Utilizing a cell culture based novel cellular thermal shift assay to understand the isoform-dependent thermal stability of ApoE variants biorxiv.org 2026-06-11 Apolipoprotein E (ApoE) is the primary genetic risk modifier of late-onset Alzheimer's disease, with the E4 allele increasing risk up to 15-fold relat
Near-infra red light and mitochondrial large-conductance calcium-activated potassium channels: protection of hippocampal neurons, influence on channel activity and transcriptome remodelling biorxiv.org 2026-06-11 Photobiomodulation (PBM) is a therapeutic approach based on illumination with red or near-infrared (NIR) light.
Socially-mediated compensatory growth carries hidden sperm costs in male guppies biorxiv.org 2026-06-11 Phenotypic plasticity allows organisms to mitigate early-life adversity through compensatory growth, yet the long-term costs of such "catch-up" trajec
Female acoustic signaling of sexual immaturity depresses male courtship in Drosophila biorxiv.org 2026-06-11 In an early phase of life, most animals are behaviorally and physiologically not yet able to reproduce but show adaptations specific to a juvenile sta
DeePEn - A Depth sensitive benchmark for Protein Engineering biorxiv.org 2026-06-11 Recent progress in modeling techniques and high-throughput screening has significantly enhanced the accessibility of protein engineering.
Attenuation of value-to-evidence translation drives biased decision making in anxiety and depression biorxiv.org 2026-06-11 Anxiety and depression are globally prevalent conditions associated with maladaptive decision making.
Age-dependent Effects of Titrating Anodal Transcranial Direct Current Stimulation (tDCS) Intensity on Motor Sequence Learning biorxiv.org 2026-06-11 Optimising the currently heterogenous efficacy of transcranial direct current stimulation (tDCS) interventions for motor learning requires identifying
Pseudogenes confirm ongoing loss of ethylene biosynthesis in seagrasses biorxiv.org 2026-06-11 Many flowering plant species have adopted an aquatic lifestyle, contrasting with their terrestrial ancestors.
Explainable AI identifies H3K18ac as a new marker of active enhancers biorxiv.org 2026-06-11 Enhancers are non-coding regions of DNA that regulate gene transcription, yet the mechanisms underlying enhancer activity remain incompletely understo
Dairy wastewater grease stabilizes in situ mesophilic biomethanation for H2-to-CH4 conversion biorxiv.org 2026-06-11 Power-to-Gas technologies are emerging as a key strategy to integrate surplus renewable electricity into energy systems, through the conversion of gre
Tumour evolution as ground truth for cancer whole-genome sequencing biorxiv.org 2026-06-11 Cancer genomes are shaped by evolutionary processes that couple mutagenesis, clonal selection, chromosomal instability, spatial growth and treatment r
A Deep Hypergraph Learning Model for Predicting Antimicrobial Combination Effects Across Bacterial Targets biorxiv.org 2026-06-11 Antimicrobial resistance (AMR) creates an urgent need for efficient strategies to identify effective antibacterial combinations.
Amylo-Pipe: an integrated web server for mechanistic and kinetic prediction of protein and peptide aggregation biorxiv.org 2026-06-11 Protein aggregation is central to amyloid-related disorders and remains a major developability challenge for protein therapeutics.
A quantitative coordinate system for developmental dynamics biorxiv.org 2026-06-11 Quantitative comparison of morphogenesis across individuals remains a fundamental challenge, as developing embryos vary in shape, orientation and deve
PhyloZoo: a unified framework for phylogenetic network analysis in Python biorxiv.org 2026-06-11 Reticulate evolutionary processes (events in which lineages merge, such as hybridization, recombination, and horizontal gene transfer) are widespread
MARINER: a surround visual stimulator for vision research in aquatic animals biorxiv.org 2026-06-11 Aquatic vertebrates are increasingly used in neuroscience research, yet underwater visual stimulation remains a challenge.
Conserved Cell Type Signatures Across the Brainstem and Spinal Cord in the Mouse Central Nervous System biorxiv.org 2026-06-11 Understanding how cell types are organized across the central nervous system (CNS) is key to uncovering neural function.
Cerebrovascular pulsatility differs across vascular compartments and is altered by hypercapnic stimuli: a BOLD fMRI study biorxiv.org 2026-06-11 Cerebral small vessel disease and neurodegenerative disorders have been associated with increased cerebrovascular pulsatility.
Starvation modulates associative short-term memory of Drosophila in a task-dependent manner biorxiv.org 2026-06-11 It is widely believed that starvation favours the processing of food-related cues, a notion here called the 'adaptive specificity hypothesis'.
Mutant SOD1 expressed by oligodendrocytes aggregates in myelinic nanochannels and accelerates disease progression in familial ALS mice biorxiv.org 2026-06-11 Amyotrophic lateral sclerosis (ALS) is a highly debilitating and fatal disease characterized by the progressive loss of motor neurons.
A systematic imputation framework for sparse, multimodal space biology datasets: application to retinal imaging and omics from the RR9 mission biorxiv.org 2026-06-11 Space biology experiments are expensive, logistically complex, and inherently limited in sample size, resulting in datasets that are frequently incomp
DyMoTree decodes early cell state transitions and drivers from single-cell transcriptomes using a tree-structured neural network biorxiv.org 2026-06-11 Inferring early cell fate from single-cell RNA-sequencing data is essential for identifying cellular origins and fate plasticity in development and di
DModE: An end-to-end framework for Differential Modification and Expression Analysis of Nanopore direct RNA sequencing data biorxiv.org 2026-06-11 Summary: Nanopore direct RNA sequencing (DRS) enables simultaneous quantification of transcript abundance and RNA modifications from native RNA molecu
OMIO: A policy-driven Python library for reproducible microscopy image I/O biorxiv.org 2026-06-11 Modern fluorescence and multiphoton microscopy workflows operate within a heterogeneous ecosystem of file formats, partially overlapping metadata stan
Ultralow frequency vaso-oscillations in human cerebral arteries are independent from Mayer waves biorxiv.org 2026-06-11 This study tests the hypothesis that vasomotion, an ~ 0.1 Hz oscillation in arteriole diameter, is generated by intrinsic oscillations within the arte
Addressing the Elephant in the Room: A Quantitative Approach to Understanding 'Wild' biorxiv.org 2026-06-11 When applied to non-human animals,'wild' is a poorly defined concept despite its central role in conservation, wildlife management, and environmental
Reliability-weighted target-position estimation in a musculoskeletal arm model: adaptive priors and learned source weighting under violations of fixed-precision assumptions biorxiv.org 2026-06-11 Reliability-weighted integration is a normative account of cue combination, but its scope in musculoskeletal models and conditions requiring adaptive
A common connectome-based neural reference space across affective, autonomic, and wakefulness arousal biorxiv.org 2026-06-11 Arousal is often invoked to explain state-dependent variability in attention, emotion, memory, and decision-making.
Spatial Transcriptomics reveals a T cell-mediated microglial activation axis of neurodegeneration following immune checkpoint inhibition biorxiv.org 2026-06-11 Immune checkpoint inhibitor (ICI) combinations that block cytotoxic T lymphocyte associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD
Pathogen-driven reactivation of metabolite prodrugs defines nitroxoline's iron-deprivation antibiotic activity biorxiv.org 2026-06-11 The rise of antimicrobial resistance warrants renewed attention to established but overlooked antibiotics such as nitroxoline (NTX).