Retinal resuscitation in post-mortem eyes biorxiv.org 2026-06-30 Vision loss compromises the quality of life of millions of people worldwide. Currently, vision-restoring therapies are lacking.
Mitochondrial Hsp60/10 Client Protein Decline Reveals Braak/Tau- and Cognition-Linked Proteostasis Vulnerabilities in Alzheimer's Disease biorxiv.org 2026-06-30 Alzheimer's disease (AD) is classically defined by amyloid and tau pathology and is accompanied by broad disruptions in proteostasis.
Polytraumatic SCI worsens maladaptive plasticity in spinal motor systems biorxiv.org 2026-06-30 Spinal cord injury (SCI) results in dysfunction of both motor and sensory systems, which can be characterized by neuropathic pain, hypersensitivity, m
Berberine improves motor deficits in the spastic paraplegia SPG7 mutant mice biorxiv.org 2026-06-30 Hereditary spastic paraplegia type 7 (SPG7) is a neurodegenerative disorder characterized by progressive motor impairment and cerebellar dysfunction.
Aberrant neuronal differentiation and splicing defects in Congenital Myotonic Dystrophy (DM1) iPSC models biorxiv.org 2026-06-30 Myotonic Dystrophy type 1 (DM1) is an autosomal multisystem disorder manifested due to unstable CTG nucleotide repeat expansion within the 3'-untransl
APP-CTFβ/C99 oligomers drive synaptic vesicle tethering through C-terminal interactions biorxiv.org 2026-06-30 Proteolytic processing of the amyloid precursor protein (APP) generates a 99-amino acid precursor, {beta}-carboxyl-terminal fragments (APP-CTF{beta} o
Perceptual training selectively strengthens top-down signaling to sensory cortex biorxiv.org 2026-06-30 Sensory cortical neurons adjust their responses to enhance the detection and discrimination of behaviorally relevant stimuli.
Spinal injury induces a stem cell-like progenitor state that promotes regenerative neurogenesis via clcf1 in zebrafish. biorxiv.org 2026-06-30 After spinal injury, zebrafish, in contrast to mammals, show regenerative neurogenesis, characterized by enhanced injury-induced proliferation of epen
Recent history attracts and repels perceptual decisions depending on surprise biorxiv.org 2026-06-30 Past sensory experience shapes our perceptual decision-making in the now.
Diverse origins and transcriptional profiles of macrophages in a spinal lesion in zebrafish biorxiv.org 2026-06-30 The injury responses of tissue-resident macrophages in the CNS (microglia) and blood-derived macrophages (BDMs) play key roles in successful regenerat
Unintentional finger force drifts are minimally influenced by temporal evolution of surface friction biorxiv.org 2026-06-30 Humans consistently decrease the amount of force they produce during isometric finger pressing in the absence of visual feedback, a phenomenon often c
Single-Cell Transcriptomic Analysis of the Immune Response to CHIKVInfection biorxiv.org 2026-06-30 Abstract Background: The Chikungunya virus (CHIKV), a re-emerging mosquito-borne alphavirus, is responsible for acute febrile illness and severe polya
IgG4⁺ plasma cell enrichment and {lambda}-chain-biased BCR remodeling drive low-grade autoimmunity in chronic obstructive pulmonary disease biorxiv.org 2026-06-30 Background: This study aimed to elucidate B cell subset pathology in COPD, a poorly characterized area, with a focus on its similarities to and differ
Abundance, diversity and activity of endogenous retroviruses in the slow loris. biorxiv.org 2026-06-30 Endogenous retroviruses (ERVs) constitute a significant fraction of vertebrate genomes and serve as genomic records of past retroviral infections, whi
A High-Quality Acetylation Dataset Reveals Modest Data Requirements for Transfer Learning to Identify Little Studied Post-Translational Modifications biorxiv.org 2026-06-30 Dysregulation of post-translational modifications (PTMs) is associated with severe pathologies, including cancers and Alzheimer's disease.
