Whole genome sequencing and variant discovery in 344 global grasspea (Lathyrus sativus L.) lines biorxiv.org 2026-06-09 The rapid expansion of genomic data resources for major crops is opening new options for crop improvement, while resources for most underutilised crop
Discovery of a novel dehalogenase from Achromobacter mucicolens for PFAS defluorination biorxiv.org 2026-06-09 Here, we report the purification and characterization of a haloacid dehalogenase type II (HAD-II) enzyme capable of direct and cell-free enzymatic def
Early detection of pancreatic ductal adenocarcinoma by single-molecule profiling of pancreatic enzyme activities biorxiv.org 2026-06-09 Pancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer-related mortality, largely due to diagnosis at advanced stages.
Revealing the spatiotemporal dynamics of methionine metabolism with a genetically encoded single-fluorophore biosensor biorxiv.org 2026-06-09 Methionine is an essential amino acid, used for protein synthesis, redox homeostasis, and methylation reactions throughout the cell.
The KN domain of KANK proteins contains separable talin-binding and intramolecular interaction modules biorxiv.org 2026-06-09 KANK proteins link integrin adhesions to the cortical microtubule stabilising complex (CMSC) through interactions with the adhesion adaptor talin.
Differentiating 5-thiooxazoles from oxazolone-coupled thioamides in RiPP natural products biorxiv.org 2026-06-09 Conversion of cysteine residues to 5-thiooxazole moieties by multinuclear nonheme iron-dependent oxidative enzymes (MNIOs) is a prevalent modification
Porphyrin driven redox tuning in structurally defined de novo heme proteins biorxiv.org 2026-06-09 Designing redox proteins with predictable and tuneable electron transfer properties is a major goal in de novo bioenergetics.
Mapping metabolic phases through online pressure and backscatter rates biorxiv.org 2026-06-09 Microbial metabolism can be represented as an energy-conserving process (catabolism) and a biomass-forming reaction (anabolism).
Redox-regulated cysteine acylation governs β-lactam sensing by the Vibrio histidine kinase VbrK biorxiv.org 2026-06-09 The ability of pathogens to develop resistance mechanisms makes the continuous search for novel therapeutic targets indispensable.
Yersinia pestis lipoprotein SlyB promotes plague pathogenesis via envelope stress tolerance biorxiv.org 2026-06-09 Yersinia pestis, the etiological agent of plague, persists in an enzootic cycle involving mammals and fleas, requiring constant outer membrane (OM) ad
Functional divergence of the NSs protein defines interferon antagonism and viral fitness across Bhanja virus lineages. biorxiv.org 2026-06-09 Bhanja virus (BHAV) is a tick-borne bandavirus (Family Phenuiviridae) with a broad geographic distribution and documented neuroinvasive capacity, yet
TileBac: A Benchmark CryoEM Dataset of Bacteria in Ultralow-Dose Montage Tiles biorxiv.org 2026-06-09 Current segmentation models are capable of routine identification of biological features in noisy cryogenic electron microscopy (cryoEM) images.
Measure Catabolism: Real-time shifts in microbial metabolism through online pressure measurements biorxiv.org 2026-06-09 Microbial activity is often inferred from cell density measurements; however, biomass formation is merely an indirect, cumulative result of metabolism
TDP-43 self-assembly is regulated by its disordered NLS-region biorxiv.org 2026-06-09 Cytosolic inclusions of the RNA-binding protein TDP-43 are a pathological hallmark of several neurodegenerative diseases, such as amyotrophic lateral
Intensity-dependent topographical expansion of sensory representations biorxiv.org 2026-06-09 Neuroimaging studies typically assume that sensory properties are encoded in response magnitude within fixed neural populations.
Activity-Dependent Postsynaptic Mitochondrial ROS Signaling Drives Avoidance Plasticity in C. elegans biorxiv.org 2026-06-09 Reactive oxygen species (ROS) are signaling molecules involved in neuronal excitatory function, with mitochondrial ROS (mitoROS) playing key roles in
Human ASPDH is a 2-aminomuconate reductase that produces L-2-aminohex-3-enedioic acid in tryptophan catabolism biorxiv.org 2026-06-09 Most tryptophan catabolism in animals occurs through the kynurenine pathway, which generates the essential NAD cofactor and multiple bioactive metabol
D-Retro-Inverso Peptide Candidates for Inhibiting SAA Cardiac Amyloidosis biorxiv.org 2026-06-09 n a recent study of a mice model it was suggested that after myocardial infarction Serum Amyloid A (SAA) aggregates are formed that contribute to the
ECMME: an atlas of selection pressures on the mammalian extracellular matrix reveals contrasting evolutionary dynamics biorxiv.org 2026-06-10 The extracellular matrix (ECM) is a fundamental metazoan innovation that provides structural support and regulatory cues essential for multicellular l
Functional Continuum of GABAergic Synaptic Dynamics Reflects Genetic Identities biorxiv.org 2026-06-10 The language of the brain is articulated by temporal patterns of neuronal activity, which individual synapses interpret through distinct forms of syna
Crossmodal plasticity effects of hearing loss and ageing in the human auditory cortex biorxiv.org 2026-06-10 Crossmodal plasticity refers to the phenomenon by which typical sensory areas respond to stimulation in other sensory modalities when their main input
Individualised mapping of living human brain mitochondria by MRI reveals signatures of bioenergetic defects. biorxiv.org 2026-06-10 Mitochondria support the bioenergetic processes that enable brain function and cognition, but we have lacked a label-free, non-invasive approach to ex
Pathological variants in HPDL cause collapse of the neuro-glial unit during human cortical maturation biorxiv.org 2026-06-10 Biallelic variants in HPDL cause a severe neurological disorder in childhood, but the mechanisms linking early developmental abnormalities to later co
Longitudinal consensus clustering reveals the functional architecture of the developing rat brain biorxiv.org 2026-06-10 Resting-state fMRI-based mapping of functional networks in developing human populations holds promise for enhancing the diagnosis and treatment of psy
Structured and flexible representations in medial-frontal cortex support goal-directed navigation biorxiv.org 2026-06-10 Humans and animals plan actions to achieve goals in worlds that are complex and continually changing.
A non-canonical pallidothalamic pathway for motor control biorxiv.org 2026-06-10 Coordinated movement relies on interactions between the basal ganglia and the thalamus, yet the circuits linking these structures are not fully unders
An Effective Metal Nanoparticle-Based Drug Delivery System for an In Vitro Model of Non Small Cell Lung Cancer biorxiv.org 2026-06-09 This study presents the development and spectroscopic characterization of an erlotinib functionalized gold nanoparticle (erlotinib:AuNP) nanosystem de
Spatially-resolved integration of microglia morphological diversity and gene expression using Visium with protein co-detection biorxiv.org 2026-06-09 Microglia exhibit a dynamic range of morphologies that actively shift in response to local environmental cues.
HSSM: A Widely Applicable Toolbox for Hierarchical Bayesian Neuro-cognitive Modeling biorxiv.org 2026-06-09 Computational models are central to cognitive neuroscience, but their rigorous application to experimental datasets is often constrained to a narrow s
Learning induces activation-mechanism--dependent neural plasticity in an intracortical microstimulation task biorxiv.org 2026-06-09 Electrical microstimulation provides high-resolution control of neural circuits for causal studies and restoration of impaired functions, yet how resp