Specific killing of Ewing sarcoma by TCR-T cells targeting public neogene-encoded antigens biorxiv.org 2026-06-25 EWSR1::FLI1, the oncogenic chimeric transcription factor driving Ewing sarcoma (EwS) induces expression of exquisitely EwS-specific neogenes (Ew_NGs)
Continuous mark-release recapture to improve estimates of movement and survival of the African malaria mosquitoes biorxiv.org 2026-06-25 Despite extensive efforts to understand the population biology and ecology of the African malaria mosquitoes questions regarding their movement patter
Coral settlement module designs for scalable reef restoration biorxiv.org 2026-06-25 The global coral reef crisis has prompted restoration initiatives worldwide.
Emerging Beetle-Pathogen Symbioses and Their Consequences for Forest Health: Lessons from Rapid 'Ohi'a Death in Hawai'i biorxiv.org 2026-06-25 Invasive ambrosia beetles and fungal pathogens threaten forest ecosystems worldwide, exemplified in Hawai'i by the widespread loss of keystone species
PARP1 Exhibits an Enzymatically Inactive Chromatin Binding Mode biorxiv.org 2026-06-25 Poly (ADP-ribose) Polymerase 1 (PARP1) is an abundant nuclear enzyme that dynamically engages chromatin in diverse cellular scenarios.
Genetic Code Expansion, Enzymatic Modification, and C-Terminal Labeling Enable Facile Production of Highly Modified α-Synuclein biorxiv.org 2026-06-25 -Synuclein (S), a protein that plays a central role in Parkinson's disease and related synucleinopathies, is an intrinsically disordered protein (IDP)
Self-assembling nanoparticles to assess multivalent interactions between influenza A virus hemagglutinin and glycan surfaces biorxiv.org 2026-06-25 The multivalent display of surface glycoprotein hemagglutinin (HA) on Influenza A viruses (IAVs) enhances the overall binding avidity to sialylated gl
Tracing the Path from 4-Hydroxyphenylpyruvate to the Benzoquinone Ring of Q6 and the p-aminobenzoate pathway in Yeast biorxiv.org 2026-06-25 Coenzyme Q (ubiquinone, CoQ) is an essential component of the mitochondrial electron transport chain and a major lipid antioxidant in eukaryotic cells
High-Throughput Screening Identifies Small-Molecule Inhibitors of the Tau-LRP1 Interaction biorxiv.org 2026-06-25 The cellular uptake and propagation of tau are central features of tauopathies, including Alzheimers disease, and are mediated by the endocytic recept
Confocal Raman Microscopy-Guided Optimization of Early Otic Differentiation from Human Pluripotent Stem Cells biorxiv.org 2026-06-25 Generation of otic progenitors from pluripotent stem cells requires precise timed regulation of signalling pathways, including bone morphogenetic prot
Lipid Network Crosslinked Hydrogels: Controlling MaterialDynamics Across Multiple Length Scales Through Lipid Movement biorxiv.org 2026-06-25 Control over network dynamics at different length scales is a feature of natural materials challenging to replicate in synthetic hydrogels.
Mismatch repair dissection by in vivo RNAi reveals dose-dependent modulators of somatic instability and proteome remodeling in Huntingtons disease biorxiv.org 2026-06-25 Human and mouse genetics have established mismatch repair (MMR) as a central mediator of somatic repeat expansion, a key pathogenic process in Hunting
Antifungal resistance mechanisms and nosocomial transmission of Nakaseomyces glabratus: genomic investigation and observational study in Melbourne, Australia biorxiv.org 2026-06-25 Nakaseomyces glabratus (Candida glabrata) is a WHO high-priority fungal pathogen associated with fungal antimicrobial resistance (fAMR).
DextraDemixer enables accurate identification of antigen-specific T cells from pMHC multimer experiments biorxiv.org 2026-06-25 Antigen specificity of T cells defines the adaptive immune response, yet the vast majority of known T cell receptors (TCRs) lack annotated antigen tar
Do nanoplastics reshape microglial support of neuronal resilience? A study of microglial bioenergetics and microglia to neuron communication in vitro biorxiv.org 2026-06-25 Nanoplastics (NPs) are emerging environmental contaminants able to cross biological barriers, disrupt cellular and organelle homeostasis, and alter th
Identifying Novel Estrogenic Mitochondrial Targets in Hypothalamic Proopiomelanocortin Neurons by Chemoproteomics biorxiv.org 2026-06-25 Loss of estrogens at menopause is linked to impaired brain metabolism and increased risk of Alzheimers disease (AD).
