In vivo functional classification of PTEN variants reveals context-dependent oncogenicity and interindividual variability biorxiv.org 2026-06-08 Gene variants, secondary mutations, and stochastic individual variability complicate cancer diagnosis, prognosis, and treatments.
A Drug-Target Specificity Foundation Model for Off-target Prediction, Repurposing, and Generative Design biorxiv.org 2026-06-08 Molecular recognition - which small molecule binds which protein, and with what selectivity - governs the efficacy, safety, and discovery of every the
Salivary microRNA Profiling of Long COVID Subjects Reveals Host-Encoded Regulators of Inflammation and Viral Persistence biorxiv.org 2026-06-08 Periodontal disease (PD) and SARS-CoV-2 infection converge upon shared immunoinflammatory axes, yet the molecular mechanisms underpinning their interp
Cryo-EM provides insight into how the Staphylococcus aureus IsdH receptor removes hemin from the hemoglobin:haptoglobin complex biorxiv.org 2026-06-08 Staphylococcus aureus extracts hemin from human hemoglobin (Hb) to overcome host-imposed iron limitation.
Genetic basis of glycine and L-serine toxicity in Staphylococcus aureus and the case for glycine as an antibiotic adjuvant biorxiv.org 2026-06-08 The toxicity of the amino acids glycine and L-serine at high concentrations in bacteria was discovered decades ago.
Epigenetic Patterns of Xylanibacter ruminicola in Bovine Rumen Across Seasons and Pregnancy biorxiv.org 2026-06-08 Ruminants obtain nutrients through the microbial fermentation of plant material in the rumen.
Diet-dependent microbiota and diet-independent immunometabolic responses to probiotic supplementation in broiler chickens biorxiv.org 2026-06-08 Probiotics are widely used in food animal production to support gut health and immune function, but the indicators of probiotic efficacy and the condi
Deletion of 29 cell death-inducing proteins and phytotoxin biosynthetic genes does not completely abolish virulence of Botrytis cinerea biorxiv.org 2026-06-08 Botrytis cinerea is a necrotrophic plant pathogen with an extremely wide host range.
Nanopore Direct RNA Sequencing Enables Reproducible, Site-Resolved Pseudouridine Quantification in Human Ribosomal RNA biorxiv.org 2026-06-08 Pseudouridine is the most abundant post-transcriptional modification in human ribosomal RNA, with over 110 annotated sites and variable stoichiometry
A C-terminal Processing Protease Implicated in Flagellin Turnover and Developmental Progression in a Bacterial Predator biorxiv.org 2026-06-08 Carboxy-terminal processing proteases (CTPs) are widely conserved bacterial proteases implicated in protein maturation, quality control, and stress re
Resident soil microbial diversity and urea amendment legacy interact to shape the composition and expression of a surface film-forming soil inoculant biorxiv.org 2026-06-08 Soil microbial inoculants have the potential to improve crop yield, enhance agricultural sustainability, and support soil restoration, but they often
Detection and genomic characterisation of a novel hantavirus in Australian dolphins biorxiv.org 2026-06-08 We report the detection of a novel hantavirus in the lung tissue of two diseased Australian dolphins with histopathological changes.
Topic modeling reveals thermally partitioned and taxonomically distinct microbial subcommunities across prokaryotes and phytoplankton in the Laurentian Great Lakes biorxiv.org 2026-06-08 Identifying discrete microbial assemblages and their environmental drivers across multiple biological fractions simultaneously remains a central chall
Comparative genomics reveals extensive genomic conservation and limited microdiversification among Xenorhabdus bovienii isolates recovered from a single Steinernema feltiae isolation event. biorxiv.org 2026-06-08 Xenorhabdus bovienii is a symbiotic bacterium associated with entomopathogenic nematodes of the genus Steinernema.
