Large-scale meta-analysis of over one million individuals reveals the genetic architecture of 127 complex traits in East Asian populations biorxiv.org 2026-06-23 Genome-wide association studies (GWASs) have disproportionately focused on European (EUR) populations, limiting the characterization of genetic archit
EnrichViz: An Interactive R Shiny Application for Visualization of Pathway Enrichment Results from Omics Data biorxiv.org 2026-06-23 Pathway and functional enrichment analysis is a cornerstone of omics data interpretation, enabling researchers to map differentially expressed protein
Measuring peptide-MHC generalization to unseen alleles across both HLA classes biorxiv.org 2026-06-23 Reported peptide-MHC (pMHC) AUROCs of 0.85-0.95 overstate generalization to unseen alleles: because immunopeptidome data are dense on a few well-studi
VCBench: A Multi-Dimensional Benchmark for Single-Cell Foundation Models biorxiv.org 2026-06-23 Single-cell foundation models are increasingly positioned as virtual cells, yet their capabilities are assessed by fragmented, largely single-task ben
Learning interpretable structural similarity from tandem mass spectra for small molecule analog discovery biorxiv.org 2026-06-23 Analog discovery remains a central bottleneck in mass spectrometry-based untargeted metabolomics, as conventional spectral similarity scores poorly re
Comorbidity structure as an inductive bias: Comparing output-head designs for multi-label prediction of diabetes and myocardial infarction complications biorxiv.org 2026-06-23 Background: Clinical complications are often predicted with separate sigmoid outputs, even when the target labels arise from related pathophysiologica
Modular in vitro evaluation of Buparlisib-polymeric nanomedicines in 2D and 3D models of glioblastoma biorxiv.org 2026-06-23 Introduction: In this study, we developed a modular in vitro platform that integrates advanced polymer-drug conjugation chemistry with stepwise cytoto
Obesity-induced changes in ultrastructure and calcium release of female rat cardiomyocytes are partially reversed by aerobic exercise biorxiv.org 2026-06-23 Obesity is associated with an elevated risk of pathological cardiac hypertrophy, whereas exercise confers cardioprotective effects; however, the cellu
Severely lipoatrophic mice are hypermetabolic and hyperthermic under thermoneutral conditions in part due to an enhanced liver de novo lipogenesis biorxiv.org 2026-06-23 White, beige and brown adipocytes store energy as lipids, secrete hormones and produce heat, playing an important role in the regulation of energy bal
Exercise training improves exercise capacity independent of AMPKa2 T172-mediated adaptations in skeletal muscle biorxiv.org 2026-06-23 Regular exercise induces adaptations in skeletal muscle and other organ systems to improve physical performance and overall health.
p38β/MAPK11 Deficiency Exacerbates Cardiac Structural and Electrophysiological Remodeling and Contributes to Immune Dysregulation in the Aging Heart biorxiv.org 2026-06-23 Aging is a major risk factor for cardiac diseases, including heart failure, myocardial infarction, and arrhythmias.
Automated detection of blink reflexes evoked by optogenetic stimulation of TRPV1-expressing corneal nociceptors in transgenic mice biorxiv.org 2026-06-23 Background Conventional rodent models for the study of corneal pain commonly evoke eye blink reflex using methods that indiscriminately activate polym
SpikeCleaner: An Algorithm to Label Unit Quality After Automated Spike Sorting biorxiv.org 2026-06-23 ABSTRACT Gap: Automated spike sorting algorithms have revolutionized the way neuronal activity is extracted from extracellular recordings, yet they re
Graph-based characterization of in vitro neuronal network maturation using machine learning and digital holographic microscopy biorxiv.org 2026-06-23 Significance: Digital Holographic Microscopy (DHM) provides label-free quantitative phase images (QPIs) of living cells and has become a powerful tool
Gaming Addiction Transmission: Interpersonal Neural Pathways Revealed by HYPER-NESS biorxiv.org 2026-06-23 Gaming addiction may be contagious through social interaction.
