AMaNITA: an end-to-end workflow for native tRNA nanopore sequencing data analysis biorxiv.org 2026-06-17 Transfer RNA (tRNA) molecules serve as essential adapters during protein translation.
Mechanistic Insights into Unfolding of the Mitochondrial Localization Sequence M1 of TDP-43 and Identification of a MAPKAPK2 Inhibitor as a potential binder of M1 for inhibition of TDP-43's Aberrant Mitochondrial Localization biorxiv.org 2026-06-17 Mechanistic elucidation and inhibition of the pathogenic aberrant mitochondrial localization of the RNA/DNA-binding protein, TDP-43, can help in the t
Negative and neutral interactions are prevalent in interactions between marine chitin degraders biorxiv.org 2026-06-17 Bacterial chitin degradation contributes to global carbon cycling, particularly in marine environments where it is a highly abundant polysaccharide.
Microbial community-based single-cell protein supports partial fishmeal replacement in juvenile Asian seabass diets across feeding trials and production scales biorxiv.org 2026-06-17 The growing demand for sustainable aquafeeds has intensified interest in alternative protein ingredients capable of reducing reliance on fishmeal with
High-resolution transcriptome analysis reveals a multilayered and dynamic transcriptional architecture in the archaeal virus SSV1 biorxiv.org 2026-06-17 Fuselloviridae infecting thermoacidophilic Sulfolobales are among the best-studied archaeal viruses, with the Saccharolobus Spindle Shaped Virus 1 (SS
The effects of thermal alteration on organic matter bioavailability in deeply buried marine sediments biorxiv.org 2026-06-17 A substantial fraction of marine sediments experience elevated temperatures due to burial or hydrothermal activity.
Cross-study metagenomics analysis reveals distinct microbial signatures of urinary tract infections biorxiv.org 2026-06-17 Background: Urinary tract infections (UTIs) represent a major public health concern, increasingly complicated by rising antibiotic resistance, diminis
Ferrosome Organelles Spatially Insulate a Redox-Active Ferrous Phosphate Biomineral from Cytosolic ROS Chemistry biorxiv.org 2026-06-17 Ferrosomes are recently discovered lipid-bound bacterial organelles that store iron as iron-phosphate biominerals, yet the chemical nature and physiol
Systematic evaluation of Cyanidioschyzon merolae across photobioreactor systems: Linking reactor design to biomass production and biochemical composition biorxiv.org 2026-06-17 Extremophilic red microalgae are promising platforms for sustainable biotechnology, combining robust growth under selective thermoacidophilic conditio
From parental antibiotics to offspring locomotion: L-norvaline links microbiome disruption to intergenerational reprogramming in Drosophila biorxiv.org 2026-06-17 The maternal microbiome during oogenesis is a critical but underappreciated regulator of offspring physiology.
Spatial organization of self-assembled G-quadruplex nucleic acids tunes extracellular electron transfer in pathogenic biofilms biorxiv.org 2026-06-17 Extracellular electron transfer (EET) allows bacteria to sustain metabolism when soluble electron acceptors such as oxygen are scarce, a situation typ
Insertions in universal proteins confirm that Nanohaloarchaea belong to DPANN-Archaea and suggest several new major archaeal clades. biorxiv.org 2026-06-17 The phylogenetic position of Nanohaloarchaea has been debated, these nanosized archaea being alternatively proposed as sister group to Haloarchaea, me
DesignMaster: A Multi-Conditional Diffusion Framework for Rational PROTAC Design biorxiv.org 2026-06-17 Motivation: Proteolysis-targeting chimeras (PROTACs) enable targeted protein degradation through ternary complex formation with E3 ubiquitin ligase.
DNA-binding specificity recognition from predicted homologous protein-DNA structures biorxiv.org 2026-06-17 Predicting protein DNA-binding specificity is essential for understanding gene regulation and disease mechanisms.
