Generative design of antigen-specific T-cell receptor sequences with a conditional diffusion model biorxiv.org 2026-06-14 T cell receptor (TCR)-based immunotherapy holds immense potential for treating cancers and infectious diseases, where highly antigen-specific TCR reco
Ingestion of the potent neurotoxin epibatidine does not compromise locomotion or behavior in the poison frog Epipedobates tricolor biorxiv.org 2026-06-14 Most organisms have evolved mechanisms to reduce the negative effects of toxins in their diet.
Experimental breeding reveals mating patterns and F1 phenotypic diversification in the cosmopolitan diatom Cylindrotheca biorxiv.org 2026-06-14 Diatom mating activity contributes to their enormous phenotypic and genetic diversity, yet little is known about patterns in diatom reproductive compa
Freshwater input and tidal position regulate species turnover and interaction rewiring in intertidal ecological networks biorxiv.org 2026-06-14 The effect that environmental conditions have on community and network assembly processes remains unclear, in part because these processes operate at
Attenuation of Inflammatory Cytokines by Selective Vagal Motor Stimulation via Silicone Spiral Nerve Cuff biorxiv.org 2026-06-14 Objectives To determine how selective optogenetic vagus nerve stimulation (VNS) of distinct axonal subpopulations modulates systemic inflammatory cyto
Structural Analysis of Prostate Cancer N-Glycans Using Graph-Based Structural Metrics biorxiv.org 2026-06-14 The N-linked glycans are structurally complex carbohydrate modifications that regulate protein folding, immune recognition, and cellular signaling, an
Cellfm-datasets: A Unified Data Infrastructure for Single-Cell and Spatial Transcriptomics Foundation Model Pretraining biorxiv.org 2026-06-14 Large-scale cell foundation models are increasingly limited not only by model architecture, but also by the data infrastructure required to repeatedly
Systematic AI-Driven Drug Repurposing via Clinical Trial Data Mining: A Framework and Six Cross-Therapeutic Case Studies. biorxiv.org 2026-06-14 Drug repurposing, the application of approved or shelved compounds to new therapeutic indications, offers a cost- and time-efficient alternative to de
APpar: automated action potential parameter analysis software for reproducible electrophysiological measurements in neurons biorxiv.org 2026-06-14 Quantitative analysis of action potential (AP) waveforms is central to studies of neuronal excitability, ion channel function, disease mechanisms, and
Improving All-Atom Molecular Dynamics Models for Quantitative Prediction of Nanopore Blockade Current biorxiv.org 2026-06-14 All-atom molecular dynamics has become an indispensable tool in development of nanopore sensors of biological information.
Effects of oxidative stress and aging on nerve, muscle, and synapse in a male-specific abdominal neuromuscular junction in Drosophila biorxiv.org 2026-06-14 Defects in Drosophila Cu2+/Zn2+ superoxide dismutase (encoded by the gene Sod1) lead to elevated oxidative stress and a drastically shortened lifespan
Lysosomal ion homeostasis drives delayed hair cell death after aminoglycoside uptake. biorxiv.org 2026-06-14 Aminoglycoside ototoxicity has been widely reported and remains an important public health issue.
Prediction of parsimonious and temporally sensitive sets of cell fate engineering transcription factors with IMCell biorxiv.org 2026-06-14 Transcription factor (TF) cocktails used in cell identity reprogramming protocols have largely been developed from experimental approaches.
A Forward Genetic Screen in Caenorhabditis elegans for Genes that Modulate α-synuclein-Induced Neurodegeneration through the Mitochondrial UPR biorxiv.org 2026-06-15 Overexpression of -synuclein (-syn), an inherently disordered protein, triggers chronic activation of the mitochondrial unfolded protein response (UPR
Hypermutability of ultraconserved histone genes and its contribution to human disease biorxiv.org 2026-06-14 Histone genes are among the most evolutionarily conserved sequences in eukaryotes, reflecting their essential role in nucleosome architecture.
Bioclimatic variables influence the strength of purifying selection on mitochondrial DNA in an avian clade (Aves: Piciformes) biorxiv.org 2026-06-14 Mitochondrial loci were for long considered as markers of choice to reconstruct phylogenies.
Identifying transcriptomic bias across developmental shifts in insects biorxiv.org 2026-06-14 Background Synonymous mutations, once considered neutral, can affect translation efficiency through mRNA folding and splicing, generating codon usage
Evolutionary Recoding of Olfactory Sensory Neurons biorxiv.org 2026-06-14 Odorant receptors (Ors) are the interface between an animal's nervous system and its olfactory environment.
Organelle Capture, Lineage-Specific Genomic Responses, and the Lability of Dioecy in Amaranthus biorxiv.org 2026-06-14 The transition from combined to separate sexes in plants drives genomic change, from recombination suppression at sex-determining loci to shifts in se
Morphological shifts consistent with the island syndrome in land-bridge island birds biorxiv.org 2026-06-14 Land-bridge islands are former mainland areas isolated by post-glacial sea-level rise (<15,000 years) and the most common island type.
Transposable elements as evolutionary substrates of proteindisorder in the human proteome biorxiv.org 2026-06-14 Intrinsically disordered regions (IDRs) are central contributors to protein function, evolution and human disease, yet the evolutionary routes that se
TopoMIL: Topology Improves Multiple Instance Learning in Diagnostic Microscopic Images biorxiv.org 2026-06-14 Microscopic images of cells and tissues are central to disease diagnosis.
A novel machine-learning classification model detects oxidative fiber type transitions in a rabbit model of cerebral palsy biorxiv.org 2026-06-14 The distribution of slow- and fast-twitch fiber types in a skeletal muscle heavily influences its physiology.
Genetic analysis of maize seedling root traits under chilling highlights their importance for early field development biorxiv.org 2026-06-14 Characterizing the genetic basis of root system architecture and its role in early plant development is essential for developing maize varieties with
Cardiomyocytes Undergo a Mesenchymal-Like Fate Transition in Myocardial Fibrosis biorxiv.org 2026-06-14 BACKGROUND Myocardial fibrosis, a pathological hallmark of adverse cardiac remodeling and heart failure, has been conventionally attributed to the act
Mutation count and mutation profile analyses of single-nucleotide variants in single human colon crypts biorxiv.org 2026-06-14 Genetic heterogeneity due to the accumulation of mutations in normal tissues can increase cancer risk and be an important factor in many age-related d
Robust integration of weakly anchored spatial multi-omics biorxiv.org 2026-06-14 Spatial multi-omics holds great promise for dissecting complex biological processes, though inherent technical constraints continue to limit its wides
Somatic variant detection in normal tissues from single-cell sequencing data biorxiv.org 2026-06-14 A crucial advantage of single-cell sequencing (SCS) is its ability to identify somatic variants in individual cells, enabling phylogenetic analysis of
Escherichia coli and Mammalian Cells Follow Divergent Rules for Lipid-Driven Cytosolic Accumulation biorxiv.org 2026-06-14 While lipidation is a widely observed strategy to promote membrane permeation, whether the factors governing lipid-driven accumulation are shared acro
Membrane-dependent structural organization of cowpox virus CPXV012 and its recognition of TAP biorxiv.org 2026-06-13 Cowpox virus CPXV012 inhibits MHC class I antigen presentation by interfering with TAP-dependent peptide transport, but its membrane-dependent structu