Precision Functional Parcellation of the Human Cortex via Rest-Task fMRI Fusion biorxiv.org 2026-06-16 Individual-specific cortical parcellations enable the characterization of brain network organization that is often ob-scured by population-level atlas
The CYP27A1 - VDR Feedback Rheostat Controls Mitochondrial Protein Homeostasis and Preserves Hippocampal - Striatal Network Integrity to rescue Cognitive impairment in HD condition biorxiv.org 2026-06-16 Emerging evidence links vitamin D (VD) deficiency to cognitive and motor dysfunction in Huntington's disease (HD), yet the underlying mechanism remain
Structure of the proton-powered secretion motor at the heart of the bacterial flagellum biorxiv.org 2026-06-15 Bacterial type III secretion systems export proteins across the inner membrane using the proton-motive force (PMF), but how proton flow is coupled to
HIV-1-induced small T cell syncytia: susceptibility to direct NK cell killing biorxiv.org 2026-06-15 Intravital imaging studies of HIV-1-infected humanized mice by three independent groups revealed the presence of small T cell syncytia.
A novel High-Throughput Ligase-Independent Mapping method to detect Viral Integration Sites biorxiv.org 2026-06-15 Integrated DNA elements are central to virology, functional genomics, and gene therapy, but current insertion-site mapping methods often rely on restr
Long-read single-cell genomics: resolving chimeras in multiple displacement amplification biorxiv.org 2026-06-15 Multiple displacement amplification (MDA) enables whole-genome amplification from single cells, but introduces chimeric artifacts that severely compro
DAQplugin: Deep Learning based Real-time Model Evaluation Plugin for ChimeraX biorxiv.org 2026-06-15 Although an increasing number of protein structures are determined by cryogenic electron microscopy (cryo-EM), protein structure modeling frequently s
Stressor- and tissue-specific regulation of the corticotropin-releasing factor system across epithelial tissues in rainbow trout biorxiv.org 2026-06-15 The corticotropin-releasing factor (CRF) system is a major neural regulator of stress responses in vertebrates.
Distinct types of gut dysbiosis and oral-gut microbial signatures differentiate C. difficile, Campylobacter, and Salmonella infections: a cross-sectional study biorxiv.org 2026-06-15 Gastrointestinal bacterial infections are associated with substantial perturbations of the gut microbiota, yet most microbiome studies have examined i
Does media matter? Growth environment influence antimicrobial tolerance and expression of virulence and transmembrane ion transport-associated genes in MRSA biorxiv.org 2026-06-15 Clinically relevant pathogens are often tested for antimicrobial susceptibility using standard laboratory media that poorly reflect the in vivo enviro
Trichomonas vaginalis pseudocysts are a quiescent cell stage characterized by a differentially regulated transcriptome and intact membranes biorxiv.org 2026-06-15 Trichomonas vaginalis is the causative agent of trichomoniasis, the most common non-viral sexually transmitted infection (STI).
A Single-Dose Bundibugyo Virus Vaccine Protects Macaques Within 3 Days biorxiv.org 2026-06-15 Bundibugyo virus (BDBV), a member of the orthoebolaviruses in the Filoviridae family, causes severe hemorrhagic disease with high case-fatality rates.
The genome of the coffee bean weevil (Araecerus fasciculatus) reveals a cytochrome P450 repertoire as a convergent candidate mechanism of insect-origin caffeine detoxification biorxiv.org 2026-06-15 The coffee bean weevil, Araecerus fasciculatus (Coleoptera, Curculionoidea, Anthribidae), is a cosmopolitan pest of over 100 stored agricultural commo
Mycoplasma immunoglobulin binding protein universally binds human antibodies, thereby reducing Fab arm flexibility and displacing antigens in immune complexes biorxiv.org 2026-06-15 Mycoplasma immunoglobulin binding (MIB) protein plays a key role in immune evasion across several Mycoplasma species.
From Brain Microstructure to Dynamics: Linking Grey and White Matter Architecture to Propagation Delays biorxiv.org 2026-06-16 Understanding the relationship between neural dynamics and underlying brain structure, and in particular the impact of the latter on conduction delays
Cognitive function depends upon Satb2 gene dosage in cortical projection neurons biorxiv.org 2026-06-16 SATB2-associated syndrome (SAS) is a severe neurodevelopmental disorder caused by de novo heterozygous SATB2 mutations, yet how haploinsufficiency dis
Measurement and comparison of acoustic space use in vocalizations of humans and close primate relatives biorxiv.org 2026-06-16 The human larynx, compared to those of closely related primates, lies deeper in the throat and lacks vocal membranes and air sacs.
Wild chimpanzee groups increase social connectivity prior to risky collective action biorxiv.org 2026-06-16 Cooperation is foundational to complex sociality, yet presents profound evolutionary dilemmas - costs and benefits are rarely distributed evenly and t
Expanding gene regulatory networks from transcriptome data through graphical modeling with heterogeneous priors biorxiv.org 2026-06-16 Gene regulatory network inference is widely used to reconstruct large-scale networks and identify functional genes from transcriptome data.
A framework for the organization of microtubules in developing neurons biorxiv.org 2026-06-16 The development and physiology of neurons rely on their microtubule organization, which is characterized by plus-end-out oriented microtubules in the
Electrophysiological properties and synaptic activity of the mouse hippocampal CA1 neurons during postnatal development biorxiv.org 2026-06-16 Early postnatal development is a critical period for hippocampal circuit maturation.
Multiple motor proteins regulate ALS-linked TDP-43 anterograde axonal transport biorxiv.org 2026-06-16 TDP-43 is an RNA-binding protein essential for RNA metabolism.
The frequency dependence of EEG-speech envelope tracking does not reflect the rates of speech units or pitch biorxiv.org 2026-06-16 During speech listening, neural activity partly synchronises to fluctuations in the acoustic amplitude envelope of the stimulus.
Dynamic geometry remapping of neural activity within frontal and subcortical areas during decision-making biorxiv.org 2026-06-16 Decision-making involves dynamic evaluation of competing options.
Language Immersion Enhances Attentional Speech Processing via Low-Frequency Neural Tracking biorxiv.org 2026-06-16 Language experience is a powerful driver of neurocognitive plasticity, shown to modulate attentional and executive processing in speakers of multiple
FMR1 gene therapy restores activity-driven inhibition and prevents audiogenic seizures in Fmr1-/y mice biorxiv.org 2026-06-16 Fragile X syndrome (FXS) is a neurodevelopmental disorder associated with auditory hypersensitivity, circuit hyperexcitability, and seizures.
KCNQ2/3 Regulates the Synaptic Remodeling Associated with Drug Seeking in Addiction biorxiv.org 2026-06-16 Drug-seeking behavior during withdrawal represents a critical obstacle to addiction treatment.
Sensorimotor dynamics of target acquisition and homing in human echolocation biorxiv.org 2026-06-16 Blindness imposes constraints on the acquisition of environmental sensory information.
A microcircuit model of astrocytic potassium buffering and neural synchronization biorxiv.org 2026-06-16 Neural synchronization is fundamental to brain function and, when it becomes excessive, underlies pathological conditions such as epilepsy.
Distributed neuronal ensembles support episodic-like memory retrieval biorxiv.org 2026-06-16 Memory is proposed to depend on neuronal ensembles distributed across multiple brain regions, yet how episodic-like memories are organized across the