Direct probabilistic quantification of mosaic loss of chromosome Y from sequencing data biorxiv.org 2026-07-01 Loss of chromosome Y (LOY) is the most common aneuploidy in aging men and is increasingly recognized as a marker of aging and genomic instability.
MCD Stitcher: An open-source tool for whole-slide stitching and conversion of Imaging Mass Cytometry data biorxiv.org 2026-07-01 Imaging Mass Cytometry (IMC) combines metal-tagged antibody labelling with laser ablation mass spectrometry to generate highly multiplexed spatial ima
CryoGO enables high-resolution structural profiling of endogenous cellular macromolecules biorxiv.org 2026-07-01 Resolving macromolecular structures within their native cellular environment is essential for connecting molecular architecture to physiological funct
Molecular Basis of Core Fucosylation-Dependent Modulation of IgG1-FcCD16a Binding biorxiv.org 2026-07-01 Core fucosylation of the IgG1 Fc N297 glycan is known to reduce binding affinity to the FcYRIIIa (CD16a) receptor and attenuate antibody-dependent cel
A CSF Proteomic Clock Reveals Opposing Brain-Aging Programs and Predicts Neurological Disease Progression biorxiv.org 2026-07-01 Aging is a major risk factor for neurological disease, yet the molecular architecture of human brain aging remains poorly defined.
Machine learning on magnetoencephalography data yields generalizable low-dimensional neural fingerprints that distinguish individuals across task conditions biorxiv.org 2026-07-01 Individual brains are unique in structure and function.
Enhanced environmental complexity worsens experimental colitis and dysregulates microbiota-gut-brain axis signalling in female mice biorxiv.org 2026-07-01 Ulcerative colitis (UC) is a chronic inflammatory disease characterized by colonic inflammation and bloody diarrhoea.
Structural determinants of dynamical state transitions in disorders of consciousness: a whole-brain modeling approach biorxiv.org 2026-07-01 Disorders of consciousness (DoC) are associated with large scale alterations in brain dynamics, yet the structural factors that constrain these change
Multi-compartment immune and tumor cell reprogramming by IFNa2 overcomes colon cancer immunotherapy resistance biorxiv.org 2026-07-01 Tumor cell PD-L1 represses IFN signaling to limit anti-tumor immunity, despite an IFN-responsive immunophenotype predicting colorectal cancer response
ARL15 promotes inflammatory fibroblast activation and disease severity in rheumatoid arthritis: integrated transcriptomic and collagen-induced arthritis model analyses biorxiv.org 2026-07-01 Background ADP-ribosylation factor-like protein 15 (ARL15) is a rheumatoid arthritis (RA) susceptibility gene identified through GWAS.
Viral capsid delivery of cGAMP enhances STING-dependent antitumor immune response biorxiv.org 2026-07-01 Therapies to activate the STING immune response pathway represent promising potential anticancer treatments.
CD56dimCD16dim NK cells are the dominant effector cells against HIV-infected primary T-cells biorxiv.org 2026-07-01 Despite being rare among circulating natural killer (NK) cells and expressing 10-fold less CD16 than the predominant CD56dimCD16bright population, CD5
Nitrogen use efficiency in pigs is associated with transcriptomic signatures related to amino acid metabolism, immune activity, and nutrient partitioning biorxiv.org 2026-07-01 Dietary protein restriction challenges the allocation of amino acids to growth and other physiological functions and therefore requires coordinated me
Deciphering the nucleotide driven kinetic and oligomeric dynamics in IMPDH regulation biorxiv.org 2026-07-01 Inosine monophosphate dehydrogenase (IMPDH) controls guanine nucleotide biosynthesis.
DESI-MS-Based Analysis of Drug Distribution in Human Renal Cystic Tissue Using the Chorioallantoic Membrane (CAM) as a 3D In Vivo Model biorxiv.org 2026-07-01 The chorioallantoic membrane (CAM) model represents a promising three-dimensional in vivo platform for preclinical drug testing in human tissues.
