Co-Expressed MicroRNAs Identify Potential Mechanisms Underlying Risk for Multimorbid Depression and Type 2 Diabetes in Midlife Women biorxiv.org 2026-06-12 Background Women are disproportionately affected by multimorbid depression and type 2 diabetes (T2D), with prevalence peaking during midlife (40-64 ye
Effects of Left Atrial Wall Thickness on Myocardial Mechanics and Blood Dynamics using Multiscale Modeling biorxiv.org 2026-06-12 Purpose: Patient-specific models of left atrial (LA) mechanics often assume uniform left atrial wall thickness (LAWT), but the effect of LAWT on the m
Receive-Only Coupled Wireless Radiofrequency Probe for Endocavity MR Imaging Using a pTx System biorxiv.org 2026-06-12 Purpose: To enhance the SNR in MRI within a localized region of interest using a novel interventional wireless RF resonator probe combined with a dual
A Graph-based QSAR Modeling Pipeline for Predicting In vitro PubChem Assays and In vivo Human Hepatotoxicity: Mechanistic Analysis of Caspase-3/7 Activation biorxiv.org 2026-06-12 Background: Caspase-3 and -7 are key effector caspases in the apoptotic pathway, a form of programmed cell death, and their activities serve as a well
Inhibition of NSD1 by 5-O-Sulfamoyl Adenosine improved 5-FU sensitivity by suppressing cancer cell proliferation and xenograft tumor growth biorxiv.org 2026-06-12 Epigenetics regulate cell-cycle kinetics, differentiation, apoptosis, and migration.
Systematic Profiling and Functional Characterization of Alternative Splicing in C. elegans Olfactory Learning biorxiv.org 2026-06-12 Alternative splicing (AS) is prevalent in neuronal gene expression. However, its function in learning has not been systematically characterized.
Video-based eye movements are linked to cortical and pupil-based arousal in human sleep biorxiv.org 2026-06-12 Study Objectives To quantify high-resolution video-based eye kinematics across sleep macro- and microstructure and determine their coupling with pupil
A transient CD87-centred axis enhances the Th17 potential of cDC2 in neonates biorxiv.org 2026-06-12 Type 2 conventional dendritic cells (cDC2) orchestrate T cell immunity, yet the signals that regulate their tissue-specific functions across developme
Monoclonal nephritic factors reveal insights into C3 convertase dynamics and dysregulation biorxiv.org 2026-06-12 C3- and C5-nephritic factors are potent but poorly understood autoantibodies that dysregulate complement convertases.
Gonadal regulation of sex-specific immunity in tuberculosis: enhanced lymphocyte function in females and dysfunctional myeloid responses in males biorxiv.org 2026-06-12 Tuberculosis (TB), the worlds deadliest infection, shows higher prevalence and mortality in males than in females (M/F ratio >1.7).
Increased Expression and Altered Functional Activities of Immune Receptors TREM1, PD-L1, and Others on Hematopoietic Progenitor Cells in a Mouse Model of Rheumatoid Arthritis biorxiv.org 2026-06-12 Hematopoietic stem and progenitor cells (HSPCs) sustain the production of hundreds of billions of new cells per day to maintain our blood and immune s
Type I interferon primes the alveolar epithelium to receive reparative signals from tissue-resident macrophages biorxiv.org 2026-06-12 Lung repair in response to viral infection requires integrated communication between epithelial and immune compartments, yet the impact of antiviral m
An investigation of the IL-23/Th17 axis and transcriptomic profiles of T helper subsets in endometriosis biorxiv.org 2026-06-12 Endometriosis (EMS) is a chronic inflammatory disease characterized by ectopic endometrial-like tissue growth and immune dysregulation.
