Conserved T cell receptor usage underpins recognition of CD1c presenting a mycobacterial lipid biorxiv.org 2026-06-22 The mechanism by which T cell receptors (TCR) recognise mycobacterial lipids presented by CD1 family members not well understood.
Chitin oligomers induce atypical NLRP3 inflammasome activation and innate immune training biorxiv.org 2026-06-22 Chitin is a highly abundant poly- N-acetyl-glucosamine (GlcNAc) and linked to immune recognition of fungal infections and asthma in humans.
IL-38 limits alloreactivity through modulating myeloid and T cell activation biorxiv.org 2026-06-22 Interleukin-38 (IL-38) is a cytokine of the IL-1 cytokine family that promotes the resolution of inflammation.
Real-world results from a Machine Learning-guided, phenotypic High-Throughput Screen for novel antibiotics biorxiv.org 2026-06-22 Antimicrobial resistance is an urgent global health threat, with over 2.8 million multidrug-resistant infections killing over 35,000 annually in the U
A representative of a ubiquitous bacterial lineage parasitically feeds on host RNA biorxiv.org 2026-06-22 Cellular metabolism is widely understood as an integrated network of redox reactions, energy conservation, and biosynthetic pathways.
DNA cytosine methylation modulates UV resistance and nucleotide excision repair gene expression in Escherichia coli biorxiv.org 2026-06-22 Bacterial survival after ultraviolet (UV) exposure is shaped not only by the extent of DNA damage but also by the physiological state-dependent capaci
Active non-redundancy and viral orchestration sustain diel microbial successions in the coastal ocean biorxiv.org 2026-06-22 Ecosystem resilience in dynamic coastal oceans is conventionally ascribed to functional redundancy, where taxonomically distinct microbes buffer envir
The primate gut bacterial microbiome: a systematic review of research methodologies, taxonomic coverage, and conservation implications biorxiv.org 2026-06-22 Primates are central to both human evolutionary research and ecosystem functioning, serving as seed dispersers, predators, pollinators, and prey.
Organic availability and microbial competition for acetate suppress methane emissions during the conversion of gypsum in sewage sludge biorxiv.org 2026-06-22 Conventional anaerobic digestion emits methane from organic waste.
Efficient septum formation is essential for chromosome segregation in Bacillus subtilis when SMC function is impaired biorxiv.org 2026-06-22 Structural maintenance of chromosomes (SMC) complexes play conserved roles in chromosome organization, segregation, and repair in all domains of life.
Comparison of Four Density Gradient Centrifugation Protocols for Purification of Toxoplasma gondii PRU Brain Cysts biorxiv.org 2026-06-22 Toxoplasma gondii is an obligate intracellular zoonotic protozoan that establishes persistent brain cysts in infected hosts, causing chronic infection
Generalized Chargaff symmetry in codon usage across the tree of life biorxiv.org 2026-06-22 Codon usage bias is a central record of mutation, selection, drift, and translational constraints, but it is usually treated separately from generaliz
A recombinant dilp2GS-rpr donor line for adult-inducible IPC ablation across Drosophila genetic backgrounds biorxiv.org 2026-06-22 Genetic-background studies require defined perturbations that can be crossed reproducibly into many recipient backgrounds.
Neuroendocrine arylhydrocarbon receptor regulates gut microbiome of C. elegans via redox tone biorxiv.org 2026-06-22 The gut microbiome profoundly influences host health, with disrupted microbial communities implicated in inflammatory, metabolic, and neurological dis
Sex differences in PRDM9-independent fine-scale recombination patterns biorxiv.org 2026-06-22 Meiotic recombination rates exhibit strong, fine-scale variation along the genome of many eukaryotes.
Genetic introgression and transcriptomic plasticity are associated with enhanced Leishmania infantum pathogenicity causing human cutaneous leishmaniasis in Tunisia biorxiv.org 2026-06-22 The protozoan parasite Leishmania infantum exhibits significant genetic variability among isolates, influencing disease manifestation and treatment re
First outbreak of Lumpy Skin disease in Catalonia, Spain, 2025-2026 biorxiv.org 2026-06-22 Lumpy skin disease (LSD) is an emerging cattle disease caused by lumpy skin disease virus (LSDV), with major impacts on the industry, being classified
PanRes: A database of latent and acquired antimicrobial resistance allowing 3D-based protein homology search biorxiv.org 2026-06-22 Antimicrobial resistance databases are central to genomic surveillance, but resistance determinants remain distributed across resources with different
EMAlign: accurate alignment of cryo-EM maps through main-chain probability using deep learning biorxiv.org 2026-06-22 Accurate alignment of cryo-EM density maps is essential for comparing conformational states, searching map libraries, and guiding atomic model buildin
The Dilated Cardiomyopathy E525K β-Myosin Mutation Causes Hypocontractility in Cardiomyocytes Without Altering Crossbridge Cycling biorxiv.org 2026-06-22 The {beta}-cardiac myosin (MYH7) mutation E525K was first identified in 2012 in a patient with dilated cardiomyopathy (DCM).
Simulation of cell-size systems at long timescales with flexible protein structures biorxiv.org 2026-06-22 Protein behavior inside cells is dominated by the crowded nature of the intracellular environment.
Spatial Orchestration of Skin Fibrosis by a CD8+ T cell-Myofibroblast Axis biorxiv.org 2026-06-22 Fibrosing skin diseases are highly morbid conditions with diverse clinical and histopathologic features.
Label-free Pathogen Identification with Microscopy Imaging and Deep Learning biorxiv.org 2026-06-22 Rapid and accurate pathogen identification is crucial for the clinical management of infectious diseases, particularly sepsis and severe respiratory i
MALDI Tandem Mass Spectrometry for Colony-Based Dereplication of Natural Products biorxiv.org 2026-06-22 Microbial libraries remain an important resource for natural product discovery; however, constructing taxonomically and chemically diverse collections
Few-Shot Classification of C. elegans Developmental Stages via Explainable Hierarchical Hyperbolic Graph Embeddings biorxiv.org 2026-06-22 Automated, accurate, and fast developmental-stage classification of C.
Buzzing Frequency Influences Pollen Release in Buzz-Pollinated Poricidal Anthers biorxiv.org 2026-06-22 Buzz pollination is an important behavior in which bees use vibrations to extract pollen from poricidal anthers.
LTP-patterned electromagnetic stimulation induces NMDA receptor-dependent synaptic plasticity in cortical networks biorxiv.org 2026-06-22 Bioinspired electromagnetic stimulation, in which fields are patterned after endogenous neural activity, have emerged as a potential non-invasive appr
Targeting pathogenic VWF/ADAMTS13 dysregulation attenuates CTEPH progression biorxiv.org 2026-06-22 Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening pulmonary vascular disease, characterized by persistent thrombotic obstruc
A human intracranial map of consciousness returning from anesthesia biorxiv.org 2026-06-22 How consciousness arises from the brain remains a central yet unsolved question.
Encoding-related fMRI BOLD activity predicts subsequent memory for studied scenes, but not subsequent identification of perceptually similar lures. biorxiv.org 2026-06-22 Pattern separation is widely regarded as a hippocampally mediated process that reduces interference between memories of similar experiences.