Early rhizosphere assembly during the onset of photosynthesis reveals inoculum-constrained succession with increased phylogenetic clustering, filtering and diversity biorxiv.org 2026-06-26 The rhizosphere microbiome, one of the most diverse and metabolically active microbial ecosystems known, plays fundamental roles in plant health and p
Anaerobic conditions increase plasmid transfer rates across Escherichia coli strains biorxiv.org 2026-06-26 Bacterial conjugation is the primary mechanism by which antibiotic resistance genes spread in microbial populations, yet our understanding of this pro
OmrA sRNA Inhibits Translation of Phosphoenolpyruvate Carboxylase to Impair TCA-Cycle Flux biorxiv.org 2026-06-26 Small RNAs (sRNAs) rarely cause strong growth phenotypes upon overexpression, complicating efforts to link regulatory interactions to physiological ou
Bacterial Mercury Resistance Reveals a Robust Species-Structured Human Antimicrobial Mobilome biorxiv.org 2026-06-26 Antimicrobial resistance (AMR) is increasingly recognized as an ecological and evolutionary phenomenon that extends beyond clinical environments.
LRP1 is an entry receptor for the botulinum toxin complex in the gut biorxiv.org 2026-06-26 Botulinum neurotoxin (BoNT) is an etiologic agent of food poisoning caused by Clostridium botulinum.
PlantGeneAnn: a strand-specific genome foundation model for ab initio gene structure annotation of plant genomes biorxiv.org 2026-06-26 High-quality plant genome assemblies are rapidly increasing, but accurate structural annotation remains reliant on transcript and homology evidence, l
Coherent scene context accelerates and reshapes neural object representations biorxiv.org 2026-06-26 Coherent scenes facilitate object recognition, but the representational basis of this facilitation and its temporal evolution in the brain remain uncl
Scaling of Neuronal Growth and Excitability Through Separable mTORC1 and mTORC2 Pathways biorxiv.org 2026-06-26 As neurons grow, they must regulate intrinsic excitability to maintain an appropriate level of spiking based on synaptic inputs.
Mass-transfer-constrained thermodynamics links fluid motion to the preferential use of hydrogen and formate in syntrophic propionate oxidation biorxiv.org 2026-06-26 Syntrophic propionate oxidation in methanogenic environments depends on interspecies electron transfer through hydrogen and formate, yet the physical
Rapid assessment of nitrification inhibitor efficacy, competitiveness, and specificity using microrespirometry biorxiv.org 2026-06-26 Nitrification inhibitors are applied to reduce nitrogen losses and greenhouse gas emissions from fertilized agricultural ecosystems.
Structural basis of multimodal adsorption and infection initiation by Vibrio phage Peru-2 biorxiv.org 2026-06-26 Phage Peru-2, isolated during the 1993 cholera outbreaks in Peru, is distinct from the three ICP phage lineages typically associated with epidemic Vib
Consistent gut bacterial microbiota in European sea bass fed aquafeeds containing sustainable plant and invasive fish-based ingredients biorxiv.org 2026-06-26 The aim of this study was to evaluate the impact of two sustainable dietary protein sources on the structure and composition of the gut microbiota in
PhenoXtract: combining Large Language Model and Knowledge Graph embedding to extract phenotypes from clinical descriptions biorxiv.org 2026-06-26 Motivation: Standardized phenotypic descriptions are essential for accurate diagnosis, yet clinicians and researchers face challenges in manually extr
Coalescing nephron and ureteric bud progenitors potentiates nephrogenesis in recellularized kidney scaffolds biorxiv.org 2026-06-26 Bioengineered, transplantable kidney tissue using decellularized scaffolds offers a promising strategy to overcome the shortage of donor kidneys that
Consistent consensus-based annotation of spatial adaptive immune receptor repertoires from long-read sequencing using LongAIRR biorxiv.org 2026-06-26 The combination of spatial transcriptomics with long-read sequencing enables spatial characterization of full-length transcripts within solid tissue s
Robust neural face identity codes in the Super-Recogniser brain biorxiv.org 2026-06-26 Super-Recognisers show exceptional ability in face recognition, providing a natural model of how perceptual systems optimise for individuating visuall
Integrating genomic and tagging data reveals spatio-temporal population structure in Northeast Atlantic European sea bass biorxiv.org 2026-06-26 Understanding spatial and temporal connectivity among individuals with different migration strategies is essential for migratory ecology and effective
Molecular Basis of Mycoparasitic Performance: Genomic and Transcriptomic Comparison of Contrasting Trichoderma atroviride Strains biorxiv.org 2026-06-26 Trichoderma species are widely used as biological control agents due to their ability to parasitize plant pathogens.
Gene model for the ortholog of DENR in Drosophila eugracilis biorxiv.org 2026-06-26 Gene model for the ortholog of Density regulated protein (DENR) in the Apr.
Computational reconstruction of hierarchical cis-regulatory networks reveals synergistic transcription control and disease-associated rewiring biorxiv.org 2026-06-26 Gene regulation emerges from coordinated interactions among dispersed cis-regulatory elements, yet how these elements integrate into functional regula
A Generalised Epigenetic Clock Reveals Therapeutic Vulnerabilities Linked to Ageing in Cancer Cells biorxiv.org 2026-06-26 Epigenetic clocks estimate biological age from DNA methylation patterns but perform poorly in cancer due to extensive epigenetic reprogramming, limiti
Exogenous thymosin β4 enhances liver regeneration biorxiv.org 2026-06-26 Thymosin {beta}4 (T{beta}4) is a conserved acidic polypeptide with 43-amino acids participating in multiple pathophysiological processes.
Multi-Omics Clustering Differentiates the Total and Intact HIV Reservoirs and Related Host Immune Mechanisms biorxiv.org 2026-06-26 HIV reservoirs are heterogeneous across individuals, yet host determinants of this variability remain unclear.
Predatory bacteria impact C. elegans life-history traits by modulating microbiota community dynamics and thereby vitamin B12 availability biorxiv.org 2026-06-26 Predatory bacteria such as Bdellovibrio are emerging as ecological modulators in microbial communities by restructuring community composition, yet the
Vegetation change and functional composition shifts in southwestern China during late MIS 3 to LGM biorxiv.org 2026-06-26 The climatic transition from Marine Isotope Stage 3 (MIS3) to the Last Glacial Maximum (LGM) had caused widespread vegetation change.
Redefining accessible food resources for paleodietary reconstruction in Britain: baseline recommendations based on isotopic data synthesis biorxiv.org 2026-06-26 Paleodietary reconstruction requires isotopic data from both humans and their accessible food resources.
Pygopods are an exceptional radiation of snake-like geckos biorxiv.org 2026-06-26 Limb loss in vertebrate animals is surprisingly common despite imposing strong functional constraints.
Small-molecule inhibition of the Orientia tsutsugamushi deubiquitylating enzyme OtDUB impairs bacterial reproduction biorxiv.org 2026-06-26 Scrub typhus is a potentially fatal infectious disease caused by the obligate intracellular bacterium Orientia tsutsugamushi.
Hot Pursuit: Bioinformatic and Biochemical Characterization of a Hyperthermophilic Family B DNA Polymerase from Pyrolobus fumarii A1 biorxiv.org 2026-06-26 Thermostable DNA polymerases are indispensable tools in molecular biology, yet enzymes from the most extreme hyperthermophiles remain largely uncharac
BIRD-Seq: B2 Protein Integrated End-to-End Pipeline for dsRNA Detection and Nanopore Sequencing for Virus Monitoring biorxiv.org 2026-06-26 Double-stranded RNA (dsRNA) is a near-universal hallmark of active viral infection.