Self-supervised Internal Learning Enhances Isotropic Resolution for Three-dimensional Fluorescence Microscopy biorxiv.org 2026-06-08 Three dimensional fluorescence microscopy often exhibits anisotropic resolution because axial information is poorly sampled and more blurred than late
Geometric confinement regulates ERK signaling dynamics and collective migration biorxiv.org 2026-06-08 Collective cell migration is a fundamental process in morphogenesis, tissue repair, cancer invasion, and frequently occurs under geometric confinement
A Neuroimmune Feedforward Circuit Linking REM Sleep with Stress-Related Behavioral Susceptibility biorxiv.org 2026-06-08 Rapid eye movement (REM) sleep is strongly associated with stress susceptibility, yet the underlying neuroimmune mechanisms remain unclear, limiting t
ANNet: A first-principles neural network for forward and inverse dynamics biorxiv.org 2026-06-08 Biological and robotic systems must solve two related computations to move: inverse dynamics, which determines the forces or torques needed to produce
A streamlined spectral cytometry method for FAD and NADH autofluorescence analysis in immunometabolic studies biorxiv.org 2026-06-08 We present a streamlined protocol that enables the characterization of the metabolic state of immune cell populations through their distinct NADH/FAD
Novel mouse models for perianal fistulizing Crohns disease reveal therapeutic value of interferon-gamma antagonists biorxiv.org 2026-06-08 Background and Aims: Perianal fistulizing Crohn's disease (PFCD) is a challenging complication with poorly understood pathogenesis and limited treatme
Assembly principles of a SYCP2-HORMAD1-HORMAD2 mammalian meiotic axis complex biorxiv.org 2026-06-08 During meiotic prophase I, the chromosome axis orchestrates programmed DNA double-strand break formation, repair and synapsis between homologous chrom
Prey diversity revealed by environmental DNA elucidates ecological specialisation and social structure in bottlenose dolphins biorxiv.org 2026-06-08 Human disturbance drives rapid biodiversity loss, yet how prey diversity shapes individual niche differentiation and scales up to structure social org
Malaise trap samples of 1000 individuals per week suggest 4 million insects per hectare in the boreal zone biorxiv.org 2026-06-08 A basic question in ecological research and biodiversity monitoring concerns the estimation of species abundances from trap catches.
Charting the insect biodiversity of Crete: insights from a pilot metabarcoding survey biorxiv.org 2026-06-08 Among eukaryotes, insects are by far the most diverse organisms on Earth, yet their global decline threatens ecosystem stability.
Mean yield gap explains differences in yield stability between organic and conventional systems biorxiv.org 2026-06-08 Over recent decades, numerous studies have compared agricultural productivity across different management systems and environments, with increasing at
Thiamine availability and acquisition differ between natural and controlled environments biorxiv.org 2026-06-08 Thiamine Deficiency Complex (TDC) is a reproductive disorder that affects recruitment of diverse salmonine populations globally.
Reconciling fast Hepatitis B evolutionary rates with ancient co-divergence biorxiv.org 2026-06-08 Estimating evolutionary rates and divergence times for hepatitis B virus (HBV) has long been complicated by conflicting calibration approaches and ext
Shear-Induced Oscillations and Hydrodynamic Buffering Stabilize Sperm Surface Navigation biorxiv.org 2026-06-08 Navigation near boundaries under strong flow is central to microswimmer transport in active matter.
Comprehensive evaluation of LLM capabilities for interpretation and analysis of genome-scale metabolic models in metabolic engineering biorxiv.org 2026-06-08 Genome-scale metabolic models (GSMs) underpin pathway and strain engineering by linking genes to metabolic reactions and enabling system-level simulat
Diversity of Mammal Fauna in a Remnant of the Atlantic Forest in the Middle of a Megalopolis biorxiv.org 2026-06-08 A remnant Atlantic Forest fragment within Sao Paulo's urban environment supports six mammal species, with Didelphis being most abundant, while maintai
Oscillatory correlates of visuomotor control under varying amount of feedback delay biorxiv.org 2026-06-08 A weighted integration of visual and proprioceptive movement feedback is key for an adaptive body representation by the brain.
Motor Resonance of Musical Emotion: A Machine Learning Approach to EEG Decoding During Expressive Music Performance biorxiv.org 2026-06-08 Understanding the neural dynamics underlying expressive musical performance remains a major challenge at the intersection of neuroscience, music cogni
Emotion Representation and Neural Synchrony: Decoding Valence and Arousal with Wearable EEG biorxiv.org 2026-06-08 Emotions are dynamic experiences that unfold over time, yet most affective neuroscience studies have relied on static stimuli and laboratory-based EEG
Immune repertoire profiling reveals extensive clonal expansion of T and B cells in CXCL9-rich niches in sinonasal cancer biorxiv.org 2026-06-08 Sinonasal cancer (SNC) is a rare and aggressive head and neck cancer with limited therapeutic options and an incompletely defined immune microenvironm
Development of circadian immune regulation in early life biorxiv.org 2026-06-08 Circadian rhythms temporally regulate immune cell trafficking, abundance, and immune responsiveness in adults, yet how this rhythmic organization emer
Scene Structure Predicts Perceptual Decisions in Naturalistic Detection Tasks biorxiv.org 2026-06-08 The human visual system can identify objects in complex natural scenes, yet the mechanisms supporting robust perception under such variable conditions
Eosinophil-epithelial interactions mediate protective intestinal remodeling during food allergy biorxiv.org 2026-06-08 Food allergies are associated with progressive gastrointestinal symptoms driven by exacerbated mucosal type-2 immunity.
Statistical Methodology for Qualification of a Non-Clinical Risk Assessment Peptide:T Cell Proliferation Assay to Support Decision Making biorxiv.org 2026-06-08 Antibody- and cell-mediated immune responses against biologics, should they occur, can impact treatment efficacy and potentially pose severe risks to
Humanized FLT3 mice display enhanced tissue engraftment and support HIV-1 persistence and rebound biorxiv.org 2026-06-08 Despite advances in antiretroviral therapy (ART), HIV-1 cure efforts remain hindered by viral reservoirs in long-lived myeloid cells and immune-privil
Airspace miR-146a levels in ventilated patients decrease with age and correlate with mortality biorxiv.org 2026-06-08 The acute respiratory distress syndrome is a heterogenous syndrome characterized by the rapid development of respiratory failure.
Transcriptionally Active HIV Reservoirs Enriched for Interferon-Inducible APOBEC3-Related Mutational Signatures Associate with Arterial Inflammation biorxiv.org 2026-06-08 Despite suppressive antiretroviral therapy (ART), people with HIV (PWH) remain at increased risk of cardiovascular disease (CVD), likely driven, at le
ACC1-Dependent De Novo Lipogenesis Sustains Hematopoietic Stem Cell Quiescence and Self-Renewal biorxiv.org 2026-06-08 Certain aspects of lipid metabolism are known to regulate hematopoietic stem cell (HSC) function, including fatty acid oxidation and lipid uptake, but
The molecular determinants of PABPC-mediated deadenylation rate biorxiv.org 2026-06-08 Deadenylation, the enzymatic shortening of the poly(A) tail, is typically the first committed step of mRNA decay.
A ubiquitin chain-feeding mechanism for BRCA1-A biorxiv.org 2026-06-08 The BRCA1-A complex is a multi-subunit, metallo-deubiquitinating enzyme (metallo-DUB) involved in genome maintenance.