consumer per
EventHorizon: A Foundation Model for Clinical Flow Cytometry biorxiv.org 2026-06-22 Flow cytometry is an essential tool for diagnosis of hematologic malignancies, but existing clinical workflows are highly dependent on expert manual i
Upregulation of ATP-purinergic P2x2 receptors in the cochlea over-amplifies hearing sensitivity leading to hyperacusis and attenuation by antagonists biorxiv.org 2026-06-22 Hearing hypersensitivity (hyperacusis) is a common hearing stress and can cause many psychological diseases, e.g., anxiety, learning disabilities, and
Metabolomic Network Analysis Reveals Reorganization of Lipid and Steroid Programs Linked to Right Ventricular-Pulmonary Vascular Function in Pulmonary Hypertension biorxiv.org 2026-06-22 Background: Pulmonary arterial hypertension (PAH) is characterized by circulating metabolic alterations, but whether these reflect disease-specific me
Nucleotide-driven KaiC dynamics coordinate the core properties of the cyanobacterial circadian clock biorxiv.org 2026-06-22 Circadian clocks generate stable ~24-h rhythms with a defined period, temperature compensation, and entrainment to external cues that set phase.
Response diversity inconsistently predicts functional robustness to simulated zooplankton extinctions biorxiv.org 2026-06-22 Ecosystem functioning can be maintained in species-rich communities even under fairly severe perturbations.
NicheDiv: A DAPC framework to quantify niche divergence across highly multivariate environmental space biorxiv.org 2026-06-22 Quantifying niche divergence is crucial to understanding the ecological and evolutionary processes underlying range limits, coexistence, speciation, b
Capturing early events in aryl hydrocarbon receptor activation using two complementary protein-protein interaction assays biorxiv.org 2026-06-22 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that enables cellular adaptation to environmental, nutritional and meta
Mechanical tension expands the microtubule lattice stepwise and modulates kinesin-1 binding in an isoform-dependent manner biorxiv.org 2026-06-22 Recent work has shown that the microtubule lattice possesses remarkable structural plasticity, with its conformation modulated by microtubule-associat
Cell division dynamics generate heterogeneous contact-mediated signaling outputs biorxiv.org 2026-06-22 Contact mediated cell-cell communication where direct physical contact between adjacent ligand cells and receptor cells trigger signal output is impor
Urbanization effects are trait-specific and city-dependent across a widespread spider's global range biorxiv.org 2026-06-22 Urban environments impose strong selective pressures through biotic and abiotic factors, driving changes in behavior, physiology, and morphology.
Microbial succession in West African secondary forests: rapid internal stabilisation without convergence toward old-growth reference states biorxiv.org 2026-06-22 Secondary forest succession following agricultural abandonment is a dominant land-use transition across the tropics, yet whether soil microbial commun
Data requirements for accurate extinction-risk prediction in bistable populations biorxiv.org 2026-06-22 Understanding and predicting extinction risk is a central challenge in population biology.
A global analysis of climate-driven reversal risks in forests biorxiv.org 2026-06-22 The integrity of forest-based climate solutions and carbon credits requires persistent carbon storage, but climate change is increasing the risk of na
kontakteUR: transforming coordinates to chemical intuition to focus on essential interactions in biomolecular systems biorxiv.org 2026-06-22 Molecular interactions govern cellular function, making them essential to discover biomolecular mechanisms by unravelling structure-function relations
Structural and functional insights into yeast Rqc1p, a protein required for thermotolerance with potential nuclear localization biorxiv.org 2026-06-22 Protein homeostasis (i.e., proteostasis) is the biological process by which the qualitative and quantitative balance of the proteome is conducted, eit
Near-Infrared Turn-On Fluorogenic Probe for Versatile Detection of Inorganic Polyphosphates biorxiv.org 2026-06-22 Inorganic polyphosphate (polyP) is a ubiquitous phosphate biopolymer involved in diverse cellular processes.
Systematic Quantitative Proteomics Defines Age, Sex, and Region-Dependent Remodeling of Lung Extracellular Matrix biorxiv.org 2026-06-22 The lung extracellular matrix (ECM) governs tissue architecture, mechanics, and function, yet how it remodels with age across sex and anatomical regio
Structural basis of microtubule destabilization by GTP hydrolysis biorxiv.org 2026-06-22 Microtubules are cytoskeletal filaments that dynamically grow and shrink to support vital biological functions.
Stress Granule Coarsening Is a Pathological Inflection Point for Cardiac Electrophysiological Dysfunction biorxiv.org 2026-06-22 Arrhythmia risk rises early in many forms of cardiac stress, often before contractile failure is evident.