Low-dimensional Neural Codes Suppress Neuronal Noise and Extend the Working Memory Duration biorxiv.org 2026-06-09 Neurons are noisy computational substrates, yet large neural populations achieve reliable computation.
Connectivity Logic of Dendritic Spines in Cortex: Increased Inputs and Ensemble Formation biorxiv.org 2026-06-09 Dendritic spines, small protrusions covering the dendrites of most neurons, are fundamental elements of synaptic connectivity, yet their network-level
Stable Vesicle-Associated BDNF from Embryonic and Young Cortical Extracellular Vesicles biorxiv.org 2026-06-09 In this work we show that small extracellular vesicles (sEVs) from embryonic mouse cortex or from cultured embryonic cortical neurons contain high lev
Prenatal exposure to maternal stress drives sex-specific neurodevelopmental disruptions in the fetal hypothalamus biorxiv.org 2026-06-09 The hypothalamus plays a central role in integrating physiological stressors to maintain homeostasis, yet how fetal neurodevelopment in the hypothalam
Towards coevolution-aware ancestral sequence reconstruction biorxiv.org 2026-06-09 Ancestral sequence reconstruction (ASR) is a powerful approach for studying molecular evolution and the emergence of protein function.
Leptin Drives Osteoarthritis Pain Through Sensory Neuron Reprogramming Independent of Cartilage Signaling biorxiv.org 2026-06-09 Objective: Pain in osteoarthritis (OA) is often discordant with structural joint damage, particularly in obesity-associated OA, where adipose-derived
PanKbase Integrated Single-Cell Map: A Comprehensive Atlas of Human Pancreatic Islets biorxiv.org 2026-06-09 Abstract Aims/hypothesis Single-cell RNA sequencing (scRNA-seq) of pancreatic islet tissue is a powerful tool for investigating Type 1 Diabetes (T1D).
Organ on chip model of respiratory vascular interactions under COPD relevant oxidative stress biorxiv.org 2026-06-09 Oxidative stress-induced airway injury contributes to chronic obstructive pulmonary disease (COPD).
Evaluating agentic AI for biological discovery in autonomous and copilot settings biorxiv.org 2026-06-09 Advances in large language models (LLMs)-based artificial intelligence (AI) agents have improved their ability to execute structured analytical workfl
Complex-phase stochastic modeling of mitochondrial heteroplasmy biorxiv.org 2026-06-09 Mitochondrial heteroplasmy the coexistence of both wild-type and mutant copies of mitochondrial DNA ( mtDNA ) within a cell is a key factor in the pat
TaxoFormer: Hierarchical Transformer for Predicting the Full Taxonomic Lineage of Protein Sequences biorxiv.org 2026-06-09 Predicting labels in massive, hierarchically structured output spaces is a core challenge in machine learning.
Posture and support geometry, rather than body size, dictate lateral dynamic stability in walking mammalian quadrupeds biorxiv.org 2026-06-09 Body size and limb posture vary widely across mammals and are expected to shape locomotor stability, yet direct comparative evidence remains limited.
Immunomodulatory Effects of Insulin-Derived Fibrils from Infusion Pumps: Role of Phenolic Preservatives in Macrophage Activation biorxiv.org 2026-06-09 Background: Protein fibrillation represents a critical challenge in therapeutic insulin delivery, yet the structural determinants and immunological co
SHERLOC: An interpretable deep learning model for longitudinal circulating tumor DNA data in survival analysis biorxiv.org 2026-06-09 Longitudinal circulating tumor DNA (ctDNA) measurements offer a noninvasive means to monitor treatment response, but clinical trial data present subst
Chronic Stress Exacerbates Long-term Microvascular Network Dysfunction Following Brain Trauma biorxiv.org 2026-06-09 Background: Preexisting factors are among the strongest predictors of recovery following traumatic brain injury (TBI), with chronic stress closely ass
Lineage tracing and live-cell imaging reveal that NeuroD1 does not reprogram microglia into neurons biorxiv.org 2026-06-09 Induction of glia-to-neuron conversion is a promising regenerative strategy for treating brain injuries and neurodegenerative diseases.
