IP3R-TRPM4 Coupling Determines the Spatial Reach of Pericyte-Mediated Capillary Constriction biorxiv.org 2026-06-29 Ensheathing pericytes extend multiple projections that wrap around capillary vessels to regulate diameter and direct blood flow distribution across th
Inherent Biomechanical Properties of the Lung: In vivo-Ex vivo Comparisons in Mice biorxiv.org 2026-06-29 Mammalian lungs operate within a thoracic cage composed of parietal pleura, rib cage, skeletal muscle, and diaphragm, yet clinical ventilator metrics
Striatal dopamine signals internal states related to behavioral performance over prolonged timescales in monkeys biorxiv.org 2026-06-29 Slowly varying internal states govern our ability to sustain goal-directed behavior over minutes to hours, imposing fundamental constraints on cogniti
Viral infection drives cell-intrinsic re-localization of the C. elegans immune-repressive STAT transcription factor STA-1 biorxiv.org 2026-06-29 Detection of viral infection leads to both cell-intrinsic and cell-extrinsic responses.
B-cell SIGLEC-5 engages T-cell components of the elastin receptor complex (ERC) to suppress inflammatory T-cell cytokines biorxiv.org 2026-06-29 SIGLECs remain poorly defined in human B-cell biology beyond SIGLEC-2/CD22 and SIGLEC-10.
Host transcriptional programs underlying lesion development in contagious bovine pleuropneumonia biorxiv.org 2026-06-29 Contagious bovine pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp.
The contribution of recent and historical demographic histories to genomic diversity and conservation status in plant species biorxiv.org 2026-06-29 Demographic factors are intrinsically crucial to evaluate species' extinction risk.
Hydrophobic mismatch induces lipid sorting based on tail unsaturation biorxiv.org 2026-06-29 Biological membranes contain a diverse set of membrane proteins surrounded by many different lipids, and the lateral organization and function of thes
RNA-Encoded PGT121-LS Anti-HIV Antibody: Comprehensive Preclinical Characterization and Translational Pharmacokinetics biorxiv.org 2026-06-29 Human Immunodeficiency Virus (HIV)-1 broadly neutralizing antibodies (bNAbs) have demonstrated clinical efficacy, but face manufacturing challenges as
Droplet single-cell CRISPR screens identify regulators of T cell-mediated target-cell killing biorxiv.org 2026-06-29 Cytotoxic CD8 T cells kill target cells through brief cell-cell encounters, but pooled genetic screens cannot readily link perturbations in individual
A substrate recursion principle for biological information, with empirical anchoring through a templating-mode taxonomy biorxiv.org 2026-06-29 Biological inheritance can be treated as a class of catalytic templating reactions in which a daughter molecule, generated by a kinetic kernel acting
Fructooligosaccharide Supplementation Improves Glucose Homeostasis in Human-Relevant hyperglycemic Diet-Induced Obese Mice biorxiv.org 2026-06-29 Fructooligosaccharides (FOS) are prebiotic fibers that influence gut microbiota and host metabolic function.
Neprilysin mediated cleavage of phospholamban dysregulates SERCA in heart failure biorxiv.org 2026-06-29 Background Neprilysin (NEP) is a zinc-dependent metalloprotease targeted in heart failure therapy to prevent it degrading circulating cardioprotective
Leptin alleviates obesity hypoventilation via serotonergic pathways biorxiv.org 2026-06-29 Rationale. There is no effective pharmacotherapy for obesity hypoventilation syndrome (OHS).
Apparent Anatomical Variability Through Rigid Augmentation Enables Reliable Corpus Callosum Segmentation biorxiv.org 2026-06-29 The corpus callosum is a major white matter bundle responsible for connecting both hemispheres.
Compensation of the effects of temperature on a motor system in the crab, Cancer borealis biorxiv.org 2026-06-29 Rising ocean temperatures challenge ectothermic animals to maintain essential behaviors such as movement and feeding.
Much stronger coarse-to-fine visual processing in primate superior colliculus than primary visual cortex neurons biorxiv.org 2026-06-29 The visual system optimizes its signal processing properties to efficiently encode natural scenes.
MECP2-mutant marmosets exhibit primate-specific phenotypes of Rett syndrome biorxiv.org 2026-06-29 We used genome editing to generate MECP2-knockout marmosets and establish a new primate model for Rett syndrome (RTT), a neurodevelopmental disorder.
Paralogous lncRNAs CYTOR and MORRBID share a conserved trans acting function in MEK ERK signaling biorxiv.org 2026-06-29 Background: Long non-coding RNAs (lncRNAs) exhibit rapid evolutionary turnover, often driven by genomic duplication.
Conserved transcriptomic heat stress response signatures in coral recruits selectively bred from thermally distinct broodstock in a low-differentiation system biorxiv.org 2026-06-29 Thermal history provenancing can guide the choice of parental broodstock for selective breeding of corals from distinct reefs and has been proposed as
Assembly of a high-quality reference genome for the rat tapeworm Hymenolepis diminuta biorxiv.org 2026-06-29 The rat tapeworm, Hymenolepis diminuta, is an important laboratory model for uncovering molecular processes that underly the success of tapeworms as p
Healthy-to-Stroke Translation of EEG-Based BMIs: EEG Characterization and Reinforcement Learning-Based Decoder Evaluation biorxiv.org 2026-06-29 Purpose: EEG-based brain-machine interfaces (BMIs) may support assistive technologies for individuals with stroke-related motor impairment by translat
Metrics for Distinguishing Biological and Interventional Change in AI Models biorxiv.org 2026-06-29 Statistical and machine-learning models of longitudinal biological data evaluate change by comparing each new observation against the trajectory impli
Crossmodal Expectations in Material Perception biorxiv.org 2026-06-29 Humans rely on multiple sensory modalities, such as vision, audition, and touch, to perceive materials in everyday life.
Inverse reinforcement learning reveals action-oriented value signals in naturalistic decision making biorxiv.org 2026-06-29 A major challenge for cognitive neuroscience is to explain how value of a goal-directed behavior is computed in complex and naturalistic environments.
Dynamic Modulation of Distractor Suppression by Tonic and Trial-Level Alertness Fluctuations: A Pupillometric Study biorxiv.org 2026-06-29 Attentional control balances proactive suppression of predictable distractors with reactive suppression of unexpected ones.
Disruption of CaMKII biomolecular condensation induces attention-deficit/hyperactivity disorder-like phenotypes biorxiv.org 2026-06-29 CaMKII is a multifunctional kinase essential for synaptic plasticity and memory formation.
A Draft Male Genome Assembly of the Slipper Lobster (Thenus australiensis) Reveals an XY System and a Validated Diagnostic Marker for Monosex Aquaculture. biorxiv.org 2026-06-29 The slipper lobster (Thenus australiensis) is rapidly emerging as a high-potential species for commercial aquaculture.
Single-cell transcriptomics reveals chondrocyte state transitions and ECM remodeling in osteoarthritic knee cartilage biorxiv.org 2026-06-29 Osteoarthritis cartilage has heterogeneous chondrocyte states, yet their transitions remain unresolved from public single-cell data.
Collinearity of Decomposed Energy Terms in MM-GBSA Binding Free Energy Calculations biorxiv.org 2026-06-29 The molecular mechanics-generalized Born surface area method (MMGBSA) is one of the most commonly used end state approaches used for the calculation o