Multisensory integration of stimulus-driven and goal-driven signals during urgent saccadic choices biorxiv.org 2026-06-23 The ability to orient or attend to sensory events is generally greater in response to visual and auditory cues occurring together than in response to
Mapping Lifespan Trajectories of Cognitive Flexibility with a Continuous Probabilistic Reversal Learning Measure biorxiv.org 2026-06-23 Cognitive flexibility is the ability to change the way of responding when the demands of the environment change.
Ventral pallidal GABAergic neurons control hedonic feeding and obesity biorxiv.org 2026-06-23 Food intake is governed by two interacting drives.
Discrete Cognitive Resolution in Alzheimer's Disease: Cross-Cohort Reanalysis of ADNI and NACC Longitudinal Data biorxiv.org 2026-06-23 INTRODUCTION: Do continuous cognitive totals capture patient-relevant transitions, or does decline have discrete structure?
ComCat: Combating Covariate Effects in Brain Analysis biorxiv.org 2026-06-23 As neuroimaging analysis shifts toward large-scale, multi-site studies, managing the unwanted variability introduced by combining heterogeneous datase
Representational similarity analysis of EEG reveals multiple spatiotemporal dynamics of selective attention biorxiv.org 2026-06-23 Selective attention allows listeners to follow a target speaker in complex scenes, but less is known about the neural mechanisms that control this cap
Elastin-derived peptides suppress CCL20 expression and block ILC2 recruitment during lung inflammation biorxiv.org 2026-06-23 Elastin degradation during chronic lung inflammation generates elastin peptides (EPs) with immunomodulatory properties.
replicateFest: An R Package and Shiny App for Analysis of T Cell Receptor Repertoire Data from the Functional Expansion biorxiv.org 2026-06-23 Motivation: The Functional Expansion of Specific T cell (FEST)-based assays combine short-term peptide stimulation with TCR sequencing to identify clo
Human CD8-iTreg are potent GVHD suppressors and tumoricidal effectors by release of Granzyme-K+ Supramolecular Attack Particles biorxiv.org 2026-06-23 Regulatory CD8+ T-cells (CD8+ Treg) are a distinct yet understudied T-cell subset capable of simultaneous immunosuppression and cytolysis.
A microbial metabolite reduces alcohol-induced inflammation via dual modulation of NF-κB and Interferon pathway biorxiv.org 2026-06-23 Abstract Background and aims: Alcohol-associated hepatitis (AH) is characterized by excessive inflammation and blunted antiviral interferon (IFN) resp
gamdid: generalized additive models for differential distributions in single cell experiments biorxiv.org 2026-06-23 Single-cell proteomics (SCP) generates protein abundance measurements across hundreds to thousands of individual cells, offering unprecedented resolut
Protocol-Guided Cross-Domain Transfer Learning for Bovine Facial Pain Recognition under Weak Dairy-Farm Labels biorxiv.org 2026-06-23 Livestock welfare models are developed under controlled experimental conditions but deployed across farms, breeds, management systems and label regime
Power-Law Adaptation Stabilizes Primary Sensory Encoding of Natural Variance biorxiv.org 2026-06-23 Natural physical environments constantly fluctuate across multiple timescales, often following a scale-free ($1/f^alpha$) pattern where $alpha = 0.5$
Ocean acidification changes diet effects and differentially impacts two populations of red abalone (Haliotis rufescens) biorxiv.org 2026-06-23 Absorption of CO2 by global oceans is decreasing pH resulting in ocean acidification (OA).
Allosteric Modulation of β1 Integrin Attenuates Motor Asymmetry in the Unilateral 6-Hydroxydopamine Injury Model in Mice biorxiv.org 2026-06-23 Parkinson's disease (PD) is characterised by progressive dopaminergic neurodegeneration in the substantia nigra, leading to debilitating motor dysfunc