Real-World Progression-Free Survival with Erlotinib versus Osimertinib in EGFR L858R+T790M Compound Mutation Non-Small Cell Lung Cancer: An Exploratory Analysis of the MSK-CHORD Dataset biorxiv.org 2026-06-30 Background: Osimertinib is the standard first-line treatment for EGFR- mutant non-small cell lung cancer (NSCLC) harboring common activating mutations
A robot model of compass cue calibration in the insect brain biorxiv.org 2026-06-30 Dung beetles can use a variety of orientation cues to maintain a consistent bearing during ball-rolling.
Who's driving? Common evolutionary mechanism of activation of class A GPCRs biorxiv.org 2026-06-30 Cells communicate with their environment by integrating signals, often chemical in nature, triggered by specific molecules bind to specific membrane-b
Proteomic profiling of xenobiotic and nutrient transporters in human placenta of different gestational ages biorxiv.org 2026-06-30 Background The placenta serves a critical role in nutrient uptake and waste elimination for the developing fetus.
Reduced Somatosensory Oscillatory Dynamics and Inhibition in Moderate-to-Severe Nociceptive Pain biorxiv.org 2026-06-30 Nociceptive pain is the most common pain condition, and moderate-to-severe nociceptive pain substantially impacts daily functioning, constituting a si
Microscopic Motor Alterations in Psychosis and Chronic Cannabis Use biorxiv.org 2026-06-30 Background and Hypothesis. Motor alterations represent an important component of psychotic disorders.
DATRASextra: An R package for streamlined workflows with ICES DATRAS bottom-trawl survey data biorxiv.org 2026-06-30 Scientific bottom-trawl surveys provide essential fisheries-independent data for fisheries and ecosystem research.
Form I and II Rubiscos Exhibit Temperature Dependent Carbon Kinetic Isotope Effects biorxiv.org 2026-06-30 Nearly all carbon on Earth today is fixed by the enzyme ribulose-1,5-bisphopshate carboxylase/oxygenase ('rubisco'), which converts carbon dioxide (CO
Ontological Analysis of Brain Proteostasis Highlights the Sex-Dependent Trajectory of ApoE Isoform-Specific Regulation biorxiv.org 2026-06-30 Apolipoprotein E (ApoE) is the strongest genetic predictor of Alzheimers disease (AD) risk, with ApoE4 increasing and ApoE2 decreasing risk relative t
Evaluating Approaches for Inference Testing of Whole-Brain Densely Sampled Single-Subject Task fMRI Data biorxiv.org 2026-06-30 Task-based precision mapping has become a promising technique in functional MRI (fMRI) to robustly characterize and map an individual's unique activit
A Selective Multivalent NET-Associated Chromatin Neutralizer Resolves Infection-Associated Inflammation in Severe Sepsis biorxiv.org 2026-06-30 Targeting the overwhelming inflammation driven by neutrophil extracellular traps (NETs) during infection provides an opportunity to manage severe seps
Computational Fluid Particle Dynamics (CFPD)-Based Virtual Next Generation Impactor (vNGI) to Predict the Aerodynamic Particle Size Distribution (APSD) of Respiratory Drug Delivery Products: Toward New Approach Methodologies (NAMs) in Inhaler Performance biorxiv.org 2026-06-30 The Next Generation Impactor (NGI) is one of the regulatory gold standards for characterizing aerodynamic particle size distributions (APSDs) of orall
From field naturalism to Bayesian models: fog-frost interaction shapes growth form partitioning along Himalayan gradient biorxiv.org 2026-06-30 Mountain gradients facilitate our understanding of species' range limits, competition dynamics, stress-resilience trade-offs, and determinants of vege
Latitude, not geography, globally structures Oscheius tipulae into three deeply divergent lineages biorxiv.org 2026-06-30 Free-living nematodes are among the most abundant animals on Earth and play critical ecological roles in soil ecosystems.
GeneBench-Pro: Evaluating Multistage Statistical Reasoning\\in Genomics, Quantitative Biology, and Translational Biomedicine biorxiv.org 2026-06-30 We introduce GeneBench-Pro, an expanded and improved version of GeneBench that comprises harder problems across a wider breadth of domains.