Preserved geometry during representational drift enables stable perception and memory biorxiv.org 2026-06-28 In many brain regions, the stimulus tuning of neurons is stable on a timescale of hours but not on a timescale of weeks, a phenomenon often called 're
The genetic signature of memory encoding along the human hippocampal axis biorxiv.org 2026-06-28 Episodic memory formation engages hippocampal oscillations that vary along the anterior-posterior axis, but the molecular programs supporting this phy
Brain Connectivity Modelling Through Joint Estimation of Parcels and Gradients biorxiv.org 2026-06-28 This paper presents a framework for modelling the topography of whole-brain connectivity in resting-state functional MRI.
The Importance of Synchrony in the Neural Control of Movement biorxiv.org 2026-06-28 Throughout the mammalian cortex, populations of neurons must work together to enact behaviors.
Sociality changes Gene Essentiality biorxiv.org 2026-06-28 Transposon insertion sequencing (Tn-seq) has become a powerful tool for assigning gene fitness and essentiality in bacteria, and has recently been ext
A cis-regulatory variant in ASIP causes gray coat color in the donkey biorxiv.org 2026-06-28 Background Gray is one of the relatively rare coat colors in donkeys.
Lineage-aware stochastic modeling reveals gene-expression dynamics in development and disease biorxiv.org 2026-06-28 Gene expression evolves dynamically along cell lineages, yet most analysis methods treat single-cell RNA-seq (scRNA-seq) data as static snapshots and
The genomic origins and evolutionary path to a key innovation in the world's most venomous snakes biorxiv.org 2026-06-28 Evolutionary innovation is a key driver of the colonization of new environments and the adaptive radiations of major groups.
Inference of fitness landscapes with heterogeneous patterns of epistasis across sites biorxiv.org 2026-06-28 Fitness landscapes provide a framework for understanding how genetic variation shapes evolutionary outcomes.
Processed pseudogenes as dynamic substrates of vertebrate genome evolution biorxiv.org 2026-06-28 Pseudogenes, gene copies presumed nonfunctional, are widespread products of genome evolution, yet their retention under selection and functional signi
Short-Read Sequencing Benchmarking with Donor-Specific Assemblies biorxiv.org 2026-06-28 Background High-throughput short-read sequencing has become a core technology for genomics, but the rapid expansion of available platforms has made it
LOESS and DE-SWAN can induce artifactual "waves" of molecular aging biorxiv.org 2026-06-28 A growing literature has investigated the relationship between age and biomolecular changes, leading to conclusions that aging occurs in discrete mole
Client-server interfaces enable efficient agent-driven variant calling biorxiv.org 2026-06-28 Background: Large language model (LLM) agents increasingly automate bioinformatics analyses, but most existing bioinformatics tools were built for sta
PARROT: Phase-Altering Regulatory Rewiring Over Time biorxiv.org 2026-06-28 Motivation: Gene regulatory networks undergo dynamic restructuring during development and disease.
Real Science Is Harder Than Benchmarks: Evaluating Advanced AI Frameworks on Published Studies. I. Uncertainty Quantification, ML on Therapeutic Data Commons, and Agent-Based Modeling biorxiv.org 2026-06-27 Artificial Intelligence (AI) frameworks for automating scientific research have shown strong performance on benchmarks, but their capacity to routinel
Ire1-triggered hxl1 mRNA splicing coordinates stress tolerance and virulence in the pathogenic fungus Trichosporon asahii biorxiv.org 2026-06-27 The pathogenic fungus Trichosporon asahii causes severe mycoses in immunocompromised hosts, such as neutropenic patients.
Isolation of bioconcrete-producing bacteria for urea-free marine applications biorxiv.org 2026-06-27 Manual intervention for concrete repair and replacement comes at high environmental and economic costs.
GpsB acts as an adapter for MacP-mediated activation of class A penicillin-binding protein aPBP2a in Streptococcus pneumoniae, independently of MacP phosphorylation biorxiv.org 2026-06-27 Regulation of class A penicillin-binding proteins (aPBPs) in peptidoglycan biosynthesis is incompletely understood in Gram-positive bacteria.
Inhibition of RNA splicing is a novel therapeutic strategy for disruption of nuclear replicating viruses biorxiv.org 2026-06-27 RNA splicing is a fundamental feature of eukaryotic gene expression that is co-opted by many nuclear-replicating viruses to produce viral transcripts.
Pulse-driven and persistent antimicrobial resistance markers in a transboundary Great Lakes connecting channel: pulse-week-stratified water-quality thresholds for One Health surveillance biorxiv.org 2026-06-27 Surface waters in urban watersheds receive episodic inputs of wastewater, runoff, and road-salt residues during spring, yet the contribution of these
Gram-negative-dominated polymicrobial microbiome of necrotizing soft tissue infections from North India: an integrated culture and 16S rRNA metagenomics prospective cohort study biorxiv.org 2026-06-27 Necrotizing soft tissue infections (NSTIs) carry 10 to 30% mortality.
Limited horizontal transmission of an obligate, free-living bacterial symbiont biorxiv.org 2026-06-27 Nutritional symbionts can be essential for their animal hosts.
West Nile virus response to mosquito and avian biodiversity in rural environments biorxiv.org 2026-06-27 Context.
Maintenance of viral diversity through influenza transmission bottlenecks: a within-host branching-process model biorxiv.org 2026-06-27 Viral populations can experience a dramatic reduction in population size and genetic diversity during transmission between donor and recipient hosts.
Comparing genomic inbreeding of an isolated rhesus macaque study population to wild populations biorxiv.org 2026-06-27 Long-term studies of isolated animal populations have greatly improved the understanding of various evolutionary processes.
Bacteriophage Heteroresistance as a Cause of Treatment Failure in Urinary Tract Infections biorxiv.org 2026-06-27 With the rise of antimicrobial resistance, urinary tract infections (UTIs) have become increasingly more difficult to treat, prompting renewed interes
Genetic Association of Somatic Incompatibility and NLR-like Protein Domains in Coprinopsis cinerea biorxiv.org 2026-06-27 In fungi, hyphal fusion is beneficial within an individual, but fusion between individuals comes with the risks of infection or exploitation.
Genomic insights into bacterial kidney disease resistance in Arctic charr (Salvelinus alpinus) via a 72k SNP array biorxiv.org 2026-06-27 Selection for disease resistance forms one of the most highlighted areas of aquaculture breeding.
Targeted epigenetic repression of oncogenic transcription factors via CRISPR/dCas9 locus-specific silencing biorxiv.org 2026-06-27 Despite the revolutionary impact of genome engineering tools in medicine, the safe and effective intracellular delivery of CRISPR remains a major obst
Cryo-electron microscopy structure of the bovine ephemeral fever virus RNA-nucleoprotein assembly biorxiv.org 2026-06-27 Bovine ephemeral fever virus (BEFV), a member of the Rhabdoviridae family, is an arthropod-borne pathogen that causes acute febrile disease in cattle.