Spectral decompositions of neural voltage recordings are susceptible to model misspecifications that cause meaningful estimation error biorxiv.org 2026-06-16 The power spectra of neural voltage recordings vary systematically across brain states and contain both narrowband (rhythmic) and broadband components
Biodiversity data portals as methodological filters for iNaturalist: how platform choice can shape biodiversity assessments biorxiv.org 2026-06-16 iNaturalist has rapidly grown to become one of the largest contributors of global biodiversity data, being widely used in academic research, to suppor
Programmatic access to ICTV virus taxonomy through a public ontology API biorxiv.org 2026-06-16 The International Committee on Taxonomy of Viruses (ICTV) is responsible for developing and maintaining a universal virus taxonomy.
Evidence for recombination in dengue virus genomes biorxiv.org 2026-06-16 Recombination is a key driver of RNA virus evolution, yet its extent and evolutionary implications in dengue virus (DENV) remain incompletely understo
Metabolic Gating and the Evolution of Human Cognitive Plasticity: A Comparative Genomic Analysis biorxiv.org 2026-06-16 The genetic basis of extreme cognitive plasticity in human innovators remains poorly characterized.
Single cell in vivo analysis of type I IFN and NK cell-mediated control of B cell infection densities during acute gammaherpesvirus infection biorxiv.org 2026-06-16 Immunodeficient patients are at risk of severe complications following infection with the human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi
Structural Basis of Nidovirus Replication Organelle Evolution Revealed by the Arterivirus DMV Pore Complex biorxiv.org 2026-06-16 Positive-strand RNA viruses of the order Nidovirales - which include coronaviruses and arteriviruses - remodel host membranes into double-membrane ves
Aedes vittatus in Haiti: continued expansion across the Caribbean and implications for the Americas biorxiv.org 2026-06-16 Aedes vittatus, an emerging invasive species and arboviral vector with high ecological plasticity and dispersal capacity, is expanding in the Caribbea
Record-breaking wildfire intensity and nocturnal spread during the extreme 2025 wildfire season in Southwestern Europe: causes and impacts biorxiv.org 2026-06-16 Southwestern Europe faced an extreme wildfire season in 2025, with nearly 700,000 hectares burned in the Iberian Peninsula (IP) alone.
Temporal genomics reveals rapid parallel adaptation in experimental populations of Trinidadian guppies (Poecilia reticulata) biorxiv.org 2026-06-16 Understanding the genomic basis of early adaptation is a central question in evolutionary biology.
CMAPLE 2: Fast and Accurate Phylogenetic Inference for Millions of Pathogen Genomes biorxiv.org 2026-06-16 Phylogenetic analysis is essential to genomic epidemiology, for example in tracing the origin and evolution of SARS-CoV-2 variants during the COVID-19
Summarizing Evolutionary Trajectories from Phylogenetic Character Maps of Discrete Traits biorxiv.org 2026-06-16 When reconstructing phylogenetic character histories, biologists aim to identify distinct evolutionary trajectories, or paths of character state evolu
Population bottlenecks shape laboratory evolution of piperacillin-tazobactam resistance in Klebsiella grimontii and reveal a shared within-patient evolutionary trajectory biorxiv.org 2026-06-16 Laboratory-based experimental evolution is widely used to investigate how antimicrobial resistance (AMR) emerges and to identify resistance-associated
Long-read genome sequencing reveals complex variability in lentiviral provirus insertions in deeply characterized Clonal CD19 CAR-T vector copy number reference cell lines biorxiv.org 2026-06-16 Chimeric antigen receptor (CAR)-T cell therapy is an important therapy involving provirus insertions in the genome.
Vascular and synaptic proteomes reveal blood-brain barrier disruption and postsynaptic remodeling in human temporal lobe epilepsy biorxiv.org 2026-06-16 Blood-brain barrier (BBB) dysfunction and mesial temporal lobe epilepsy (MTLE) are considered to be engaged in a pathological feedback loop, with the
Genetic dependency of atrial fibrillation-associated risk genes across tissue types: Discovering novel therapeutic targets biorxiv.org 2026-06-16 Background: Addressing the underlying causes of atrial fibrillation (AFib) is critically important.
Design of a Low-Latency sEMG Real-Time Correction System Based on High CMRR and EMRMS Mathematical Modeling biorxiv.org 2026-06-16 Wildlife poaching threatens biodiversity across sub-Saharan Africa, and is especially acute for critically endangered species such as the black rhinoc
A Transformer-derived transcriptomic score associates with ex-vivo drug response in AML biorxiv.org 2026-06-16 Background Drug-tolerant persister (DTP) cell states have been implicated in relapse across multiple cancers, including acute myeloid leukaemia (AML)
scIsoAgent enables autonomous isoform-resolved characterization and sequence-informed interpretation of long-read single-cell transcriptomes biorxiv.org 2026-06-16 Alternative isoform usage can alter gene function independently of total gene expression, creating a need to resolve transcript isoforms at single-cel
A minimal thermodynamic theory for re-entrant liquid-liquid phase separation regulated by small molecules biorxiv.org 2026-06-16 Small molecules regulate biomolecular condensates in a biphasic manner, promoting liquid--liquid phase separation (LLPS) at low concentrations while s
First Plant sedaDNA assemblage from California reveals ecological stability throughout 10,000 years of human presence at Lake Elsinore biorxiv.org 2026-06-16 As we face the sixth mass extinction, understanding how ecosystems have persisted -- or collapsed -- through millennia of changing climates and human
Developmental Continuity of Brain Network Core Organization in C. elegans biorxiv.org 2026-06-16 The brain is the most captivating chef d'oeuvre of nature. Naturally then, the mind wonders about the process that births such a fascinating organ.
Autophagy suppresses microglial activation and enhances M2 polarization via the mTOR/ULK1 pathway after optic nerve crush biorxiv.org 2026-06-16 This study is designed to investigate whether rapamycin can regulate microglial activation and polarization via mTOR and its downstream signals via au
GPCR-mediated regulation of glial TNF production biorxiv.org 2026-06-16 Neuromodulators generally act through G-protein-coupled receptors, but their effects on glia are not well defined.
Visual consequences of saccades explain early cortical response dynamics during natural vision biorxiv.org 2026-06-16 During natural vision, each saccadic eye movement evokes a large cortical potential known as the lambda response.
Cognitive Control Adjusts to Behavioral Constraints at Short Timescales biorxiv.org 2026-06-16 Cognitive functions encompass a large set of abstract constructs used for adapting our behavior to environmental constraints, each of them acting at s
Aligned multicompartment collagen scaffolds support stratified myoblast and fibroblast behavior for musculotendinous tissue engineering biorxiv.org 2026-06-16 Injuries to musculoskeletal tissue junctions are exceedingly common and notoriously difficult to repair due to the inability to restore overlapping gr
Machine learning surrogate forward models for biomechanical laryngeal control biorxiv.org 2026-06-16 Accurate modeling of laryngeal motor control is key to understanding typical and disordered voice production.
Super-Resolved Single Small Extracellular Vesicle Assay enabled by a Plasmonic Nanohole Array biorxiv.org 2026-06-16 The accurate quantification of biological nanoparticles, such as small extracellular vesicles (sEVs), is fundamentally hindered by a resolution-coinci
Filling the Void: Rapid Revascularization via Vasculogenic Assembly in Semi-synthetic Granular Hydrogel Grafts biorxiv.org 2026-06-16 Rapid revascularization is critical to tissue graft survival, as delayed reperfusion drives tissue ischemia and compromises cell viability and graft f