Scalable generation of pure CD103⁺ cDC1 from iDC1 cultures biorxiv.org 2026-06-09 Conventional type 1 dendritic cells (cDC1) specialize in cross-presentation and interleukin-12 production and are critical for immunity against intrac
Quantifying annotation-stratified pleiotropy and co-polygenicity between complex traits biorxiv.org 2026-06-09 Understanding shared genetic architecture is essential to interpreting disease comorbidities and trait correlations.
A Facile and Versatile Technique for Creating Antifibrotic Coatings on Biomedical Implants biorxiv.org 2026-06-09 Foreign body response is a common yet serious challenge for biomedical implants.
Fluctuating DNA methylation sites encode colorectal tumour growth history biorxiv.org 2026-06-09 Determining the nature of human tumour growth is challenging given the impracticality of obtaining detailed data across time.
Individual, behavioural, and environmental determinants of personal light exposure in daily life: A multi-country wearable and experience-sampling study biorxiv.org 2026-06-09 Personal light exposure is a modifiable determinant of circadian and neurobehavioural health, yet its everyday structure across populations remains po
Antifungal tolerance and resistance dynamics depend on infection load, drug treatment, and host innate immunity biorxiv.org 2026-06-09 Fungi contribute substantially to the global antimicrobial resistance crisis.
Purinergic signaling disrupts emergent patterns of multicellular coordination in basal Xenobots. biorxiv.org 2026-06-09 The ability of self-organizing systems to display emergent, adaptive capabilities is a fundamental feature of biological life.
Spatiotemporal unfolding of prefrontal neural response divergence in adolescent depression during naturalistic experience biorxiv.org 2026-06-09 Depression alters how emotional experience is interpreted and regulated, yet how depression-related neural divergence unfolds during ongoing experienc
LIN-44/Wnt controls developmental neurite pruning via UNC-43/CaMKII and PKC-2/PKC in C. elegans biorxiv.org 2026-06-09 During development, many neurons prune their neurites.
Beyond the Forest and the Trees: Overlooking the Overlooked Terrain of Neural State Dynamics biorxiv.org 2026-06-09 State-transition approaches, including EEG microstate analysis and related fMRI methods such as hidden Markov models (HMMs) and co-activation pattern
Blood-brain barrier model architecture shapes peripheral immune cell trafficking in Parkinson's disease biorxiv.org 2026-06-09 Parkinson's disease (PD) is a neurodegenerative disorder traditionally characterized by dopaminergic neuron loss in the substantial nigra pars compact
Quantitative determination of longitudinal CNS cholesterol loss during myelin damage and repair biorxiv.org 2026-06-09 Cholesterol in the central nervous system (CNS) is largely unesterified (>99%) and is predominantly present in the myelin sheath (~70% of total CNS
Evidence for strong interplay between the nucleotide and base excision repair pathways in D. radiodurans biorxiv.org 2026-06-09 Deinococcus radiodurans harbors a largely classical bacterial DNA repair machinery yet displays exceptional resistance to ultra-violet and ionizing ra
Human Osteochondral Granular Extracellular Matrix (gECM) Hydrogels Drive Tissue-Specific Composition and Mechanics biorxiv.org 2026-06-09 Osteochondral defects remain a major clinical challenge due to the limited regenerative capacity of cartilage and the complexity of the osteochondral
PRIME: scalable, robust inference of mechanistic cell states from multimodal single-cell counts via probability generating functions biorxiv.org 2026-06-09 Single-cell multiomic technologies can now quantify complementary RNA species within the same cell, creating an opportunity to move beyond descriptive
Untargeted cord blood metabolomics reveals altered lipid metabolism in neonates with gastroschisis biorxiv.org 2026-06-09 Gastroschisis is a congenital abdominal wall defect in which fetal intestines herniate into the amniotic cavity.
Organizing principles in the Nitrogen-Carbon Landscape of Marine Heterotrophic Bacteria biorxiv.org 2026-06-09 Marine microbes metabolize a wide range of carbon and nitrogen sources, shaping global biogeochemical cycles.
Auditory Working Memory and Sound Segregation Ability Predict Speech-in-Noise in Adult Cochlear Implant Users biorxiv.org 2026-06-09 Abstract Objectives: Outcomes following cochlear implantation vary substantially across adult recipients, and the cognitive and perceptual factors con
Chromatic topological mapping reveals organelle-specific spatial organization within microglia biorxiv.org 2026-06-09 In branched cells, including neurons and glia, intracellular organelles are distributed across complex cellular arbors where their spatial arrangement
Foveal vision in fast-flying birds hunting on the wing biorxiv.org 2026-06-09 Processing rapid motion while maintaining high spatial acuity is a fundamental evolutionary challenge for the vertebrate visual system.
Regional specificity of neuronal cell types, functional connectivity, and cell type-specific correlation to brain disorders in the human ventral tegmental area biorxiv.org 2026-06-09 The ventral tegmental area (VTA) in the midbrain is a key reward system hub associated with multiple brain disorders.
Modulation index-based phase-amplitude coupling does not encode temporal polarity biorxiv.org 2026-06-09 Background: Phase-amplitude coupling (PAC) is widely used to quantify interactions between neural oscillations across timescales and is often interpre
Preserved self-other integration during social decision making among individuals with elevated autistic traits biorxiv.org 2026-06-09 Autistic people can find social interactions difficult to navigate, traditionally attributed to difficulties in taking others' perspectives.
PINK1 loss in astrocytes triggers inflammatory dysfunction and neuronal death biorxiv.org 2026-06-09 Genetic loss of the mitochondrial control enzyme PINK1 leads to Parkinson's disease, characterized by dopaminergic neuron degeneration and neuroinflam
Adipose tissue as a site of immune activation and dysfunction in individuals with obesity and asthma biorxiv.org 2026-06-09 Obesity increases local inflammatory responses in adipose tissue.
Soluble Urokinase Plasminogen Activator Receptor Primes Macrophages and Worsens Heart Failure with Preserved Ejection Fraction biorxiv.org 2026-06-09 Background. Heart failure with preserved ejection fraction (HFpEF) is a systemic inflammatory syndrome with few effective therapies.
Two melanic pigment patterns are associated with a sex chromosome-linked oncogene in the mountain swordtail Xiphophorus nezahualcoyotl biorxiv.org 2026-06-09 Sex-linked traits are widespread, but their genetic architecture has been challenging to characterize, due in part to the repetitive and structurally
Prefrontal cortical pathways mediating cognitive control enhancement from internal capsule stimulation biorxiv.org 2026-06-09 Background: Deep brain stimulation (DBS) targeting the ventral internal capsule/ventral striatum (VCVS) is an effective treatment for several psychiat
What can a neuron compute biorxiv.org 2026-06-09 Cortical pyramidal neurons possess elaborate dendritic trees with diverse nonlinear membrane conductances and thousands of plastic synapses, suggestin
CRISPR-mediated Stxbp1 gene activation ameliorates epileptic and aggressive phenotypes in Stxbp1-haploinsufficient mice biorxiv.org 2026-06-09 Mutations in the syntaxin-binding protein 1 (STXBP1) gene, which encodes the presynaptic protein Munc18-1, cause a spectrum of severe epileptic enceph