Dietary Sodium Deprivation Remodels the Serum Lipidome and Reveals Systemic Metabolic Adaptation in Rats biorxiv.org 2026-07-01 Background: Dietary sodium restriction is a common nutritional and physiological challenge that activates electrolyte-conserving endocrine pathways, b
Tracking claim changes from preprint to publication across 72,644 biomedical studies using large language models biorxiv.org 2026-07-01 Preprints now disseminate a large share of biomedical research before peer review.
Headbutting goats self-inflict traumatic brain injury biorxiv.org 2026-07-01 Traumatic brain injury (TBI) is a characteristic feature of neurodegenerative diseases such as Alzheimers disease and chronic traumatic encephalopathy
Sequential infection reprograms the immune landscape to shape future responses biorxiv.org 2026-07-01 Mouse models have been instrumental in defining immune mechanisms but often fail to capture the complexity of human immunity, limiting clinical transl
Disruption of a CCR5-like immunoglobulin gene is linked to plague susceptibility in black-footed ferrets biorxiv.org 2026-07-01 Black-footed ferrets (Mustela nigripes) are highly susceptible to sylvatic plague caused by Yersinia pestis, but the genetic basis of this vulnerabili
Mitochondrial STAT3-mediated suppression of apoptosis constrains antimycobacterial immunity biorxiv.org 2026-07-01 Maintenance of mitochondrial homeostasis is required to balance the host-pathogen interface during Mycobacterium tuberculosis (Mtb) infection.
Technical Note: Focused ultrasound-mediated blood-brain barrier opening for delivery of LNP-packaged modRNA therapy in a mouse model of Niemann-Pick Disease Type C biorxiv.org 2026-07-01 Efficient delivery of molecular therapies to the central nervous system (CNS) remains a major barrier to treating neurogenetic disorders such as Niema
Ang2 and TAT targeting of leptomeningeal disease by the intravenous and intrathecal routes: a comparative analysis biorxiv.org 2026-07-01 Leptomeningeal disease (LD), involving the metastasis of cells to the leptomeningeal membranes in the central nervous system (CNS), can be a deadly co
Solvent-free Nanoparticle Assembly Protocol (SNAP): one-pot formulation of drug loaded polyester nanoparticles and their vessel size-dependent perivascular transport biorxiv.org 2026-07-01 This work describes a new approach for rapid and reproducible formulation of drug loaded biodegradable nanoparticles based on polyester copolymers, in
Dynamically actuated reconfigurable topographical surface enables active control of implant-associated infections biorxiv.org 2026-07-01 Implant-associated infections are driven by bacterial biofilm formation and remain difficult to eradicate using conventional antibiotic-based strategi
Spores-on-a-Chip: a new sample-loading strategy for multiplexed single-cell monitoring of spore germination within a microfluidic platform biorxiv.org 2026-07-01 We demonstrate a new sample-loading strategy ('spot-loading') for Spores-on-a-Chip microfluidic sensors that enables multiplexed experimentation.
Dodecagon light-sheet fluorescence microscopy for large-volume imaging without striping artifacts biorxiv.org 2026-07-01 Light-sheet fluorescence microscopy (LSFM) has revolutionized biological imaging by enabling high spatial and temporal resolution with minimal photoda
A dermal-epidermal junction-inclusive skin model enabled by controllable hydrogel swelling biorxiv.org 2026-07-01 Tissue engineered skin models are important tools for the in vitro study of physiological and pathophysiological processes as well as the valuation of
An engineered IdeS variant with enhanced activity and performance for IgG degradation biorxiv.org 2026-07-01 IgG-degrading enzymes have emerged as innovative therapeutic agents for treating conditions driven by pathogenic antibodies.
Penumbria: Advanced 3D cell segmentation for biomedical imaging biorxiv.org 2026-07-01 Quantitative analysis of three-dimensional cellular architecture is fundamental to understanding tissue organization, disease progression, and drug re