A Thin Film Transistor Backplane for Scalable Chronic Neural Interfaces biorxiv.org 2026-06-24 Scaling neural interfaces to ever-higher channel counts has accelerated rapidly with advances in thin-film fabrication, lithography, and connectorizat
Organizational principles governing synapse types in a whole-brain connectome biorxiv.org 2026-06-24 Neurons are classically viewed as polarized elements in which dendrites receive synaptic input and axons provide output.
Near-atomic structures of human astrovirus capsids reveal a subunit-specific maturation mechanism biorxiv.org 2026-06-23 Human astrovirus (HAstV) is a major cause of acute gastroenteritis, yet the structural basis of capsid maturation and infectivity remains poorly under
Spicing up urinary tract infections: synergistic action of fosfomycin with trans-cinnamaldehyde - insight to the mode of action biorxiv.org 2026-06-23 Objectives: Fosfomycin (FOS) remains an important therapeutic option for urinary tract infections caused by uropathogenic Escherichia coli (UPEC), but
Reversal effects of Isochlorogenic acid A on HBV-induced transcriptional dysregulation and apoptotic signaling biorxiv.org 2026-06-23 Chronic hepatitis B virus (HBV) infection contributes to hepatocellular carcinoma by disrupting host transcription, cell-cycle control, and apoptotic
Repair outcomes after germline homing endonuclease cleavage in Anopheles gambiae inform the design of synthetic gene drives biorxiv.org 2026-06-23 Homing endonuclease genes spread by cleaving homologous chromosomes that lack the endonuclease cassette, after which repair from the endonuclease-cont
A Scalable Framework for Species-Resolved Human Gut Microbiome Profiling Using Full-Length 16S rRNA Sequencing biorxiv.org 2026-06-23 The gut microbiota plays a fundamental role in human health, nutrition, immune development, and disease, driving widespread adoption of 16S rRNA gene
Surface-specific film assembly of a Vibrio cholerae adhesin peptide modulated by environmental salts biorxiv.org 2026-06-23 Underwater adhesion research increasingly draws on bioinspired systems to uncover the molecular mechanisms that enable strong interfacial binding in a
Directional information flow as a tool for analyzing protein allostery biorxiv.org 2026-06-23 The ability to tune protein function through the binding of modulatory ligands enables the development of therapeutics that steer a biological system
DNA-barcode labelled MHCII multimers for detection of antigen-specific CD4 T cells across large libraries of epitopes biorxiv.org 2026-06-23 The role of antigen-specific T cells responding to antigen is a topic of intense studies, and critical for mechanistic insight of diseases and develop
EndD mediates butyrate-dependent toxin release in Clostridioides difficile biorxiv.org 2026-06-23 Clostridioides difficile is an urgent threat to human health. Current treatments for C.
Malaria parasites coordinate host cell remodeling through the AP2-HCR DNA-binding protein biorxiv.org 2026-06-23 Parasite-induced host cell remodeling is essential for Plasmodium falciparum survival during the intraerythrocytic developmental cycle (IDC), yet the
Unraveling Xanthomonas acetyltransferase GumG: decoding catalytic promiscuity, understanding the mechanism, and enhancing enzymatic versatility biorxiv.org 2026-06-23 Xanthan is a structurally complex exopolysaccharide produced by Xanthomonas campestris and one of the most extensively studied microbial biopolymers.
Distinct taxonomic groups of sponge symbionts have the biosynthetic capacity for the production of ether lipids biorxiv.org 2026-06-23 The marine sponge holobiont, composed of the sponge host and its microbial symbionts, is a known source of abundant and diverse ether lipids (ELs).
Honey bee (Apis mellifera) gut microbiome associations with viruses and pesticides across Canadian agroecosystems biorxiv.org 2026-06-23 The honey bee (Apis mellifera) gut microbiome plays a central role in host health, yet its variation across agricultural landscapes remains poorly res
A new semi-automated, motility-based screening assay for discovery of compounds with activity against the juvenile stage of Fasciola hepatica biorxiv.org 2026-06-23 Fasciola hepatica is a trematode parasite responsible for fasciolosis, a liver disease that affects humans and livestock worldwide.
Microbiome histidine competition mediates dietary control of systemic imidazole propionate biorxiv.org 2026-06-23 The gut microbiome produces numerous metabolites that influence mammalian health.
Metabolically engineered oilcane reshapes rhizosphere microbial guilds while preserving broad functional capacity biorxiv.org 2026-06-23 Metabolic engineering of crops can redirect host carbon flux, but its consequences for microbiomes remain unclear.
Gut Microbiota Alterations and Probiotic Intervention in Asian Elephants (Elephas maximus) with Gastrointestinal Distress biorxiv.org 2026-06-23 Advances in metagenomic sequencing have transformed our understanding of host-;associated microbiota, revealing critical roles in immune regulation, n
Orally available designed miniproteins inhibit enterotoxigenic Bacteroides fragilis pathology by blocking toxin receptor binding biorxiv.org 2026-06-23 Toxigenic bacterial infections in the gut are a significant contributor to the global burden of disease.
A novel reverse lipase toxin substrate of the Staphylococcus aureus type VII secretion system biorxiv.org 2026-06-23 The type VII secretion system (T7SS) is found in many Gram-positive bacteria and secretes toxins with antibacterial activity.
Dynamic redistribution of eIF4F controls cap-dependent translation initiation biorxiv.org 2026-06-23 Translation initiation requires messenger RNAs (mRNAs) to be recognized and loaded into ribosomes through a process catalyzed by the heterotrimeric eu
Complementary Single-Cell Microflow HILIC and Ion Pair LC-MS Reveal Bystander Metabolic Effects in a Macrophage Model of Tuberculosis biorxiv.org 2026-06-23 Single cell metabolomics remains analytically challenging due to the low abundance and chemical diversity of metabolites in individual cells.
Minimizing methane emissions during the degradation of sewage sludge in a sulfate-rich bioreactor biorxiv.org 2026-06-23 Simultaneous removal of organic waste and industrial gypsum was assessed in continuous flow-through bioreactors that treat sulfate-rich sewage sludge.
Uncovering parasite diversity in Ecuadorian wildlife: new trypanosomatid species and novel reservoir hosts for Leishmania amazonensis biorxiv.org 2026-06-23 Wildlife hosts play important roles in the ecology and transmission of vector-borne parasites, yet information on host associations remains scarce in
predNMD: prediction of nonsense-mediated mRNA decay for improved clinical variant pathogenicity classification biorxiv.org 2026-06-23 The clinical consequence of a stop-gain variant depends on whether it ablates protein production by triggering nonsense-mediated mRNA decay (NMD) or y
Development and Analytical Validation of a Smartphone-Based Quantitative Lateral Flow Immunoassay for Serum Cystatin-C biorxiv.org 2026-06-23 Cystatin-C is an important renal function biomarker, and conventional quantification requires centralized laboratory analyzers, which limits timely te
FateLimit quantifies the prediction horizon of cell fate biorxiv.org 2026-06-23 Single-cell technologies have enabled increasingly detailed reconstruction of developmental trajectories, yet a fundamental question remains unresolve
A structure-derived contact-network responsiveness atlas of human proteins biorxiv.org 2026-06-23 Protein structures encode non-local contact organization, but static coordinates do not directly quantify how a contact network responds when effectiv
Adiposity in Adolescence has Detrimental Effects on Developing Brain Structures and Organization, Communication, and Controllability of Resting-State Networks biorxiv.org 2026-06-23 Adiposity in adolescence can have detrimental effects on neural maturation, and is associated with incompletely understood alterations in brain struct