α-Synuclein strain homogeneity in multiple system atrophy clinical subtypes biorxiv.org 2026-06-10 Conformationally distinct 'strains' of -synuclein aggregates are believed to contribute to the clinical and pathological diversity observed among synu
Pathology in resected areas of FDG PET hypometabolism in pediatric epilepsy patients with focal cortical dysplasia biorxiv.org 2026-06-10 Introduction: [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) frequently reveals hypometabolism extending beyond the epileptogenic zone
Lineage-specific chromatin poising enforced by ETS-IRF composite elements determines the divergent interferon responses of plasmacytoid dendritic cells and epithelial cells biorxiv.org 2026-06-10 Plasmacytoid dendritic cells (pDCs) produce robust type I interferons (IFN-I) within hours of viral sensing, while epithelial cells at mucosal surface
Viral load-driven systemic immune exhaustion is an enabler of antibody breadth in HIV infection biorxiv.org 2026-06-10 A broadly neutralizing response to a human immunodeficiency virus (HIV) vaccine is a major goal of the field, yet the determinants of antibody breadth
Circadian Clock Control of Muscle Stem Cells Through Temporal Coordination of Notch and Wnt Signaling biorxiv.org 2026-06-10 The circadian clock regulates stem cell responses during tissue remodeling and repair.
Hemoglobin C is prone to oxidative denaturation, resulting in red blood cell membrane damage in HbSC disease biorxiv.org 2026-06-10 Sickle-hemoglobin-C (HbSC) sickle cell disease is characterized by RBC dehydration (xerocytosis), which promotes polymerization of HbS.
Staurosporine drives non-canonical melanocyte maturation by coupling β-catenin signaling to actin-dependent dendrite remodeling biorxiv.org 2026-06-10 Skin pigmentation relies on the coordinated regulation of melanin production and dendritic morphology to ensure effective pigment distribution.
Flight performance of the highly invasive box tree moth Cydalima perspectalis (Lepidoptera: Crambidae) biorxiv.org 2026-06-10 The multivoltine non-native box tree moth, Cydalima perspectalis (Lepidoptera: Crambidae), was accidentally introduced in several continents and exhib
Outbred Drosophila populations reveal diet-dependent genetic effects on development time biorxiv.org 2026-06-10 Metabolic effects of genetic variation often depend on diet, yet the loci underlying diet-dependent developmental responses remain incompletely define
Gene loss under constant cold reveals "natural knockout" loci in Antarctic notothenioid fishes biorxiv.org 2026-06-10 Abstract Background Gene loss is a major but often underappreciated mode of genome evolution.
The Conductome: A Bayesian Classifier Approach to Predicting and Understanding Behaviour biorxiv.org 2026-06-10 Predicting and understanding behaviour is a primary objective of many disciplines, especially human behaviour, as it is the cause of many of the world
Electroadhesion of polymer networks by polycation interfacial bridging: sticky electrophoresis, ionic complexation, and chain entanglement biorxiv.org 2026-06-10 An e-GLUE is a polymer network containing interpenetrating polycations, which can bond the anionic network of mucosa through interfacial polycation br
Biocompatible designated Resin-3D-printed polymers exhibit reproductive toxicity prevented by Parylene-C biorxiv.org 2026-06-10 Resin three-dimensional (3D) printing is an increasingly popular manufacturing and prototyping method used to create microphysiological systems (MPS),
SPARQ-MI leverages end-to-end spatial single-cell analysis of the tumor microenvironment biorxiv.org 2026-06-10 Detailed spatial analysis of the tumor micro-environment (TME) through multiplexed fluorescence imaging requires quantitative image-processing and dat
Comparative Molecular Dynamics Characterization of Hair Keratin Unfolding Mechanics biorxiv.org 2026-06-10 Keratin proteins are fundamental structural components of hair fibers, contributing to their mechanical resilience, elasticity, and fracture resistanc
Dietary omega-6 arachidonic acid and omega-3 docosahexaenoic acid supplementation differentially impact skeletal muscle inflammaging in mice biorxiv.org 2026-06-10 Aging is associated with a gradual and progressive decline in skeletal muscle mass and strength known as sarcopenia, which has been attributed to chro
Neural Innervation Invigorates Yolk Sac Biological Functions beyond Nutrient Reservoir during Zebrafish Embryo Development biorxiv.org 2026-06-10 The zebrafish yolk sac (YS) is traditionally viewed as a nutrient reservoir.