Otoprotective effect of MnTBAP in cisplatin-induced hearing loss biorxiv.org 2026-06-09 Objective: Cisplatin, a life-saving chemotherapeutic drug, causes ototoxicity.
Robust learning-driven structural and functional plasticity of spines in the mature mouse cortex biorxiv.org 2026-06-09 Spines in the adult cortex are thought to be highly stable, and that their capacity for modest remodeling supports learning.
A Low-Cost, High-Throughput Design-Build-Test Pipeline for Engineering Genetic Systems: Stress Testing with Complex Structural Proteins biorxiv.org 2026-06-09 Genetic systems engineering is constrained by high DNA synthesis costs, assembly inefficiencies, and challenges in expressing complex proteins.
Structure and functional diversity of antibodies targeting the P. falciparum circumsporozoite protein C-terminal domain biorxiv.org 2026-06-08 The Plasmodium falciparum circumsporozoite protein (PfCSP) is the major surface antigen on Pf sporozoites.
Dietary fiber selectively regulates intestinal persistence of probiotic bifidobacteria biorxiv.org 2026-06-08 Bifidobacteria dominate the gut microbiota of breast-fed infants, and are strongly associated with human health, including immune regulation, coloniza
Mapping Genome-wide Transcription Factor Binding Sites in two Rhodanobacter strains Isolated from Extreme Environments biorxiv.org 2026-06-08 Identification of target genes for bacterial transcription factors (TFs) provide a deeper understanding of bacterial response to environmental conditi
A-to-I mRNA editing recodes CqsA and affects T6SS-mediated killing in Vibrio biorxiv.org 2026-06-08 Adenosine-to-inosine (A-to-I) RNA editing alters genetic information post-transcriptionally, yet its ecological and evolutionary significance in bacte
Light-dependent and predator inducible aldehyde synthesis in Prochlorococcus for specific defense against Uronema biorxiv.org 2026-06-08 Cyanobacteria as a primary producer provide energy and carbon sources for the marine food web, of which predation-interactions play central roles in r
Redox stress agents strongly enhance mutagenesis during horizontal gene transfer in bacteria and leave distinct mutational and metabolic footprints biorxiv.org 2026-06-08 Redox stress induces DNA mutations that contribute to chronic conditions affecting human health and to the emergence of antibiotic resistance.
Quantitative profiling of JMJD6-catalysed lysine hydroxylation reveals residue-dependent oxygen sensitivity biorxiv.org 2026-06-08 Lysine hydroxylation is increasingly recognised as a widespread post-translational modification in human cells, with more than 100 modified sites iden
One-pot lactic acid production from rice straw: A consolidated bioprocess with enzymatic pretreatment-saccharification and Microbial co-fermentation biorxiv.org 2026-06-08 Global demand for platform chemicals and biomaterials urges us to seek sustainable strategies along with waste valorization to produce lactic acid (LA
Cell-Dense Bioink Design for Xolography: Coupling Refractive Index-Matching with Increased Photoreactivity biorxiv.org 2026-06-08 Bioxolography enables high-resolution fabrication of geometrically complex, cell-laden constructs for tissue engineering.
ProtGPT3: an Open-source family of Promptable and Aligned Protein Language Models biorxiv.org 2026-06-08 Generative protein language models (pLMs) enable exploration of vast sequence spaces for protein design, but reliably controlling generation toward de
TRACEY: an updated resource for SNARE protein domain annotation with improved HMMs and expanded sequence coverage biorxiv.org 2026-06-08 Motivation: SNARE proteins catalyse membrane fusion across the eukaryotic endomembrane system, from synaptic vesicle exocytosis to intracellular traff