BGC-QDR: A Quantum-Assisted Pipeline for Biosynthetic Gene Cluster Discovery and Ranking from Environmental DNA biorxiv.org 2026-06-25 Biosynthetic gene clusters (BGCs) encode enzymatic pathways for natural products with pharmaceutical potential, yet prioritizing candidates from fragm
Tissue-aware elastic net decomposition reveals shared and lineage-specific drug response biomarkers biorxiv.org 2026-06-25 Motivation: Computational models that predict cancer drug response from genomic features are central to biomarker discovery, yet a recent audit found
NanoCellAnnotator: Formalizing Expert Cell Type Annotation with Large Language Models biorxiv.org 2026-06-25 Motivation: Cell-type annotation in spatial transcriptomics is challenging due to sparse gene panels, spatial heterogeneity, and limited availability
CREPAS: a reproducible nascent chromatin sequencing analysis pipeline for epigenome replication studies biorxiv.org 2026-06-25 Chromatin-based genomics data are essential for understanding genome regulation and the mechanisms underlying epigenetic memory.
A Visually Interpretable Histopathology-Based Immune Model Predicts T-effector Biology and Response to Immune checkpoint inhibition in Clear Cell Renal Cell Carcinoma Clinical Trial and Contemporary Real-World Datasets biorxiv.org 2026-06-25 Immune checkpoint inhibitors (ICI) are central to the treatment of metastatic clear cell renal cell carcinoma (ccRCC), yet only a subset of patients d
Ambiguity-Aware Multi-Stage Cell-Type Annotation for Spatial Transcriptomics biorxiv.org 2026-06-25 Spatial transcriptomics enables characterization of cellular organization in intact tissue, but robust cell type annotation remains challenging due to
Evidence for post-allopolyploidy genetic exchanges between duplicated regions in three ancient polyploidies biorxiv.org 2026-06-25 Many successful lineages, including flowering plants and vertebrates, owe some of their evolutionary prosperity to whole genome duplications (WGD).
GenoSim: A Forward-Time Genotype Simulator for Clinical and Population Genetics with Population Stratification biorxiv.org 2026-06-25 Motivation: Next-generation sequencing studies in clinical genetics are often limited by the scarcity of human genotype data, which stems from ethical
Interplay Between Protein-RNA Binding and Phase Separation Drives Emergent Behavior in RNP Condensates biorxiv.org 2026-06-25 Protein-RNA binding and biomolecular condensation are two key processes underlying the assembly and function of ribonucleoprotein (RNP) condensates.
The Staphylococcus aureus carotenoid staphyloxanthin modifies the structure of phosphoglycerol lipid bilayers biorxiv.org 2026-06-25 Staphyloxanthin (STX) is a carotenoid synthesized by the human pathogen Staphylococcus aureus.
Scalable Plasmonic Metasurface-Enabled Physics-Guided Self-Supervised Cellular Imaging biorxiv.org 2026-06-25 High-quality cellular imaging, especially in live cells, remains constrained by the trade-off among signal-to-noise ratio, phototoxicity, and instrume
F.A.D.E. (Fully Agentic Drug Engine): A Conversational AI Platform for Drug Discovery biorxiv.org 2026-06-25 Drug discovery remains one of the costliest and most time-intensive endeavors in the pharmaceutical pipeline, with average development costs exceeding
A Zebrafish Platform to Model Human SCN2A and SCN8A Epilepsy and Evaluate Anti-Seizure Medications biorxiv.org 2026-06-25 Many patients with epilepsy have inadequate seizure control using current anti-seizure medications (ASMs), illustrating the need for new treatments.
Dynamic resource allocation orchestrates physical simulation in the human brain biorxiv.org 2026-06-25 Humans can flexibly predict physical events by internally simulating object dynamics in the brain, a capacity lacking in current AI systems.
A humanized Galleria mellonella model reveals prophage-mediated breakdown of colonization resistance against Salmonella biorxiv.org 2026-06-25 Background Colonisation resistance provided by the gut microbiota is a critical barrier to pathogen invasion, yet its study in vivo is constrained by
Intracellular amino acid scarcity sensing tunes protein hunger biorxiv.org 2026-06-25 Protein is a key macronutrient that strongly governs food intake.
NeuroEnergetics-on-Chip: a novel 3-compartment microfluidic platform to study metabolic interactions between brain parenchyma and cerebral vasculature biorxiv.org 2026-06-25 Neurological disorders are a major cause of death and disability worldwide.
Decomposition of task-specific responses in the multiple demand network biorxiv.org 2026-06-25 Neuroimaging evidence suggests that a distributed network of brain areas, known as the multiple demand (MD) network, is consistently recruited across
Dopamine projections to the basolateral amygdala enable reward prediction biorxiv.org 2026-06-25 Reward predictions are critical to both adaptive learning and decision making.
A p53-ΔNp73 signaling axis drives selective motor neuron degeneration in spinal muscular atrophy biorxiv.org 2026-06-25 Selective neuronal vulnerability is a hallmark of many neurodegenerative diseases, yet how ubiquitous genetic insults cause highly selective neuronal
ST3GAL3 loss-of-function disrupts synaptic integrity and excitatory/inhibitory cortical dynamics biorxiv.org 2026-06-25 This study examined the role of ST3GAL3 as a regulator of excitatory/inhibitory (E/I) synaptic homeostasis using a human iPSC-based model.
Stimulus and circuit contributions to the information geometry of neural manifolds biorxiv.org 2026-06-25 Understanding how network connectivity shapes neural representations is central to systems neuroscience.
Neurodevelopment Trajectory of Electrophysiological Functional Connectivity Following Alcohol Use Initiation biorxiv.org 2026-06-25 Background: Adolescence is characterized by profound neurodevelopmental changes that shape large-scale brain network organization and may confer vulne
JNJ-42153605, a mGluR2 PAM, potentiates Levetiracetam treatments of TBI to mitigate subsequent tau aggregation in a larval zebrafish model biorxiv.org 2026-06-25 Traumatic brain injury (TBI) has long-term consequences that include chronic traumatic encephalopathy (CTE) and an elevated risk for Alzheimer Disease
Exploring the functionality of market-available tools for neural recording biorxiv.org 2026-06-25 Low-cost and open-source neural recording systems are increasingly important for expanding access to electrophysiological research.
Dysfunction of the colliculus-pulvinar pathway in children with developmental dyslexia biorxiv.org 2026-06-25 While evidence suggests magnocellular deficits in the geniculostriate pathway in adults with dyslexia, neural deficits in the subcortical pathways dur
Methamphetamine-induced disruption of neuropeptide expression in mice biorxiv.org 2026-06-25 Psychoactive and psychotoxic drugs are particularly harmful, if their use coincides with critical developmental windows of brain maturation.
Sexually dimorphic behavioural signatures of tau toxicity in adult Drosophila biorxiv.org 2026-06-25 Tau pathology is central to Alzheimers disease and related tauopathies, yet mechanisms driving neuronal dysfunction and degeneration downstream of pat
Btbd11 regulates glutamatergic synapse organization in GABAergic inhibitory interneurons biorxiv.org 2026-06-25 The mechanisms that underlie glutamatergic synapse organization and function in GABAergic inhibitory interneurons (INs) are not well described, despit
Medullary epithelium-free areas in the rat thymus are specialized niches enriched for mature thymocytes and distinct stromal subsets biorxiv.org 2026-06-25 The thymic medulla provides the microenvironment for negative selection, late thymocyte maturation, and thymocyte egress, and is generally characteriz