Fragmented sleep during pregnancy induces inflammation and tryptophan-kynurenine pathway metabolism: Importance of elevated fetal brain kynurenic acid biorxiv.org 2026-06-29 Maternal sleep disturbance is an underrecognized risk factor for adverse offspring outcomes.
Transition of a Yeast Endosymbiont from a Free-living to Host-reliant Lifestyle Through Gene Loss and Horizontal Gene Transfer biorxiv.org 2026-06-29 Endosymbiosis is widespread throughout the tree of life.
Independent origins of fish endothermy converge on a developmental regulatory signature biorxiv.org 2026-06-29 Why independent origins of the same complex physiological trait repeatedly produce similar body forms and physiological changes remains central in evo
Comparative genomics of the unusual arachnid order Solifugae spotlight the molecular and genetic basis for adaptations to arid habitats biorxiv.org 2026-06-29 The evolutionary transition to terrestrial life required overcoming several physiological hurdles; however, such challenges were amplified in desert e
A Highly Contiguous Reference Genome for Scalesia gordilloi (Asteraceae), a Critically Endangered Plant Endemic to the Galapagos Islands biorxiv.org 2026-06-29 Scalesia gordilloi is a critically endangered species endemic to San Cristobal Island in the Galapagos archipelago and represents one of the most uniq
OpenGerminal: an open-source implementation of the Germinal antibody design pipeline biorxiv.org 2026-06-29 Germinal is a recently described computational pipeline for de novo antibody design that combines AlphaFold-Multimer hallucination with antibody langu
Learning sculpts microstructure in real time: evidence from dense temporal sampling of diffusion MRI biorxiv.org 2026-06-29 Learning induces rapid microstructural plasticity in the human brain, yet the precise temporal dynamics of these changes remain unclear.
Pep2Mol: 3D Molecule Generation Targeting Protein-Protein Interfaces with Diffusion Models biorxiv.org 2026-06-29 Protein-protein interactions (PPIs) are central to biological processes.
AnimalTA: A simple yet flexible tool for video tracking and manual corrections. biorxiv.org 2026-06-30 1. Video-tracking programs have now become an essential tool for researchers measuring animal behavior across biological fields.
Additive Effects of Sleep Loss, Psychological Distress and Physical Inactivity on Cognitive Failures in Young Adults biorxiv.org 2026-06-30 Young adults frequently report cognitive complaints often attributed to sleep loss alone.
High-throughput whole-brain scattering imaging resolves Amyloid plaques through clearing-assisted contrast modulation biorxiv.org 2026-06-29 Label-free scattering imaging is widely used in pathology because it enables sensitive tissue assessment without exogenous contrast agents.
Retention, not flux: endpoint confounding caps computational prediction of peptide skin penetration, with a delivery-aware reframing biorxiv.org 2026-06-29 Bioactive peptides are now central to cosmetic and dermatological actives, yet predicting whether a given sequence will reach its site of action in sk
Causally measuring aging and rejuvenation through transcriptomic damage biorxiv.org 2026-06-29 Aging is caused, fully in large part, by the progressive accumulation of damage, yet quantifying age-related damage across tissues and conditions rema
Cortico-muscular control of postural balance in older adults - effects of training on functional connectivity biorxiv.org 2026-06-29 Background.
Latitudinal effects on weight and age-dependent survival of red fox Vulpes vulpes biorxiv.org 2026-06-29 Age-dependent survival is central to understanding population dynamics and life-history evolution.
Integrated RNA sequencing reanalysis reveals reproducible matrix-immune signatures in idiopathic pulmonary fibrosis biorxiv.org 2026-06-29 In idiopathic pulmonary fibrosis (IPF), the lung is remodeled through coordinated epithelial, stromal, and immune-associated programs, but individual
Critical Scaling Laws and Universality Classes in Biomolecular Condensates biorxiv.org 2026-06-29 Biomolecular condensates are widespread cellular self-assembled structures with essential functions.
Revisiting Cucuruchu, a Late Pleistocene site on the Venezuelan Caribbean coast with megafauna and lithic association biorxiv.org 2026-06-29 The study of historical documents from the original excavation led by J. M.
A transcription factor-pair work in concert to regulate gene expression across the life cycle of the pinewood nematode, Bursaphelenchus xylophilus biorxiv.org 2026-06-29 The migratory endoparasitic pinewood nematode (PWN), Bursaphelenchus xylophilus, is the causal agent of pine wilt disease, causing significant economi
Within-electrode temporal envelope processing predicts multi-channel speech outcomes across cochlear implant pulse rates biorxiv.org 2026-06-29 Cochlear implants (CIs) restore hearing by stimulating auditory neurons to encode amplitude envelopes across frequency bands, providing essential cues
Functional neural signatures of navigation impairment in early Alzheimer's Disease biorxiv.org 2026-06-29 Spatial navigation is impaired early in Alzheimer's disease (AD), but the neural computations affected by AD pathology remain unclear.
Structural basis for GluA1 AMPA receptor regulation by PRRT1/SynDIG4 in LTP biorxiv.org 2026-06-29 AMPA receptor (AMPAR) signalling underlies long-term potentiation (LTP), a cellular mechanism for learning that selectively involves GluA1-type AMPARs
Effects of bromodomain and extraterminal domain protein inhibition in a mouse model of Niemann-Pick type C disease biorxiv.org 2026-06-29 Defects in lysosomal lipid handling provoke fatal disorders presenting neurovisceral symptoms with variable onset and life spans.
Maintenance DNA methylation is necessary for age-related alterations in regulatory T cell transcriptional and DNA methylation signatures biorxiv.org 2026-06-29 CD4+FOXP3+ regulatory T (Treg) cells maintain self-tolerance, restrain immune responses during inflammatory stimuli, and promote tissue function and r
Strategic coexistence theory for evolutionary games biorxiv.org 2026-06-29 Evolutionary game theory and ecological coexistence theory both seek to predict the outcome of competition between biological entities, be they strate
Haplotype-specific chromosome painting unveils recombination patterns in the holocentric species Rhynchospora breviuscula H.Pfeiff. biorxiv.org 2026-06-29 The genus Rhynchospora Vahl (beak-sedges) comprises approximately 381 accepted species with a worldwide distribution, all of which possess holocentric
Constrained body mass evolution and decoupled morphological rates in plesiosaurs biorxiv.org 2026-06-29 Body size, through its links to various physiological traits, has often been hypothesized to influence evolutionary rates.
Opposing immunomodulatory effects of the Alternaria mycotoxin tenuazonic acid in immune and intestinal epithelial cells biorxiv.org 2026-06-29 Tenuazonic acid (TeA) is one of the most frequently detected Alternaria mycotoxins in contaminated food.
Legacy Effects of Early β-Adrenergic Stimulation Program Adipose Plasticity and Confer Metabolic Resilience in Obesity biorxiv.org 2026-06-29 Pathologic white adipose tissue (WAT) remodeling, characterized by fibrosis, inflammation, and adipocyte dysfunction, is a hallmark and driver of meta
Resident myeloid-derived immune cells contribute to early lipopolysaccharide-induced cytokine secretion in mouse soleus muscle biorxiv.org 2026-06-29 Skeletal muscles secrete a variety of cytokines in response to inflammatory stimuli such as lipopolysaccharide (LPS); however, the contributions of re