Borrelia burgdorferi bb0164 encodes a Na+/Ca2+ antiporter homolog with a novel role in Mn2+ homeostasis and infectivity biorxiv.org 2026-06-17 Borrelia burgdorferi, the Lyme disease causative agent, relies on trace metals for motility, growth, and virulence in the absence of metal transport h
Toward understanding drivers of specialized metabolism in Actinomycetota: insights from 1432 transcriptomics datasets for 132 strains biorxiv.org 2026-06-17 Actinomycetota are major sources of specialized metabolites with applications in drug discovery and agriculture, yet much of their biosynthetic potent
A strain-specific metabolic role for the UDP-glucose 4-epimerase Uge3 in Aspergillus fumigatus virulence biorxiv.org 2026-06-17 Expression of a fungal-specific sub-telomeric gene, hrmA, in Aspergillus fumigatus is important for a colony biofilm morphology termed H-MORPH, increa
High-Throughput Profiling of Bacterial Respiration Using the Resipher Reveals Functional Responses to Nutrients and Antibiotics biorxiv.org 2026-06-17 Oxygen consumption is a direct functional readout of bacterial respiration and metabolic state, yet existing methods for quantifying oxygen dynamics a
Ecological inference and contaminant detection from fungal microbiome data with q2-fungal-traits biorxiv.org 2026-06-17 Fungi are key members of microbial communities, yet microbiome surveys often lack trait-based information required for ecologically meaningful interpr
RNA-dependent aggregation of a common TEV protease variant alters in vitro biomolecular condensate reconstitution biorxiv.org 2026-06-17 Biomolecular condensates formed by liquid-liquid phase separation (LLPS) are commonly studied in vitro using protease-mediated removal of solubilizing
mRNA concentration-dependent translation enables rapid and sharp patterning in resource constraint Drosophila embryos biorxiv.org 2026-06-17 One of the fundamental challenges in protein expression during embryogenesis is the establishment of dynamic protein patterns under the resource const
An Antibiotic-Treated Mouse Model Reveals the Progression of Intestinal Botulism biorxiv.org 2026-06-17 Intestinal botulism, including infant botulism and adult intestinal toxemia botulism, is a life-threatening disease caused by intestinal infection wit
Signaling input from the polar flagellum uncouples quorum sensing from cell-density regulation in Vibrio species biorxiv.org 2026-06-17 Quorum sensing (QS) is traditionally recognized as a signaling mechanism that monitors cell density to coordinate bacterial group behaviors.
Virus-host interactions on volcanic ash from Mount Etna biorxiv.org 2026-06-17 Volcanic ash represents an extreme and dynamic habitat, yet it hosts diverse microbial communities with largely unexplored viral diversity.
Antibiofilm peptide incorporated PHBV-PLLA nanofibrous mat for wound infection treatment and healing biorxiv.org 2026-06-17 Tissue regeneration using bioactive biomaterials has made great progress in the field of wound healing.
Servo-Actuated 3D-Printed Disposable Microvalves for Automated, Scalable Organoid Culture in Standard Incubators biorxiv.org 2026-06-17 Automation of organoid and cell culture processes is essential for achieving scalable and standardized experimentation in regenerative medicine and st
Cyclic stretch inhibits cell invasion in 3D scaffolds biorxiv.org 2026-06-17 Background: The development of clinically viable tissue-engineered heart valves (TEHVs) remains limited by inconsistent host cell infiltration.
A Pro-Regenerative Petroleum Jelly-Based, Copper-Doped Bioactive Glass Ointment for Impaired Wound Healing in Metabolic Syndrome biorxiv.org 2026-06-17 Chronic wound healing is often impaired in conditions such as metabolic syndrome, requiring effective therapeutic interventions to promote tissue rege
Posterior-calibrated multimodal motor states reveal longitudinal and imaging-associated heterogeneity in Parkinson's disease biorxiv.org 2026-06-17 Parkinson's disease (PD) motor heterogeneity is commonly summarized by hard subtype labels, although clinical states vary longitudinally, severity can
Correcting spatial transcriptomics data affected by a prevalent transcript leakage problem across platforms, species, and tissues biorxiv.org 2026-06-17 Spatial transcriptomics has been widely applied to study the spatial distribution of cell types, cell states, and specific gene expression in tissue s