Cannabidiol attenuates chemotherapy-induced peripheral neuropathic pain through a mechanism that requires the enzyme N-acylphosphatidylethanolamine-specific phospholipase D (NAPE-PLD) biorxiv.org 2026-06-12 Cannabidiol (CBD) is a non-psychoactive component of cannabis that has been studied as a potential therapy for chronic pain.
Kombucha-Derived Cellulose Non-wovens: Growth Optimization, Mechanics, and Recycling biorxiv.org 2026-06-12 The environmental impact of synthetic non-woven materials has prompted the search for sustainable and biodegradable alternatives.
A Dual-Locus-Targeting Strategy to Enhance CRISPR/Cas9-mediated CFTR Replacement via Helper-Dependent Adenoviral vector in porcine genome biorxiv.org 2026-06-11 Gene therapy has been the subject of extensive research following the advent of gene-editing technologies.
Divergent activation of the RXFP1 relaxin receptor by protein and small molecule agonists biorxiv.org 2026-06-11 RXFP1 is an unusual G protein-coupled receptor (GPCR) that mediates physiological adaptations to pregnancy and is a therapeutic target due to its bene
DLDN-Bench: A Benchmark Framework for Deep Learning de Novo Peptide Sequencing in Proteomics biorxiv.org 2026-06-11 De novo peptide sequencing is an essential approach for analyzing mass spectrometry data because it enables the identification of novel peptides witho
Mechanisms of viral budding through cellular membranes biorxiv.org 2026-06-11 Budding is a fundamental membrane remodeling process central to many cellular functions and is exploited by numerous enveloped viruses to acquire thei
Covalent Inhibition of New Delhi Metallo-β-Lactamases NDM-1 and NDM-5 by 3-Bromopyruvate biorxiv.org 2026-06-11 Resistance to {beta}-lactam antibiotics, including carbapenems, mediated by metallo-{beta}-lactamases (MBLs), including the New Delhi metallo-{beta}-l
: A standardized bath challenge of Atlantic salmon reveals distinct infection dynamics and mortality across ten HPR-deleted infectious salmon anaemia virus isolates. biorxiv.org 2026-06-11 Infectious salmon anaemia virus with highly polymorphic region deletions (ISAV-HPR{Delta}) is classified as pathogenic, yet field outbreaks display wi
Cross-protection against Bundibugyo by Ebola and Sudan vaccines biorxiv.org 2026-06-11 Ebola outbreaks continue to expand across Central Africa, yet available countermeasures remain limited and virus-specific.
Laboratory adaptation and complete genome assembly of a Beposo, Ghana strain of the human hookworm Necator americanus biorxiv.org 2026-06-11 Laboratory models are invaluable tools for studying parasite biology and pathogenesis, especially for helminth infections.
Infection-specific long-chain fatty acid metabolism as a broad anti-enterovirus target biorxiv.org 2026-06-11 Enteroviruses are arguably the most numerous group of viruses infecting humans.
Plasmid copy numbers reflect distinct evolutionary strategies biorxiv.org 2026-06-11 Different plasmids exist at different copy numbers per cell, and there is an inverse relationship between a plasmid's copy number and its size.
Mutations associated with streptomycin resistance predicted to be highly prevalent and evolvable across bacteria biorxiv.org 2026-06-11 Antimicrobial resistance is an evolutionary response to antimicrobial exposure that has been extensively studied across some bacteria, including patho
Ancient DNA perspectives on North American cervids identify dispersal waves and fluctuations in diversity biorxiv.org 2026-06-11 North American fauna experienced major changes over the last two million years.
The Origin and Evolution of Protein Synthesis: A Co-Adaptation Flexible-Rigid Docking Model Based on First-Principles Reasoning biorxiv.org 2026-06-11 Although the "RNA World" hypothesis suggests that RNA played a crucial role in the origin of life [7], the functional framework of RNA in prebiotic pr
Multimodal phenotyping defines variant-to-function maps for RBM20 in dilated cardiomyopathy biorxiv.org 2026-06-11 Multiplex assays of variant effects have linked thousands of genotypes to fitness effects, yet we lack profound understanding of how variants impact m
Controlling metal-carbonate phase, form, and function through de novo protein design biorxiv.org 2026-06-11 Biomineralization enables living systems to construct hybrid materials by controlling the location, orientation, and polymorph of inorganic crystals w
Sequence-encoded H2A.Z nucleosome dynamics control DNA unwrapping and SUV420H1 recognition biorxiv.org 2026-06-11 H2A.Z and canonical H2A adopt nearly identical nucleosomal folds, yet their distinct chromatin functions are not captured by static structural analysi
Viability of engineered AAVs via protein language models biorxiv.org 2026-06-11 Capsid engineering has greatly improved the performance of recombinant AAV vectors used for gene therapy.
HalluDesign-NA: Extending HalluDesign for De Novo Nucleic Acid Design biorxiv.org 2026-06-11 AlphaFold3 has revolutionized the prediction of biomolecular structures and interactions, including atomic-level modeling of nucleic acids.
Variable ectopic heterochromatin islands provide an alternative route to antifungal heteroresistance in Cryptococcus neoformans biorxiv.org 2026-06-11 The fungal pathogen Cryptococcus neoformans is estimated to cause approximately 180,000 deaths annually, primarily among immunocompromised HIV patient
Phylogenomic description of three novel species of the Microbulbifer genus, phylum Pseudomonadota, isolated from marine sponges and corals biorxiv.org 2026-06-11 Understudied bacterial genera present a dynamic phylogenetic landscape and opportunities for discovering new taxa as more strains are isolated and gen
Virus-grazer interplay enhances virus production, particle aggregation, and trophic efficiency during infection of Prochlorococcus biorxiv.org 2026-06-11 Viruses and grazers are fundamental agents of mortality in the oceans, impacting phytoplankton populations and organic matter cycling.
Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells biorxiv.org 2026-06-11 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets the respiratory epithelium, yet severe disease features diffuse lung in
Morphological and thermoregulatory responses to urbanization in the European garden spider Araneus diadematus. biorxiv.org 2026-06-11 Urbanization creates novel environments that can drive phenotypic and behavioural responses, yet how multiple traits respond across spatial scales rem
Plant MutS Homolog 1 is a mismatch-directed nuclease required for organelle genome maintenance biorxiv.org 2026-06-11 The MSH1 gene in Arabidopsis thaliana (AtMSH1) encodes a modular enzyme that consists of an N-terminal MutS DNA mismatch repair module fused to a C-te
Multimodal PET Defines a Goldilocks Thermal Window for Focused Ultrasound Ablation and Immunotherapy Combinations biorxiv.org 2026-06-11 Background: Thermally ablative focused ultrasound (T-FUS) offers a noninvasive, spatially precise strategy for local tumor destruction, with the added
Topology-aware thermodynamics for DNA probe design under fixed stringency: Retained paired boxes link mismatch placement, nearest-neighbor stability and room-temperature diagnostic specificity biorxiv.org 2026-06-11 DNA probe specificity is usually screened by mismatch number, melting temperature and full-duplex nearest-neighbor free energy.
Isolation and introductions disrupt the homogeneity of Argentine ants in Europe. biorxiv.org 2026-06-11 The introduction of alien species into new habitats stands as a pressing economic and ecological challenge but it is also essential for unveiling evol
inquiSTR: a toolkit for accurate and efficient population-scale tandem repeat genotyping and analysis biorxiv.org 2026-06-11 Tandem repeats are highly mutable genomic elements linked to human traits and diseases.