Macroevolutionary consequences of twin neck innovations in deep-sea dragonfishes biorxiv.org 2026-06-25 The origin of novel phenotypes can influence access to new ecological resources, which may have positive, neutral, or negative effects on subsequent p
The crabeater seal reference genome reveals hallmarks of persistently large effective population size and sustained population expansion in the World's most abundant pinniped biorxiv.org 2026-06-25 Population genetic theory predicts that a species demographic history shapes patterns of genome-wide variation.
Tachykinin neuropeptides are involved in axonal and synaptic differentiation of the pioneer motor axon in zebrafish biorxiv.org 2026-06-25 In contrast to many other developing systems, in which axon pathfinding and synaptogenesis are separated in time, the pioneering axon of the individua
An extraglomerular relay circuit for multimodal integration within the Drosophila antennal lobe biorxiv.org 2026-06-25 The central integration of sensory information within and between brain hemispheres is critical for efficient behavioral responses, but at which level
Expanded protocadherin-1 usage reveals a broader hantavirus entry landscape biorxiv.org 2026-06-24 Mammalian hantaviruses are RNA viruses that cause hantavirus cardiopulmonary syndrome in the Americas and hemorrhagic fever with renal syndrome in Eur
Three Plasmid Strategies, One Intermediate Convergence State: Lineage-Specific Resistance, Virulence Architecture in Dominant Indian Carbapenem-Resistant Klebsiella pneumoniae Clones biorxiv.org 2026-06-24 Abstract Carbapenem-resistant Klebsiella pneumoniae (CRKp) is a critical global healthcare threat driven by high-risk multidrug-resistant (MDR) clones
Assessing Corynebacterium glutamicum as a surrogate of Mycobacterium tuberculosis for DNA gyrase inhibitor design. biorxiv.org 2026-06-24 DNA gyrase is an essential bacterial enzyme and a clinically validated target for the treatment of tuberculosis.
Comprehensive Profiling of Monkeypox Virus Antigens Identifies Potent Targets for Next-Generation mRNA Vaccine Development biorxiv.org 2026-06-24 The 2022 Monkeypox virus (MPXV) outbreak renewed interest in vaccines for orthopoxviruses.
Quantitative modeling of SARS-CoV-2 replication reveals phase-specific bottlenecks and antiviral targets biorxiv.org 2026-06-24 SARS-CoV-2 replication depends on a tightly coordinated series of intracellular processes that remain incompletely quantified.
Engineering nanoparticle surface chemistry for antigen-presenting cell targeting improves specificity and safety of TLR3 agonist cancer immunotherapy biorxiv.org 2026-06-25 Innate immune agonists are promising therapeutic agents to induce immune responses against cancer.
The "osteostat": a theory of bone mechanosensing and setpoint adaptation based on osteocytes biorxiv.org 2026-06-25 The osteocyte network in bone is believed to play an important role for how bone tissues sense and respond to mechanical stimulation.
Ergothioneine, alone or combined with vitamin K2, vitamin D3 and magnesium L-threonate, attenuates bone turnover, inflammatory and oxidative disturbances in ovariectomized mice biorxiv.org 2026-06-25 Purpose: Estrogen deficiency drives bone loss through a complex interplay of endocrine, oxidative, inflammatory, and bone-remodeling disturbances.
Assessing the influence of edge effects on macrofaunal contributions to decomposition rates across forest-field ecotones. biorxiv.org 2026-06-25 Understanding the relationships between soil macrofauna and decomposition is crucial for predicting how land-use change impacts ecosystem function in
Individual-level traits outweigh neighborhood and landscape level factors for frugivorous insect parasites in small forest patches biorxiv.org 2026-06-25 Frugivorous insect larvae are dependent on fruiting plants for development, leading to complex host-parasite interactions that may be influenced by ma