A winding road to coexistence: Interdependence of niche and fitness differences in E. coli with targeted resource uptake gene deletions biorxiv.org 2026-06-29 Resource competition theory typically assumes static traits and continuous supply of resources.
Diverse root fungal endophytes mediate plant access to soil nutrients biorxiv.org 2026-06-29 Plant roots are broadly colonized by endophytic fungi with saprotrophic capabilities, but our understanding of whether they function in ways that are
Molecular mechanism of IF1- and IF2-driven translation initiation in bacteria biorxiv.org 2026-06-29 Bacterial translation initiation is a highly regulated process essential for accurate start codon selection and the assembly of an elongation-competen
Incorporating Surfaced-Induced Dissociation Mass Spectrometry Data into an AlphaFold-derived deep learning network improves protein structure prediction biorxiv.org 2026-06-29 Surface-Induced Dissociation native Mass Spectrometry (SID-nMS) is a tandem MS activation method that yields information on the connectivity and stoic
In Vivo Quantification of Histone Acetylation Turnover and Acetyl-CoA Sources Using 2H2O Metabolic Labeling and High-Resolution Mass Spectrometry. biorxiv.org 2026-06-29 Dysregulated histone acetylation links cellular metabolism to gene expression, but measuring its in vivo turnover remains technically challenging.
Visualizing immunoreceptor forces and their effects in vivo biorxiv.org 2026-06-29 Immunoreceptors experience forces that modulate their activities; however, demonstrating this in vivo has been limited by technical challenges.
SLEEP CHANGES WHAT MEMORIES BECOME:DELAYED REACTIVATION REVEALS LATENT EFFECTS OF POST-LEARNING SLEEP biorxiv.org 2026-06-29 Sleep is thought to promote memory consolidation through the offline reactivation and reorganization of newly acquired information.
Precision-Controlled Active Inference Accounts for Sensory Reweighting in Quiet Standing biorxiv.org 2026-06-29 Human quiet standing depends on the context-dependent reweighting of vestibular, proprioceptive, and visual information.
Glomerular Hyperfiltration, Charge Selectivity, and the Low-Dimensional Structure of Glomerular Transport biorxiv.org 2026-06-28 Background The relative contributions of molecular size, electrostatic charge, and filtration rate to glomerular transport remain controversial.
Rett syndrome lifespan extension in mice via AI-guided ADAR editing biorxiv.org 2026-06-28 Rett syndrome is a severe neurodevelopmental disorder primarily caused by mutations in the MECP2 gene.
Lipid-mediated regulation of pneumolysin balances vascular injury and bacterial containment during pneumococcal infection biorxiv.org 2026-06-28 Severe infection with Streptococcus (S.) pneumoniae is a leading cause of acute lung injury, multiorgan failure, and death despite appropriate antibio
Conservation rescued the Mauritius kestrel from extinction but not from genomic erosion biorxiv.org 2026-06-28 Conservation can prevent species extinction via demographic recovery, yet it remains debated whether this translates into genomic recovery and restore
A cryptic local genetic cluster in Northern France amid the European mosaic of flat oyster lineages revealed by integrating SNP array and whole-genome sequencing biorxiv.org 2026-06-28 The European flat oyster (Ostrea edulis), like numerous other oyster species, has been exploited for millennia and cultivated and translocated for cen
Fiber-TEnCATS reveals haplotype-specific chromatin accessibility and DNA methylation at human L1HS loci biorxiv.org 2026-06-28 Human-specific long interspersed nuclear element-1 (L1HS) is an active and autonomous retrotransposon in the human genome.
Fault-tolerant 3D reconstruction from 2D spatial proteomics sections biorxiv.org 2026-06-28 Reconstructing 3D molecular volumes from sparsely sampled 2D tissue sections is limited by per-section marker dropout and tissue loss.
