Spreading α-synuclein rewires organelle communication and impairs neuron-astrocyte mitochondrial quality control biorxiv.org 2026-06-23 Progressive intercellular spreading of -synuclein (S) is implicated in pathology initiation and propagation of synucleinopathies.
PIGMENT: A deep learning framework for Porcine Immunohistochemistry seGMENTation biorxiv.org 2026-06-23 Traumatic brain injury produces widespread axonal damage can be assessed histologically using amyloid precursor protein (APP) immunohistochemistry, wh
Ciliary integrity defines a central canal repair checkpoint linking microtubule stabilization to spinal cord regeneration biorxiv.org 2026-06-23 Microtubule-stabilizing agents consistently improve functional recovery after spinal cord injury (SCI), yet the structural mechanism underlying their
Complex interplay of biomechanics and ecology influenced crab claw morphology evolution biorxiv.org 2026-06-23 True crabs (Brachyura) are among the most iconic marine arthropods, representing noteworthy examples of morphological and ecological disparity (1, 2).
Tiny Subsamples and Upsampling Tame Big Data Evolutionary Analysis in Phylogenomics biorxiv.org 2026-06-23 Long runtime, high memory demands, and reliance on high-performance computing increasingly limit the evolutionary analysis of long phylogenomic datase
Targeting Dengue Virus NS3 Helicase: Biochemical and Computational Evaluation of Catechins from Camellia sinensis as Potential Therapeutic Leads biorxiv.org 2026-06-23 Dengue Virus Serotype 2 is a human pathogenic flavivirus that encodes a non-structural protein 3 (DEN2-NS3) containing a helicase domain essential for
Fluorescence Blinking Patterns Fingerprint the Local Protein Environment biorxiv.org 2026-06-23 The function of a protein depends not only on its sequence but on post-translational modifications and folding that produce functionally distinct prot
Genomic and Kinetic Modeling Involving Nanoparticle-Mediated Delivery of a Novel Chitinase Enzyme to Outpace Tuta absoluta Damage biorxiv.org 2026-06-23 The tomato leafminer, Tuta absoluta, poses a severe global agricultural threat due to its rapid leaf-mining behavior and swift development of resistan
Phase-tuned interfacial condensates drive transcellular access biorxiv.org 2026-06-23 Life has evolved the plasma membrane as an active physicochemical interface rather than a passive barrier, one whose selectivity sustains homeostasis
AutoBlot: deterministic single-cell western blotting reveals proteomic diversity in rare cell populations biorxiv.org 2026-06-23 Single-cell western blotting (scWB) provides quantitative, molecular-mass-resolved protein measurements but relies on Poisson-limited gravity settling
Elemental Analysis of Herbal Food Supplements using ICP-MS for Toxicant and Nutritional Profiling biorxiv.org 2026-06-23 Botanical dietary supplements (like wheat, barley, teff, oats, white lupin, pumpkin seed, and chickpeas) may contain trace amounts of toxicants in add
Lichen Growth Form Effects on Rock Weathering in Cold Biomes biorxiv.org 2026-06-23 Rock surface weathering is a critical element in the process of early soil formation, in which lichens are thought to play a significant role.
Impact of Amazonian protected areas in preventing deforestation and carbon loss over four decades biorxiv.org 2026-06-23 Native vegetation protection is a key strategy for delivering both biodiversity and climate benefits, and protected areas have been widely adopted to
Mitochondrial Lon protease couples substrate translocation to proteolytic activation biorxiv.org 2026-06-23 Human LonP1 is an ATP-dependent mitochondrial protease that degrades damaged or redundant proteins.
