Where do the ligands bind? Co-folding bitter taste GPCRs with the BitterDB chemical space biorxiv.org 2026-06-27 Bitterness is a key taste modality mediated in vertebrates by TAS2R G protein coupled receptors, which also function in diverse extraoral tissues.
Improving oral dissolution kinetics of weakly basic vodobatinib via slurry conversion to an amorphous drug-polymer salt biorxiv.org 2026-06-27 Vodobatinib (VBN) is a weakly basic (pKa {approx} 2.3), anticancer treatment with poor enteric solubility and low oral bioavailability.
ProLoc: Text-guided Localization of Protein Functional Regions biorxiv.org 2026-06-27 Motivation: Protein function is often mediated by specific sequence regions, such as domains, motifs and functional sites.
Glitch genes: embedding geometry predicts functional fragility in single-cell foundation models biorxiv.org 2026-06-27 Background: Single-cell foundation models are increasingly used for perturbation prediction and gene network inference, but their learned gene represe
The Hidden Disorder Divide: Reconciling Benchmark Inconsistencies in Intrinsically Disordered Protein Binding Site Prediction biorxiv.org 2026-06-27 Computational predictors of protein-binding sites within intrinsically disordered regions (IDRs) show highly inconsistent performance across high-qual
UTRGen: A unified framework for full-spectrum design of mRNA 5' UTRs biorxiv.org 2026-06-27 The 5' untranslated region (5' UTR) is a key regulatory element that governs mRNA translation and protein output.
Stability-driven multi-omics integration for reproducible latent structure biorxiv.org 2026-06-27 High-dimensional multi-omics data integration offers novel opportunities to characterize complex biological systems.
BoltzProt-1: Towards Efficient De Novo Binder Design with Good Developability biorxiv.org 2026-06-27 Designing binders against novel protein targets remains a central challenge in computational drug discovery.
eRNAformer enables genome-wide de novo mapping of enhancer-derived RNA loci biorxiv.org 2026-06-27 Enhancer-derived RNAs (eRNAs) are critical regulators of gene transcription, yet their genome-wide annotation remains challenging.
Influence of Non-Specific Surface Adhesion on the Shape and Microrheology of Red Blood Cells biorxiv.org 2026-06-27 Poly-L-Lysine (PLL) mediates the non-specific adhesion of cells and is commonly used in Atomic Force Microscopy (AFM) measurements, to ensure that cel
Repetitive anatomical patterns for thalamocortical projections of higher-order thalamic nuclei biorxiv.org 2026-06-28 Cortico-thalamo-cortical circuits entail extensive trans-thalamic connectivity between cortical areas, yet their structural organization and function
Individual strategies for ignoring irrelevant information are reflected in distinct neural signatures during temporal attention. biorxiv.org 2026-06-28 Attentional functions enable the nervous system to regulate incoming information, selecting what is behaviorally relevant while filtering out distract
Estimation of neuronal tuning for word meaning from passively recorded naturalistic speech biorxiv.org 2026-06-28 The ability to derive neural-level language coding models holds great scientific and clinical potential.
Instrumental-Motor Transfer: The Relative Value of Competing Movement Goals Modulates Implicit Motor Learning biorxiv.org 2026-06-28 Multiple learning signals can shape motor output, including reward and punishment (via value-based reinforcement learning) and sensorimotor error (via
Reconstruction of critical-sized mandibular defects in a sheep model using a PLLA-PGA-CC scaffold biorxiv.org 2026-06-27 Introduction: Critical-sized bone defects cannot heal spontaneously, requiring additional, often burdensome, treatment.
A Multiscale Computational Analysis of Myometrial Excitation during Late Pregnancy biorxiv.org 2026-06-27 The control of uterine activity during pregnancy is a complex process that involves regulating myometrial excitability across multiple scales.
Rapid urban evolution of the dengue mosquito in West African cities biorxiv.org 2026-06-26 Aedes aegypti is an exceptionally effective global vector of human disease because of its strong specialization on human hosts and habitats.
Thermally driven sex reversal reveals divergent sex determination dynamics in wild viviparous reptile populations biorxiv.org 2026-06-26 Climate change can threaten population viability by disrupting sex ratios in species whose sex is influenced by temperature.
Single cell genomics and fluorescence microscopy suggest a permanent plastid in a marine centrohelid biorxiv.org 2026-06-26 Photosynthetic organelles (plastids), which originated via primary endosymbiosis between an Archaeplastida ancestor and cyanobacteria, have shaped the
Transformation and allelic exchange in Orientia tsutsugamushi biorxiv.org 2026-06-26 Orientia tsutsugamushi is a mite-transmitted obligate intracellular bacterium that causes the potentially deadly zoonosis, scrub typhus.
EpiATLAS - a reference for human epigenomic research biorxiv.org 2026-06-26 The sequence of the human genome provides a foundation for understanding cellular processes in health and disease.
Mapping the genetic architecture of human cortical expansion and its links to neuropsychiatric disorders biorxiv.org 2026-06-26 Cortical expansion is a defining feature of human evolution and neurodevelopment, involving the tangential growth and gyrification of the cerebral cor
Intrinsic promoter responsiveness dictates sensitivity to transcriptional activation by enhancers biorxiv.org 2026-06-26 Enhancers activate specific target promoters, but whether intrinsic enhancer-promoter compatibility contributes to this specificity is debated.
Mapping non-coding functional elements in allotetraploid Cyprinus carpio embryo development reveals subgenome variation of transcription regulation biorxiv.org 2026-06-26 Common carp (Cyprinus carpio) is an important freshwater species for ornamental and aquaculture purposes, and a key cyprinid model for studying allote
Beyond paternal care: career stage and reproductive opportunities shape male services in vervet monkeys biorxiv.org 2026-06-26 Why male primates invest in costly behaviours producing public goods remains debated, with two leading explanations, paternal care and reputation-base
Dynamics of individual visual biases in space and time biorxiv.org 2026-06-26 Recent work has brought to light a number of stimulus families whose perception is shaped by strong idiosyncratic biases.
Electron confurcation drives photosynthetic H2 production in cyanobacteria biorxiv.org 2026-06-26 Cyanobacteria are major contributors to global photosynthesis and are intensively studied for sustainable green H2 production.
Conversion of a Viral Glycan Shield into a Binding Anchor via Causal-Driven Antibody Optimization biorxiv.org 2026-06-26 Therapeutic antibodies are challenged by rapidly evolving pathogens that exploit glycosylation to shield epitopes.
Agentic AI for Structural Elucidation and Discovery of Drug Metabolites from Mass Spectrometry Data biorxiv.org 2026-06-26 The majority of chemical signals detected in public metabolomics repositories remain structurally undefined.
The Gompertz curve for estimating growth rates of Protein Data Bank and protein folds biorxiv.org 2026-06-26 The Protein Data Bank (PDB) is an ever-growing, open-access repository of structural data of biological molecules.