Ptolemaea: consensus, comprehensive annotation of antiviral defence systems in bacterial genomes biorxiv.org 2026-06-28 Motivation: Bacteria carry a large repertoire of antiviral defence systems, our knowledge of which is expanding rapidly.
Desktop-Scale Hit-Point Discovery for Intrinsically Disordered α-Synuclein Using State-Space Compression and a Discrete Phase-Interference Search Operator biorxiv.org 2026-06-28 The accessible chemical space dwarfs any tractable screening budget, and most artificial intelligence drug discovery pipelines respond by docking and
Towards a Unified Exact Solution of Rearrangement Small Parsimony for Natural Genomes biorxiv.org 2026-06-28 Phylogenetic reconstruction is a fundamental problem in comparative genomics.
CarveMe-GutMicrobes: Automated Metabolic Model Reconstruction for Gut Microbial Species and Communities biorxiv.org 2026-06-28 Genome-scale metabolic models (GSMMs) are important aids towards system-level understanding of the metabolic physiology of the gut microbes and for ra
MassSpectrum Analyzer: An interactive platform for proteomic searching parameter refinement and peptide modification focused re-scoring biorxiv.org 2026-06-28 Peptide spectrum annotation is critical for the assignment of peptides and the localisation of modifications.
Dual Carbohydrate Recognition by the Chitinase-like Protein CHI3L1 Through Distinct Glycosaminoglycan and Chitin-Binding Interfaces biorxiv.org 2026-06-28 CHI3L1 (YKL-40) is a chitinase-like glycoprotein involved in immune regulation, tissue remodeling, and cancer, yet the molecular principles governing
Loop-Directed Cofactor Binding Enables Programmable Multico-factor Protein Design biorxiv.org 2026-06-28 The emergence of respiratory, photosynthetic, and assimilatory complexes in evolution required proteins capable of binding multiple catalytic and elec
Redox-modulated bacterial deubiquitinase ElaD: Target recognition and suppression of K63-linked polyubiquitin accumulation in yeast. biorxiv.org 2026-06-28 Bacterial deubiquitinases (DUBs) are important virulence effectors that manipulate host ubiquitin signaling during infection.
Peri-Locus Coeruleus Controls Endothelial Cell Heterogeneity in Enriched Environments via Region-Specific Norepinephrine Signaling biorxiv.org 2026-06-28 The brain acts as a central integrator that enables organisms to interpret environmental stimuli and coordinate adaptive responses across the body.
A novel wild-derived MHC-linked locus regulates host immunity to gammaherpesvirus infection biorxiv.org 2026-06-28 Inefficient host control of infection by gammaherpesviruses is a risk factor for lymphoproliferative disease, autoimmunity, and cancer, yet naturally
Stroke-induced lipocalin-2-expressing red pulp macrophages reprogram peripheral immunity biorxiv.org 2026-06-28 Acute ischemic stroke (AIS) induces profound systemic immune alterations that contribute to infection susceptibility.
Restriction-site-based enrichment coupled to adaptive sampling enables long-read transposon-insertion sequencing biorxiv.org 2026-06-28 Long-read Transposon insertion sequencing is essential for linking genotypes to phenotypes, as short- read approaches struggle with complex genomic re
Genetic architecture of the murine serum metabolome reveals carboxyl esterases as master regulators of circulating fatty acid metabolism biorxiv.org 2026-06-28 Background The systemic biochemical diversity of circulating metabolites and lipids reflects the integrated effects of genetic variation and environme
GR-SAFS: A Graph-Regularized Stacking Framework with Adaptive Feature Selection for High-Dimensional Prognostic Biomarker Discovery biorxiv.org 2026-06-28 Identifying prognostic biomarkers from high-dimensional transcriptomic data poses a triple challenge: achieving sparsity, preserving biological networ
High-fidelity rare structural variant detection with HiFiRE3 reduced representation via restriction enzyme ends biorxiv.org 2026-06-29 High-fidelity detection of rare structural variants (SVs) remains challenging because library preparation and sequencing techniques generate artifactu