Dynamics of phosphofructokinase condensation are regulated by metabolic and redox cues biorxiv.org 2026-06-10 Condensation of phosphofructokinase, the rate-limiting enzyme of glycolysis, into granules has been observed across species and in various stress cond
Senescent and reactive astrocytes display distinct expression profiles and divergent functional capacities. biorxiv.org 2026-06-10 Astrocytes assume multiple phenotypes in the brain in response to stress, injury, inflammation, and aging.
Structural Mechanism and Cellular Restriction of Tau Seeding from Endolysosomes biorxiv.org 2026-06-10 The prion-like spread of tau from cell to cell in the central nervous system involves escape from the endolysosomal network, which is counteracted by
Mitochondrial-derived compartments buffer outer membrane protein load during acute mitochondrial adaptation biorxiv.org 2026-06-10 Cells undergoing metabolic transitions rapidly remodel mitochondria through coordinated expansion and reorganization of the mitochondrial proteome.
Mitochondrial degradation of metallothionein enables local zinc mobilization during zinc limitation biorxiv.org 2026-06-10 Zinc is an essential structural and enzymatic cofactor for roughly 10% of proteins, including transcription factors, metabolic enzymes, and cytoskelet
Stretched Exponential Modeling Reveals Drug-Specific Kinetics in Human Engineered Skeletal Muscle biorxiv.org 2026-06-10 Understanding muscle tissue is key not only for advancing our knowledge in biophysical function of the human body, but can also open new paths to bett
Multi-timescale learning signals in Drosophila dopaminergic neurons biorxiv.org 2026-06-10 Learning often requires inference over hidden task structure, including features that predict outcomes.
4 Phenylbutyrate Plus Gene augmentation: A dual therapy To Rescue of SLC6A1 Variant Associated Developmental And Epileptic Encephalopathy biorxiv.org 2026-06-10 Background: Pathogenic variants in SLC6A1, which encodes the {gamma}-aminobutyric acid (GABA) transporter GAT-1, cause developmental and epileptic enc
In-vitro evaluation of Ozenoxacin and other Antibiotics against Staphylococcus aureus and Streptococcus pyogenes isolated from Skin and Soft Tissue Infections biorxiv.org 2026-06-10 Staphylococcus aureus and Streptococcus pyogenes are major causative bacteria responsible for skin and soft-tissue infections (SSTIs) such as impetigo
Subtype-specific differences in susceptibility to monoclonal antibodies and vaccines among contemporary RSV-A and RSV-B isolates biorxiv.org 2026-06-10 Respiratory syncytial virus (RSV) continues to circulate at high levels despite the introduction of new monoclonal antibodies (mAbs) and vaccines targ
M6A-modified circEZH2 Protects Endothelial Cells from Senescence and Suppresses Atherosclerosis by Stabilizing ZNF326 biorxiv.org 2026-06-10 Objective: Endothelial cell senescence induces endothelial dysfunction, thereby contributing to atherosclerosis progression.
The engulfment receptor CED-1/MEGF10 activates the GPCR LAT-1/ADGRL3 for apoptotic cell degradation biorxiv.org 2026-06-10 Efferocytosis, the clearance of apoptotic cells, is crucial for tissue homeostasis, inflammation suppression, and repair.
Ca2+-activated CKL3 phosphorylates nucleoporin 58 to reprogram nuclear transport and execute effector-triggered immunity biorxiv.org 2026-06-10 Recognition of pathogen effectors by nucleotide-binding leucine-rich repeat receptors (NLRs) activates effector-triggered immunity (ETI) in plants thr
VIRP1 bromodomain shapes nuclear condensate formation and has a positive effect on PSTVd accumulation biorxiv.org 2026-06-10 -Viroids are small, non-coding RNAs that rely on host proteins for replication, intracellular trafficking and systemic movement.
Clade III HIPP genes encode plasmodesmata-targeted proteins with pleiotropic functions in regulating plant development. biorxiv.org 2026-06-10 Heavy metal-associated isoprenylated plant proteins (HIPPs) are encoded by large gene families, which have diversified specifically in vascular plants
Immunoengineered Chitosanase-Produced Chitosan Oligomers for Elevating Plant Resistance to Viral Infection biorxiv.org 2026-06-10 Chitooligomers can act as plant biostimulants or biopesticides, but current chitosan-based agro-biologics often lack sufficient efficacy.
Evaluating crop models for future climate scenarios: wheat yield predictions using APSIM and STICS under combined CO2, warming, and water deficit conditions biorxiv.org 2026-06-10 Crop models are essential for predicting climate change impacts on agriculture, yet their validation under multi-stress conditions remains limited.
The coordination between xylem and bark hydraulics in temperate Rosaceae species biorxiv.org 2026-06-10 Xylem and bark properties influence tree growth and drought resistance, yet their functional coordination and their environmental drivers remain uncle
Rational design of T-DNA vectors enables predictable, single-copy integration in Arabidopsis thaliana biorxiv.org 2026-06-10 Agrobacterium-mediated transformation is the dominant method for plant transgenesis, yet it frequently produces multi-copy, structurally complex T-DNA
Dual Knockout of StAMY23 and StVINV Improves Postharvest Storage Traits in Potato biorxiv.org 2026-06-10 Starch is the primary carbohydrate reserve in potato (Solanum tuberosum L.) tubers and a critical determinant of their industrial value.
The plant immune receptor LORE binds agonistic and antagonistic 3-hydroxy fatty acid ligands via a dynamic loop in its G-type lectin domain biorxiv.org 2026-06-10 The Arabidopsis thaliana S-domain receptor kinase LORE senses bacterial medium-chain 3-hydroxy fatty acids (mc-3-OH-FAs) as microbe-associated molecul
A Neuronal Gene Expression Program Underlying Sustained Network Activity biorxiv.org 2026-06-10 Neurons function within interconnected networks and must continuously adjust their firing properties to maintain stable network activity.
The Critical Period Microbiota Shape Brain Plasticity biorxiv.org 2026-06-10 The gut microbiota is increasingly recognized as a regulator of brain function, yet its role in experience-dependent plasticity during postnatal devel
Deafness and sign language experience shift visual category representations biorxiv.org 2026-06-10 Childhood visual experiences shape our ability to rapidly recognize faces and objects.
Hearing Lips and Seeing Voices After Fifty Years: A Large-Scale McGurk Illusion Dataset for Audiovisual Speech Research biorxiv.org 2026-06-10 Efficient face-to-face communication relies on the integration of auditory speech and visual articulatory signals.
APOE4 genotype, blood-brain barrier leakage and ischaemic stroke subtype and location biorxiv.org 2026-06-10 Background: Apolipoprotein E (APOE) has been implicated in blood-brain barrier (BBB) dysfunction and may influence ischaemic cerebrovascular disease a
Myofibroblast- specific autophagy drives cyst growth in autosomal dominant polycystic kidney disease biorxiv.org 2026-06-09 Background: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst expansion, fibrosis and inflammation, leading to
Perturbing glycosylphosphatidylinositol (GPI)-anchor biosynthesis alters cell wall architecture and modulates fungal morphology biorxiv.org 2026-06-09 Filamentous fungi are widely used as expression hosts for industrial protein production.
Accurate de novo design of peptides from programming biophysical landscape biorxiv.org 2026-06-09 Peptides regulate virtually every cellular process and emerge as transformative modalities in bioengineering and therapeutics.
Deciphering the limitations of immortalized hepatocyte cell lines for the study of liver cis-regulatory elements biorxiv.org 2026-06-09 Immortalized cell lines are widely used in biological research despite their known differences from their tissues and cell types of origin.