Neuro-glial lipid imbalance in a Drosophila model of Amyotrophic Lateral Sclerosis 8 biorxiv.org 2026-06-10 Membrane Contact sites (MCS) have emerged as physiologically relevant zones that coordinate inter-organelle communication and cellular function.
Use of a plasmid containing a dual gene reporter system to assess the cell hydrophobicity of Listeria monocytogenes biorxiv.org 2026-06-10 Listeria monocytogenes causes listeriosis in humans and animals and contaminates prepared food by attaching to food processing environments.
SPAFESTWDILK, a plant-derived dodecapeptide from Zingiber officinale, as a predicted inhibitor of the MDM2-p53 interaction: computational discovery and multi-method evaluation biorxiv.org 2026-06-10 The MDM2-p53 protein-protein interaction is a validated oncology target, yet no food-derived linear peptide has been documented to engage the canonica
Active Learning-Guided Peptide Design for Modulating Condensate Properties upon Recruitment biorxiv.org 2026-06-10 The physical properties of biomolecular condensates, which form through phase separation, are central to their organisation and function and are incre
Estrogen-Deficiency Degrades Left Ventricular Diastolic Function and Energy Metabolism in Hypertensive Female Mice biorxiv.org 2026-06-10 Aims: Heart failure (HF) due to diastolic dysfunction (DD) but normal left ventricular (LV) ejection fraction (EF) is termed HF with preserved EF (HFp
Capsinoids (non-pungent TRPV1 agonists) promote mild hypothermia and improved outcome following stroke in aged mice biorxiv.org 2026-06-10 Background and Purpose: Mild hypothermia provides potent neuroprotection in experimental ischemic stroke, however, its implementation in awake stroke
A microbial-sensory axis drives Pseudomonas aeruginosa-induced mechanical itch biorxiv.org 2026-06-10 Cutaneous bacterial infections frequently elicit severe pruritus, prominently featuring alloknesis, a pathological state where innocuous touch provoke
Cortical E-fields of deep brain stimulation in Parkinson's disease patients exceed typical E-field magnitudes of transcranial electrical stimulation biorxiv.org 2026-06-10 Background: Deep brain stimulation (DBS) is an established and effective intervention for Parkinson's disease.
Generalisable signatures of anaesthesia in the large-scale functional organisation of the marmoset brain biorxiv.org 2026-06-10 How the activity and connectivity of the brain support consciousness remains a central question in neuroscience.
Disentangling mechanisms of single-cell growth rate fluctuations biorxiv.org 2026-06-10 Single-cell growth rates fluctuate across time and generations, but identifying the biological origin of this variability is difficult because growth
Tagging C. elegans septins disrupts cytoskeletal scaffolding but not post-embryonic roles biorxiv.org 2026-06-10 Septins are conserved polymer-forming proteins that scaffold the actomyosin cytoskeleton, its regulators, and other factors to cellular membranes.
In situ molecular architecture of PML bodies reveals open-state columnar trinucleosome assemblies within a porous, chromatin-permissive interior biorxiv.org 2026-06-10 Genome function in the nucleus is organised through membrane-less compartments enriched with specific proteins and nucleic acids.
Lipid transfer protein ORP3 mediates lysosomal repair via LC3B and ubiquitin-TAK1-p38 biorxiv.org 2026-06-10 Lysosomal membrane damage triggers a multi-stage repair response essential for cellular homeostasis.