Deficiency of IL-36 receptor antagonist (DITRA) is associated with decreased homoeostatic CCL27 expression leading to heightened dermal inflammation. biorxiv.org 2026-06-12 Deficiency of the Interleukin-36 Receptor antagonist (DITRA) is a rare autoinflammatory condition which commonly manifests as severe, recurrent episod
Cell Cycle Sensing Shapes Human T Cell Fate and Exhaustion Programs biorxiv.org 2026-06-12 Cell cycle (CC) dynamics are reflected in diverse T cell processes such as TCR activation, expansion, contraction, differentiation, senescence, anergy
Trypanosoma brucei infection remodels the uterine immune environment and drives neuroendocrine dysfunction biorxiv.org 2026-06-12 Human African Trypanosomiasis (HAT) or sleeping sickness is a systemic parasitic infection caused by the protozoan parasite Trypanosoma brucei.
MAHLER: Integrating Metadynamics and Inverse Folding to Predict Antibody-Antigen Kinetics biorxiv.org 2026-06-12 Binding kinetics are crucial for antibody function, shaping pharmacokinetics and in vivo efficacy beyond what equilibrium affinity captures.
Sweet interference: oral fermentation volatile confounders in exhaled breath revealed by minimal glucose exposure. biorxiv.org 2026-06-12 Volatile organic compounds (VOCs) in human breath have been explored as non-invasive biomarkers for disease, including respiratory infections and canc
High school science fair: Characterizing student communication and presentation practices and their association with SEF outcomes biorxiv.org 2026-06-12 Obtaining, Evaluating, and Communicating Information is one of the eight Science and Engineering Practices in the National Research Council framework
WNK-SPAK/OSR1 signaling pathway facilitates ictal activity via reduced neuronal chloride extrusion rate biorxiv.org 2026-06-12 Seizures upregulate Na+-K+-2Cl- (NKCC1)-mediated Cl- influx and downregulate K+-Cl- (KCC2)-mediated Cl- efflux via the WNK-SPAK/OSR1 kinases, leading
The Influence of Prior Precision on the Inference of Hidden Causes biorxiv.org 2026-06-12 Perception is widely understood as Bayesian inference, integrating prior expectations with sensory evidence to infer the most probable latent cause of
Spatial collinearity constrains multivariate molecular-enriched network estimation biorxiv.org 2026-06-12 Analyses of neuroimaging data increasingly leverage the distribution of neurotransmitter receptors derived from Positron Emission Tomography (PET) to
Interferon-γ promotes SMAP production by cytotoxic T lymphocytes in a thrombospondin 4 dependent manner biorxiv.org 2026-06-12 Cytotoxic T lymphocytes (CTLs) eliminate infected and cancerous cells by exocytosing cytotoxic granules, either as single-core granules (SCGs) releasi
Antigen Stimulation Reactivates HIV-1 Proviruses Despite Integration in Repressive Chromatin biorxiv.org 2026-06-12 Intact HIV-1 proviruses become progressively enriched in transcriptionally repressive genomic regions during long-term antiretroviral therapy (ART) an
Distinct Programs of Tissue Adaptation Shape Vitreous CD4+ and CD8+ T-cell States in Chronic Uveitis biorxiv.org 2026-06-12 Tissue-resident memory (TRM) T-cells are increasingly recognized as key mediators of chronic autoimmune inflammation, yet their organization and funct
Host and environmental factors differentially affect patterns of diversity in specialist and generalist parasites biorxiv.org 2026-06-12 Aim: Elucidating the mechanisms shaping parasite diversity patterns is critical because parasites encompass about 40% of known species, and are crucia
Genetic Modeling of Dyadic Behavioral Traits: Implications for Estimation and Interpretation of Variance Components biorxiv.org 2026-06-12 Studying the genomic control of dyadic social interactions is gaining traction in animal genetics.
Scaling Across Environments: Temperature and nutrition independently shape the genetics of size plasticity and morphological scaling biorxiv.org 2026-06-12 Across animals, variation in adult body size is accompanied by coordinated variation in the size of individual morphological traits.
Mimosa pudica-derived zinc oxide nanoparticles preserve mesenchymal stromal cell viability, morphology, and osteogenic competence biorxiv.org 2026-06-12 Abstract Introduction: Musculoskeletal disorders remain a major cause of disability worldwide and require non invasive regenerative strategies that su
Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesia biorxiv.org 2026-06-12 Understanding how receptor-level pharmacological modulation reorganizes large-scale brain circuits remains a central challenge in neuropharmacology.