Plasmodium berghei liver stages establish a damage-mimicking vacuole to hijack host ER membrane contact site machinery for lipid uptake biorxiv.org 2026-06-30 Plasmodium liver stage parasites undergo massive intracellular replication and therefore require extensive acquisition of host-derived lipids.
Micafungin exposure drives multidrug resistance in Clavispora lusitaniae biorxiv.org 2026-06-30 Fungal infections are an escalating global health concern, with rare Candida species posing an urgent threat due to emerging multidrug resistance.
Longitudinal analysis of vaccine-associated alterations in the faecal microbiota of layer chickens using a vaccination schedule representative of commercial practice biorxiv.org 2026-06-30 The gut microbiota is crucial for immune development and overall health in chickens.
Statistical learning of bacterial growth in combinatorially constructed environments biorxiv.org 2026-06-30 Optimizing growth conditions and culture media is a major goal in microbiology.
Epistasis between SARS-CoV-2 M and N Proteins Balances Particle Assembly and Immune Evasion biorxiv.org 2026-06-30 Since its emergence in the human population, SARS-CoV-2 has continuously evolved to evade immune responses and robustly establish global circulation.
Near-complete genomes for nine haplochromine cichlid fishes reveal a novel centromeric satellite structure organised around a pair of inverted elements biorxiv.org 2026-06-30 The haplochromine cichlid fishes of Lake Malawi form one of the most dramatic examples of recent rapid radiation in vertebrates.
A refined Saccharomyces cerevisiae reference transcriptome from Direct RNA Sequencing, with a reusable pipeline for UTR annotation updates biorxiv.org 2026-06-30 Untranslated regions (UTRs) flanking the coding sequence govern mRNA translation, localisation, stability, and decay, making accurate UTR boundaries e
The hand microbiome is sensitive to topical antibiotics and has varying sensitivity to liquid soaps biorxiv.org 2026-06-30 Hand eczema has been described as having an increased prevalence in persons with increased frequency of hand washing.
Oligella otitidis sp. nov., isolated from middle ear discharge of children with chronic suppurative otitis media biorxiv.org 2026-06-30 Oligella otitidis MSHR-50489EDL strain (ATCC: TSD462; DSMZ: DSM118617) is a new species of the genus Oligella that was isolated from a middle ear disc
CoalMiner: a coalescent model generator for fastsimcoal2 biorxiv.org 2026-06-30 Demographic inference using the Site Frequency Spectrum (SFS) is often constrained by the number and complexity of models tested.
Smooth Muscle Cell Cytoglobin is a Negative Regulator of Atherosclerotic Fibrous Cap Development biorxiv.org 2026-06-30 Rupture of the fibrous cap is the primary cause of clinical complications from atherosclerosis.
Context-Aware Evidence-Gated Plasticity for Multi-Goal Learning in Spiking Neural Networks biorxiv.org 2026-06-30 Background / Introduction: Biologically inspired spiking neural networks can model adaptive behavior, but learning multiple goals is difficult because
Hippocampal microcircuits constrain the generation of epileptiform activity biorxiv.org 2026-06-30 Epilepsy is largely characterized using macroscale measures of neural activity, such as electroencephalography, which are unable to resolve the underl
Spatial Recruitment Model for Motor Potentials Evoked By Transcranial Magnetic Stimulation (TMS) for In-Silico Testing and Tuning of Closed-Loop Procedures biorxiv.org 2026-06-30 The primary motor cortex has a prominent role in transcranial magnetic stimulation (TMS).
β-cell-specific Ahr expression is critical to high-fat diet-induced hyperinsulinemia biorxiv.org 2026-06-30 Objective: The aryl hydrocarbon receptor (AhR) pathway primarily mediates pollutant responses by activating xenobiotic metabolism enzymes like cytochr
Intravital imaging of age-related conjunctival lymphatic changes on the ocular surface biorxiv.org 2026-06-30 Purpose: Lymphatic system plays a critical role in fluid regulation and immune response.
Sequencing, Chromosome-scale Assembly, and Annotation of the Genome of the Halophilic Nanoflagellate Halocafeteria seosinensis biorxiv.org 2026-06-30 Compared with bacterial and archaeal extremophiles, single-celled eukaryotes living in extreme habitats are understudied and underrepresented in genom
Computational Design of Two Novel BRAF V600E Inhibitors: Exploiting Sulfoximine Bioisosterism and Chiral Constraints to Evade Paradoxical Activation biorxiv.org 2026-06-30 Metastatic melanoma is an aggressive cutaneous malignancy frequently driven by the oncogenic V600E mutation within the BRAF kinase.
Diel metabolic variation and the energetic demands of courtship in bioluminescent Photeros ostracods biorxiv.org 2026-06-30 The energetic demands of courtship are central to sexual selection, but their magnitude and temporal variation remain poorly quantified in many signal
STING restrains calcium-dependent microglial phagocytosis and protects against neuronal loss and cognitive impairment during epileptogenesis biorxiv.org 2026-06-30 Epileptogenesis is accompanied by robust neuroinflammation, yet the molecular pathways linking innate immune activation to neuronal dysfunction remain
A Two-Fluid Model of Brain Dynamics biorxiv.org 2026-06-30 We develop a theoretical proposal linking vacuum stability and brain dynamics through superconductivity-inspired coherence, symmetry reduction, and th
Immune responses to infection modulate peripheral sympathetic neuron functions biorxiv.org 2026-06-30 The central nervous system interprets inflammatory signals in the body and directs the modulation of inflammatory responses by reflexively engaging pe
Smooth move: Behavioural changes in captive western lowland gorillas (Gorilla gorilla gorilla) after group split and relocation biorxiv.org 2026-06-30 Zoological gardens strive to prioritize excellent animal care and adhere to the highest standards of animal welfare, ensuring that the conditions of a
From innovation to integration: Personality, sex, and learning drive recombination of innovative behaviours in lovebirds biorxiv.org 2026-06-30 Behaviour innovation plays a pivotal role in a species' adaptability to dynamic environments.
Effects of aging on multiple object tracking under normal and altered viewing conditions biorxiv.org 2026-06-30 Multiple object tracking (MOT) is a core function of dynamic visual attention that relies on the ability to simultaneously monitor several moving obje
DNA: A Nanoscale Archimedes Screw biorxiv.org 2026-06-30 Rotating helices have been utilized for many purposes, including the transport of solid material and fluids within man-made machines, for a little ove
Homologous recombination deficiency prediction from whole slide images using label refinement and foundation-model benchmarking in ovarian cancer biorxiv.org 2026-06-30 Background: Homologous recombination deficiency (HRD) is clinically imperative in high-grade serous ovarian carcinoma (HGSOC), particularly because of
Basal Internalization and Subcellular Localization of XCR1 biorxiv.org 2026-06-30 Chemokines orchestrate immune cell trafficking through receptor-mediated signaling and are implicated in inflammatory, autoimmune, and neuropathic dis
Dietary protein source dictates the impact of obesogenic diets on hepatic steatosis and insulin resistance via carnitine-dependent regulation of acetyl-CoA carboxylase biorxiv.org 2026-06-30 Nutritional strategies to mitigate obesity and type 2 diabetes (T2D) have largely focused on dietary fat and carbohydrate composition, with less atten
MicroRNA regulation of stress-survival signalling and protein quality control in human heatstroke biorxiv.org 2026-06-30 Heatstroke is a life-threatening condition in which heat-shock and unfolded-protein responses are strongly activated but fail to prevent proteostasis