Intrinsic representational drift from predictive excitatory-inhibitory plasticity biorxiv.org 2026-06-23 Neural representations drift gradually over time even under stable environmental conditions, but the synaptic mechanisms driving this drift remain unc
Characterisation of Posterior Predominant Amyloid PET Binding Across Multiple Cohorts biorxiv.org 2026-06-23 The standard approach to quantify amyloid (A{beta}) PET averages uptake within a single cortical mask that assumes no clinically relevant spatial hete
Electrolytic-Microbubble Dynamics Delineate Safety Thresholds During Intracortical Microstimulation with Flexible Neural Interfaces biorxiv.org 2026-06-23 Intracortical microstimulation (ICMS) with ultraflexible neural electrodes enables low-threshold, chronically stable, and high-resolution modulation o
Age Alters the Relationship between Post-Encoding Sleep Quality and Context Memory Neural Reinstatement biorxiv.org 2026-06-23 Sleep supports episodic memory consolidation, yet it remains unclear how naturalistic post-encoding sleep quality relates to the neural reinstatement
Acoustic Characteristics of Low-Frequency Vocalizations of Bryde's Whales (Balaenoptera edeni edeni) in the Weizhou Island Waters of the Beibu Gulf, China biorxiv.org 2026-06-23 Bryde's whales (Balaenoptera edeni edeni) are nationally protected in China, and the waters around Weizhou Island in the Beibu Gulf support one of the
Systematic benchmarking of zero-shot utility and robustness in single-cell transcriptomic foundation models biorxiv.org 2026-06-23 Single-cell foundation models (scFMs) have been proposed as reusable representations for transcriptomic analysis, yet their practical utility and robu
CellOS: Learning a World Model of Cellular State through Joint Embedding Prediction biorxiv.org 2026-06-23 Foundation models learned from single-cell transcriptomes are central to the prospect of AI virtual cell that can represent, query and predict cellula
The Metabolic Scope Theory of Aging: Rising Mitochondrial Impedance Compresses Metabolic Reserve to Constrain Lifespan biorxiv.org 2026-06-23 Maximum lifespan varies more than 100-fold across vertebrates, yet within each species aging emerges as a coordinated syndrome spanning metabolism, im
Transplanted human photoreceptors differentially survive, incorporate, and mature in mildly and severely degenerated mouse retinae biorxiv.org 2026-06-23 Photoreceptor transplantation is considered a disease-agnostic therapeutic strategy for retinal degenerative diseases with highly heterogenous genetic
ABCA7 rs3752231 variant effects on glial responses to amyloid-β and plaque maturation in Alzheimer's disease. biorxiv.org 2026-06-23 Variants in ABCA7 are among the most consistently replicated genetic risk factors for late-onse Alzheimer's disease (AD), yet the cellular mechanisms
Insect-inspired, efficient event-based classification of tactile features biorxiv.org 2026-06-23 Tactile sensing enables humans and animals to detect and discriminate features during exploration and guide context appropriate actions.
Co-existence of Modularity and Anti-modularity in the Functional brain connectomes biorxiv.org 2026-06-23 The brain requires coordination among different regions to execute cognitive tasks, which may involve both positive- and negative-correlations.
PERIODIC AND APERIODIC SPECTRAL SIGNATURES OF BEING MOVED BY ART biorxiv.org 2026-06-23 Intense aesthetic experiences are among the most complex responses arising from the interaction of mind, brain, and context.
Improving the detection sensitivity of calcium transients in densely labeled neuronal tissue with pinhole illumination - A low-cost approach biorxiv.org 2026-06-23 Optical recording from large numbers of neurons is an indispensable technique for studying neuronal ensembles.
Intravenous midazolam alters short-interval paired-pulse TMS responses differently in younger and older adults biorxiv.org 2026-06-23 Objective: Aging is associated with changes in cortical excitability and altered responsiveness to benzodiazepines, but the effects of benzodiazepine
Distinct Endosomal Sorting Complexes Required for Transport Components Differentially Regulate Glutamate and Gamma-Aminobutyric Acid Receptor Surface Expression biorxiv.org 2026-06-22 Endosomal sorting complexes required for transport (ESCRT) regulate membrane protein trafficking through coordinated cargo selection and endosomal pro