Targeting an allosteric binding site in the citrate transporter NaCT (SLC13A5) biorxiv.org 2026-06-08 The Na+-dependent citrate transporter NaCT (SLC13A5) is a key regulator of citrate homeostasis and has emerged as a therapeutic target for metabolic a
Antidepressant fluoxetine engages astrocytic cAMP via purinergic signalling biorxiv.org 2026-06-08 The use of selective serotonin reuptake inhibitors (SSRIs), the first-line treatment for depression, has increased by about 50% over the past decade,
Neurodevelopmental Inequality arising from Early Childhood Stunting: Evidences from Brain Connectivity biorxiv.org 2026-06-08 Early childhood stunting (ECS) affects millions of children globally and conjectured to result in suboptimal brain and cognitive development later in
Choriodecidual Ureaplasma parvum infection induces fetal lung inflammation prior to intra-amniotic infection in a nonhuman primate model biorxiv.org 2026-06-09 Preterm birth before 28 weeks remains a leading cause of neonatal mortality and long-term morbidity.
Programmable Assembly of DNA Tetrahedra Bearing Atomically Precise Gold Nanoclusters: Stoichiometric Control and Molecular-Level Characterization biorxiv.org 2026-06-09 Atomically precise gold nanoclusters (AuNCs) are ultra-small particles composed of ten to hundreds gold atoms and exhibit unique photophysical propert
<i>In situ</i> cell condensation-based cartilage tissue engineering via immediately implantable high-density stem cell core and rapidly degradable shell microgels biorxiv.org
Population-level antagonism between FGF and BMP signaling steers mesoderm differentiation in embryonic stem cells biorxiv.org
Multi-site Cleavage of Amyloid-β by a Minimal 5-mer Catalytic Peptide: Mimicking Serine Protease Activity via Dynamic Substrate-Induced Anchoring biorxiv.org 2026-06-08 The development of small synthetic catalytic peptides, or "catalytides," offers a promising therapeutic strategy for the targeted degradation of amylo
Distinct Neural Systems Supporting Afferent and Efferent Autonomic Activity biorxiv.org 2026-06-08 Numerous studies have revealed neural correlates of autonomic activity.
Batch Effect Correction for Neuroimaging Data with Heterogeneous Spatial Correlations biorxiv.org 2026-06-08 Magnetic resonance imaging scans are effective tools for unveiling brain structures and understanding pathology for complex neurodevelopmental and agi
Comparative Evaluation of Deep Generative Models for Capturing Topological Features in Brain Structural Connectivity biorxiv.org 2026-06-08 Structural connectivity (SC) data are crucial for brain network analysis, but SC-based machine learning often suffers from limited data availability,
Butyrate preserves cardiac health during aging biorxiv.org 2026-06-08 Aging promotes left ventricular hypertrophic remodeling and diastolic dysfunction, yet interventions that preserve cardiac function when initiated lat
A Hierarchical Bayesian Agent Based Model for Binary Spatio-Temporal Spread: Theory, PDE Scaling Limit, and an Application to Predator Prey Cycles biorxiv.org 2026-06-08 We describe a statistical agent based model (SABM) for binary spatio-temporal data in which the occupancy of each cell evolves as a Bernoulli mixture
Complementary Insights from Environmental DNA and Environmental RNA Metabarcoding for Marine Biodiversity Assessment Around San Andres Island, Colombia biorxiv.org 2026-06-08 Environmental DNA (eDNA) metabarcoding has become a cornerstone of marine biodiversity monitoring, yet it recovers genetic material irrespective of or
Decoding the Conformational Dynamics and Hyperactivity of Histone H3K36 N-Methyltransferase in Oncogenic Mutations via tICA and Markov State Modeling biorxiv.org 2026-06-08 NSD2 is a histone methyltransferase that modifies lysine 36 in histone H3 (H3K36), playing a central role in chromatin organization and transcriptiona
Miniaturized subcutaneous cellular implants for sustained therapeutic protein delivery in resource-limited settings biorxiv.org 2026-06-08 Cell encapsulation offers a promising strategy for sustained therapeutic protein delivery, obviating the need for repeated injections.